公开(公告)号：US07709510B2

公开(公告)日：2010-05-04

申请号：US10468379

申请日：2002-02-19

申请人： Thomas Arrhenius ,  Jie Fei Cheng ,  Mark E. Wilson ,  Rossy Serafimov ,  Alex M. Nadzan ,  Gary D. Lopaschuk ,  Jason R. Dyck

发明人： Thomas Arrhenius ,  Jie Fei Cheng ,  Mark E. Wilson ,  Rossy Serafimov ,  Alex M. Nadzan ,  Gary D. Lopaschuk ,  Jason R. Dyck

IPC分类号： A61K31/425 ,  C07D277/00 ,  C07D277/62

CPC分类号： C07D277/70 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/538 ,  A61K31/548 ,  A61K31/55 ,  C07D417/04 ,  C07D513/04

摘要： The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.

摘要翻译： 本发明涉及治疗某些代谢疾病的方法，以及新化合物及其前药，和/或药学上可接受的盐，含有用于治疗这些疾病的化合物的药物组合物。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶（MCD）来治疗心血管疾病，糖尿病，癌症，酸中毒和肥胖症的新型化合物和组合物的用途。 这些化合物具有式（I）和（II），其中Y，C，R 1，R 2，R 6和R 7在本文中定义。

公开(公告)号：US07449482B2

公开(公告)日：2008-11-11

申请号：US10900705

申请日：2004-07-28

申请人： Jie Fei Cheng ,  Mi Chen ,  Thomas Arrhenius ,  Mark E. Wilson ,  Gary D. Lopaschuk ,  Jason R. Dyck ,  Rossy Serafimov

发明人： Jie Fei Cheng ,  Mi Chen ,  Thomas Arrhenius ,  Mark E. Wilson ,  Gary D. Lopaschuk ,  Jason R. Dyck ,  Rossy Serafimov

IPC分类号： A61K31/4468

CPC分类号： C07D417/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/55

摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。

公开(公告)号：US20080161358A1

公开(公告)日：2008-07-03

申请号：US11866266

申请日：2007-10-02

申请人： Mark D. Kafka ,  Mark E. Wilson ,  Anna Russell ,  Gary D. Lopaschuk ,  Jason R. Dyck

发明人： Mark D. Kafka ,  Mark E. Wilson ,  Anna Russell ,  Gary D. Lopaschuk ,  Jason R. Dyck

IPC分类号： A61K31/428 ,  C07D277/72 ,  C07D417/02 ,  A61P9/00 ,  A61P3/04 ,  A61P35/00 ,  A61P3/10 ,  A61P3/00 ,  A61K31/4439

CPC分类号： C07D277/70 ,  C07D417/12

摘要： The present invention provides previous methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。

公开(公告)号：US07285562B2

公开(公告)日：2007-10-23

申请号：US10900957

申请日：2004-07-28

申请人： Mark D. Kafka ,  Mark E. Wilson ,  Anna Russell ,  Gary D. Lopaschuk ,  Jason R. Dyck

发明人： Mark D. Kafka ,  Mark E. Wilson ,  Anna Russell ,  Gary D. Lopaschuk ,  Jason R. Dyck

