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公开(公告)号：US06497157B1
公开(公告)日：2002-12-24
申请号：US09711287
申请日：2000-11-13
申请人： Tacey X. Viegas , Gerald Brinker , Michael Cai
发明人： Tacey X. Viegas , Gerald Brinker , Michael Cai
IPC分类号： G01N3315
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006
摘要： For intrinsic dissolution testing, a drug pellet (i.e., the dissolution test sample) is retained within a cylindrical recess in a sample holder that is placed at the bottom of a dissolution vessel containing an appropriate dissolution medium with the sample holder oriented with the drug pellet facing up. During the testing cycle, the dissolution medium may be stirred, e.g., using a conventional USP 2 rotating paddle, while the sample holder (and drug pellet) remain stationary at the bottom of the vessel. The orientation of the drug pellet during testing (i.e., facing up) decreases the likelihood of retention of air bubbles formed at the surface of the drug pellet (which bubbles could otherwise decrease the effective dissolution rate), thereby providing more accurate and consistent intrinsic dissolution test results.
摘要翻译： 对于固有溶解试验，将药物丸粒（即溶出试验样品）保留在样品保持器的圆柱形凹部内，该样品保持器放置在含有适当溶解介质的溶解容器的底部，样品保持器与药物颗粒 朝上。 在测试循环期间，可以例如使用常规的USP 2旋转桨来搅拌溶解介质，同时样品保持器（和药物颗粒）在容器的底部保持静止。 在测试期间药物颗粒的取向（即面朝上）降低了在药物颗粒表面形成的气泡的保留的可能性（该气泡否则可能降低有效溶解速率），从而提供更准确和一致的内在溶解 检测结果。
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公开(公告)号：US5958443A
公开(公告)日：1999-09-28
申请号：US773755
申请日：1996-12-23
IPC分类号： A61F9/008 , A61K9/00 , A61L15/22 , A61L15/44 , A61L24/00 , A61L24/04 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/16 , A61K31/77 , A61K31/725 , A61K31/73 , A61K2/14
CPC分类号： A61L31/16 , A61F9/00819 , A61K9/0048 , A61L15/225 , A61L15/44 , A61L24/0015 , A61L24/0031 , A61L24/043 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/041 , A61F2009/00872 , A61L2300/00 , A61L2430/16 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S623/905
摘要： Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
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公开(公告)号：US5318780A
公开(公告)日：1994-06-07
申请号：US785305
申请日：1991-10-30
IPC分类号： A61F9/008 , A61K9/00 , A61L15/22 , A61L15/44 , A61L24/00 , A61L24/04 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/16 , A61K31/77 , A61K31/725 , A61K31/73 , C08L5/04
CPC分类号： A61L31/16 , A61F9/00819 , A61K9/0048 , A61L15/225 , A61L15/44 , A61L24/0015 , A61L24/0031 , A61L24/043 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/041 , A61F2009/00872 , A61L2300/00 , A61L2430/16 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S623/905
摘要： Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
摘要翻译： 平衡的pH，高渗，低渗或凝血凝胶是药物递送的理想载体。 它们特别适用于局部体腔或药物或诊断剂的注射应用; 药物或诊断剂递送到哺乳动物的眼睛; 作为保护性角膜盾; 或作为可用于激光重塑角膜的可消融角膜掩模。 没有添加药物或诊断剂的组合物可用作医疗装置，例如在手术或其他损伤的组织分离中作为防止粘连的手段。
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34.发明授权Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers 失效具有含有聚氧化烯共聚物的热可逆凝胶的体腔药物递送
公开(公告)号：US5292516A
公开(公告)日：1994-03-08
申请号：US790664
申请日：1991-11-08
CPC分类号： A61K47/10 , A61K47/18 , A61K9/0014 , Y10S514/944
摘要： Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.
摘要翻译： 等渗，等渗，pH平衡的热可逆性凝胶是药物输送到哺乳动物体腔的理想载体。 可以通过假设存在于所述凝胶中的聚氧化烯嵌段共聚物或聚醚在凝胶状态下不影响重量摩尔渗透压浓度来计算凝胶状态下的重量摩尔渗透压浓度，尽管它确实有助于液态渗透压。
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35.发明授权Ablatable mask of polyoxyalkylene polymer and ionic polysaccharide gel for laser reprofiling of the cornea 失效聚氧乙烯聚合物和离子多糖凝胶的可再生面膜用于角膜激光重塑
公开(公告)号：US5277911A
公开(公告)日：1994-01-11
申请号：US604705
申请日：1990-10-26
IPC分类号： A61F9/008 , A61K9/00 , A61K47/10 , A61K47/18 , A61K47/36 , A61F9/04 , A61B6/10 , A61K9/10 , A61K47/38 , A61K47/44
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/18 , A61K47/36 , A61F9/00819 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S525/916
摘要： Balanced pH, thermo-irreversible polyoxyalkylene polymer and ionic polysaccharide gels are ideal materials for use as an ablatable mask or coating over the cornea of the eye of a mammal during excimer laser keratectomy. The depth and smoothness of the ablated corneal surface can be controlled by molding the desired surface curvature into the mask surface using a contact lens as a mold which is pressed onto the gel surface coating the cornea.
摘要翻译： 平衡的pH，热不可逆的聚氧化烯聚合物和离子多糖凝胶是在准分子激光角膜切除术期间用作哺乳动物眼睛角膜上的可消融面罩或涂层的理想材料。 烧蚀的角膜表面的深度和平滑度可以通过使用隐形眼镜作为模具将所需的表面曲率模制到掩模表面中来控制，该模具被压在涂覆角膜的凝胶表面上。
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公开(公告)号：US5124151A
公开(公告)日：1992-06-23
申请号：US563764
申请日：1990-08-07
CPC分类号： A61K9/0019 , A61K47/10 , A61K47/18 , A61K47/36
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug injection into the body of a mammal.
摘要翻译： 平衡的pH，热不可逆凝胶是药物注入哺乳动物身体的理想载体。
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公开(公告)号：US5071644A
公开(公告)日：1991-12-10
申请号：US563639
申请日：1990-08-07
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/18 , A61K47/36 , A61K9/0014 , Y10S514/944
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to the skin of a mammal.
摘要翻译： 平衡的pH，热不可逆凝胶是药物递送到哺乳动物皮肤的理想载体。
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