IPC分类号： A61K31/44 ,  A61K31/425 ,  A61K31/415

CPC分类号： C07D277/70 ,  C07D417/12

摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity

摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出

公开(公告)号：US4598981A

公开(公告)日：1986-07-08

申请号：US698641

申请日：1985-02-05

申请人： Kenneth L. Hallam ,  Barton J. Howell ,  Mark E. Wilson

发明人： Kenneth L. Hallam ,  Barton J. Howell ,  Mark E. Wilson

IPC分类号： G02B17/06 ,  G03B11/04

CPC分类号： G02B17/0636

摘要： An unobscured three mirror wide-angle telescopic imaging system comprised of an input baffle which provides a 20.degree. (Y axis).times.30.degree. (X axis) field of view, a primary mirror having a convex spherical surface, a secondary mirror having a concave ellipsoidal reflecting surface, a tertiary mirror having a concave spherical reflecting surface. The mirrors comprise mirror elements which are offset segments of parent mirrors whose axes and vertices commonly lie on the system's optical axis. An iris diaphragm forming an aperture stop is located between the secondary and tertiary mirror with its center also being coincident with the optical axis and being further located at the beam waist of input light beams reflected from the primary and secondary mirror surfaces. At the system focus following the tertiary mirror is located a flat detector which may be, for example, a TV imaging tube or a photographic film. When desirable, a spectral transmission filter is placed in front of the detector in close proximity thereto.

摘要翻译： 一种视野开阔的三镜广角伸缩成像系统，包括提供20°（Y轴）×30°（X轴）视场的输入挡板，具有凸球面的主镜，具有凹椭球的副镜 反射面，具有凹球面反射面的第三反射镜。 镜子包括镜子元件，镜子元件是父镜子的偏移片段，其轴和顶点通常位于系统的光轴上。 形成孔径光阑的虹膜光阑位于第二和第三反射镜之间，其中心也与光轴重合，并且还位于从主镜面和次镜面反射的输入光束的束腰处。 在第三反射镜之后的系统焦点位于平面检测器，其可以是例如TV成像管或照相胶片。 当期望时，光谱透射滤光器放置在紧邻其的检测器的前面。

公开(公告)号：US20090124660A1

公开(公告)日：2009-05-14

申请号：US12245558

申请日：2008-10-03

申请人： Jie Fei Cheng ,  Mi Chen ,  Thomas Arrhenius ,  Mark E. Wilson ,  Gary D. Lopaschuk ,  Jason R. Dyck ,  Rossy Serafimov

发明人： Jie Fei Cheng ,  Mi Chen ,  Thomas Arrhenius ,  Mark E. Wilson ,  Gary D. Lopaschuk ,  Jason R. Dyck ,  Rossy Serafimov

IPC分类号： A61K31/454 ,  C07D417/12

CPC分类号： C07D417/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/55

摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。

公开(公告)号：US06849394B2

公开(公告)日：2005-02-01

申请号：US10081097

申请日：2002-02-21

申请人： Kevin J. Rozeboom ,  Mark E. Wilson

发明人： Kevin J. Rozeboom ,  Mark E. Wilson

IPC分类号： A01N1/02 ,  A61K35/52 ,  C12N5/02 ,  C12N5/076 ,  A01N1/00 ,  C12N5/06 ,  C12N5/08

CPC分类号： A61K35/52 ,  A01N1/021 ,  A01N1/0226 ,  C12N5/061

摘要： Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian, avian, or piscian reproductive sperm cells. The compositions comprise a suitable reproductive cell media and a transforming growth factor, an insulin-like growth factor, or zinc, and, optionally, inositol, transferrin, or fructose, or combinations thereof.

摘要翻译： 公开了用于哺乳动物，禽或生殖精子细胞的收集，保持，加工，体外受精，性别培养或储存（包括长期冷冻保存）的哺乳动物，禽类或者piscian生殖细胞的组合物。 组合物包含合适的生殖细胞培养基和转化生长因子，胰岛素样生长因子或锌，以及任选的肌醇，转铁蛋白或果糖或其组合。

公开(公告)号：US06557255B2

公开(公告)日：2003-05-06

申请号：US09851735

申请日：2001-05-09

申请人： Bryan A. Billmyer ,  Mark E. Wilson

发明人： Bryan A. Billmyer ,  Mark E. Wilson

IPC分类号： B23P1100

CPC分类号： F16L41/001 ,  Y10T29/49353 ,  Y10T29/49778 ,  Y10T29/4978

摘要： A panel assembly for transferring fluids from one location to another comprises a panel structure with openings, a nozzle projecting through each opening and a sleeve affixed between the nozzle and its respective opening. Each nozzle includes a tubular portion with a connection end adapted for connection to a transfer conduit. The connection ends of the nozzles are preferably aligned with a common reference plane. Each sleeve has an outer surface with a length that is greater than a combination of a thickness of the panel and any deformity on the panel. With this arrangement, alignment of the connection ends with the common reference plane is independent of any deformity on the panel. A method of constructing a panel assembly includes determining if any defects are present on the inner surface of the tubular portion before installing the nozzle on the panel, and precluding potential inner surface defects during installation of the nozzle on the panel.

摘要翻译： 用于将流体从一个位置传递到另一个位置的面板组件包括具有开口的面板结构，通过每个开口突出的喷嘴以及固定在喷嘴与其相应开口之间的套筒。 每个喷嘴包括管状部分，其具有适于连接到输送导管的连接端。 喷嘴的连接端优选地与公共参考平面对准。 每个套筒具有外表面，其长度大于面板的厚度和面板上的任何变形的组合。 通过这种布置，连接端与公共参考平面的对准与面板上的任何变形无关。 构造面板组件的方法包括在将喷嘴安装在面板上之前确定在管状部分的内表面上是否存在任何缺陷，并且在将喷嘴安装在面板上时排除潜在的内表面缺陷。

公开(公告)号：US06254143B1

公开(公告)日：2001-07-03

申请号：US09295956

申请日：1999-04-21

申请人： Bryan A. Billmyer ,  Mark E. Wilson

发明人： Bryan A. Billmyer ,  Mark E. Wilson

IPC分类号： F16L4300

CPC分类号： F16L41/001 ,  Y10T29/49353 ,  Y10T29/49778 ,  Y10T29/4978

摘要： A panel assembly for transferring fluids from one location to another comprises a panel structure with openings, a nozzle projecting through each opening and a sleeve affixed between the nozzle and its respective opening. Each nozzle includes a tubular portion with a connection end adapted for connection to a transfer conduit. The connection ends of the nozzles are preferably aligned with a common reference plane. Each sleeve has an outer surface with a length that is greater than a combination of a thickness of the panel and any deformity on the panel. With this arrangement, alignment of the connection ends with the common reference plane is independent of any deformity on the panel. A method of constructing a panel assembly includes determining if any defects are present on the inner surface of the tubular portion before installing the nozzle on the panel, and precluding potential inner surface defects during installation of the nozzle on the panel.

摘要翻译： 用于将流体从一个位置传递到另一个位置的面板组件包括具有开口的面板结构，通过每个开口突出的喷嘴以及固定在喷嘴与其相应开口之间的套筒。 每个喷嘴包括管状部分，其具有适于连接到输送导管的连接端。 喷嘴的连接端优选地与公共参考平面对准。 每个套筒具有外表面，其长度大于面板的厚度和面板上的任何变形的组合。 通过这种布置，连接端与公共参考平面的对准与面板上的任何变形无关。 构造面板组件的方法包括在将喷嘴安装在面板上之前确定在管状部分的内表面上是否存在任何缺陷，并且在将喷嘴安装在面板上时排除潜在的内表面缺陷。

公开(公告)号：US4510725A

公开(公告)日：1985-04-16

申请号：US303179

申请日：1981-09-17

申请人： Mark E. Wilson

发明人： Mark E. Wilson

IPC分类号： E04B2/02 ,  E04C1/40 ,  E04C1/10

CPC分类号： E04C1/40 ,  E04B2002/0208 ,  E04B2002/0226 ,  Y10T428/24149

摘要： A rectangular building block is formed from a composition of wood fiber and a thermoplastic or thermosetting resin. The block comprises an outer shell and a web defining a plurality of hexagonal cross-sectional openings forming a honeycomb cell within the shell. The blocks may be interlocked and arranged to form a structure.

摘要翻译： 矩形构件由木纤维和热塑性或热固性树脂的组合物形成。 该块包括外壳和限定多个六边形横截面开口的腹板，所述多个六边形横截面开口在壳体内形成蜂窝单元。 块可以互锁并布置成形成结构。