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1.发明授权Topical drug delivery with polyoxyalkylene polymer thermoreversible gels adjustable for pH and osmolality 失效用聚氧亚烷基聚合物热可逆凝胶的局部药物递送可调节pH和重量摩尔渗透压浓度
公开(公告)号：US5298260A
公开(公告)日：1994-03-29
申请号：US895949
申请日：1992-06-09
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/18 , Y10S514/944
摘要： Iso-osmotic, hyperosmotic, or hypo-osmotic, pH balanced, thermoreversible gels are ideal medical devices or vehicles for drug delivery to the skin of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the measured osmolality in the liquid state.
摘要翻译： 等渗，高渗或低渗，pH平衡的热可逆性凝胶是药物递送至哺乳动物皮肤的理想医疗装置或载体。 可以通过假定存在于所述凝胶中的聚氧化烯嵌段共聚物或聚醚对凝胶状态中的重量摩尔渗透压浓度没有贡献来计算凝胶状态下的重量摩尔渗透压浓度，尽管它确实有助于在液态中测量的重量摩尔渗透压浓度。
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2.发明授权Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH 失效使用热可逆性聚氧化烯凝胶进行眼科药物输送可调节pH值
公开(公告)号：US5300295A
公开(公告)日：1994-04-05
申请号：US759234
申请日：1991-09-13
CPC分类号： A61K47/10 , A61K47/18 , A61K9/0048 , A61K9/06 , Y10S514/912 , Y10S514/944
摘要： Aqueous gel drug delivery compositions and medical devices, useful for treating an eye condition, having hyperosmotic, iso-osmotic or hypo-osmotic characteristics in the gel state, are obtained by calculating the osmolality required in the liquid state to reach a desired osmotic force in the gelled state by assuming that a polyoxyalkylene block copolymer does not contribute to the osmolality in the gel state.
摘要翻译： 通过计算在液体状态下达到期望的渗透压所需的重量摩尔渗透压浓度，可以获得在凝胶状态下具有高渗透性，渗透性或低渗透性的治疗眼睛状况的水凝胶药物递送组合物和医疗装置 通过假定聚氧化烯嵌段共聚物在凝胶状态下不影响重量摩尔渗透压浓度，则凝胶化状态。
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3.发明授权Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers 失效通过注射含有聚氧化烯共聚物的热可逆凝胶进行药物递送
公开(公告)号：US5306501A
公开(公告)日：1994-04-26
申请号：US791119
申请日：1991-11-08
CPC分类号： A61K47/18 , A61K47/10 , A61K9/0019 , Y10S514/944
摘要： Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal medical devices or vehicles for drug injection into the body of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.
摘要翻译： 等渗，等渗，pH平衡的热可逆凝胶是用于药物注射到哺乳动物体内的理想医疗装置或载体。 可以通过假设存在于所述凝胶中的聚氧化烯嵌段共聚物或聚醚在凝胶状态下不影响重量摩尔渗透压浓度来计算凝胶状态下的重量摩尔渗透压浓度，尽管它确实有助于液态渗透压。
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4.发明授权Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers 失效具有含有聚氧化烯共聚物的热可逆凝胶的体腔药物递送
公开(公告)号：US5292516A
公开(公告)日：1994-03-08
申请号：US790664
申请日：1991-11-08
CPC分类号： A61K47/10 , A61K47/18 , A61K9/0014 , Y10S514/944
摘要： Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.
摘要翻译： 等渗，等渗，pH平衡的热可逆性凝胶是药物输送到哺乳动物体腔的理想载体。 可以通过假设存在于所述凝胶中的聚氧化烯嵌段共聚物或聚醚在凝胶状态下不影响重量摩尔渗透压浓度来计算凝胶状态下的重量摩尔渗透压浓度，尽管它确实有助于液态渗透压。
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公开(公告)号：US6136334A
公开(公告)日：2000-10-24
申请号：US330618
申请日：1999-06-11
IPC分类号： A61F9/008 , A61K9/00 , A61L15/22 , A61L15/44 , A61L24/00 , A61L24/04 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/16 , A61K31/74 , A61K9/50 , A61K31/765 , A61K31/785
CPC分类号： A61L31/16 , A61F9/00819 , A61K9/0048 , A61L15/225 , A61L15/44 , A61L24/0015 , A61L24/0031 , A61L24/043 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/041 , A61F2009/00872 , A61L2300/00 , A61L2430/16 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S623/905
摘要： Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
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公开(公告)号：US5376693A
公开(公告)日：1994-12-27
申请号：US604701
申请日：1990-10-26
IPC分类号： A61F9/008 , A61K9/00 , A61K47/10 , A61K47/18 , A61K47/36 , A61F2/14 , C08L5/04 , C08L71/02 , G02C7/04
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/18 , A61K47/36 , A61F9/00819 , Y10S514/944 , Y10S524/916 , Y10S525/937
摘要： Balanced pH, thermo-irreversible gels comprising a polyoxyalkylene compound and an ionic polysaccharide are ideal materials for the formation of a protective contact lens over the cornea of the eye of a mammal.
摘要翻译： 包含聚氧化烯化合物和离子多糖的平衡pH，热不可逆凝胶是在哺乳动物眼睛的角膜上形成保护性隐形眼镜的理想材料。
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7.发明授权公开(公告)号：US06346272B1
公开(公告)日：2002-02-12
申请号：US08908747
申请日：1997-08-07
IPC分类号： A61K910
CPC分类号： A61K9/0048 , A61K9/0014 , A61K47/10 , A61K47/18 , A61K47/36 , Y10S514/944 , Y10S514/966 , Y10S514/967
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.
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公开(公告)号：US5593683A
公开(公告)日：1997-01-14
申请号：US205305
申请日：1994-03-03
CPC分类号： A61K47/18 , A61K47/10 , A61K9/0014 , Y10S514/912 , Y10S514/944
摘要： Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal vehicles for drug or diagnostic agent delivery.
摘要翻译： 基于用于医疗应用的含水凝胶的组合物，包含聚氧化烯共聚物。 这种等渗，等渗，pH平衡，热可逆凝胶的凝胶是用于药物或诊断剂递送的理想载体。
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9.发明授权Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels 失效体腔药物递送与热不可逆的聚氧化烯和离子多糖凝胶
公开(公告)号：US5143731A
公开(公告)日：1992-09-01
申请号：US563640
申请日：1990-08-07
CPC分类号： A61K47/36 , A61K47/10 , A61K47/18 , A61K9/0014 , A61K9/0048 , Y10S424/14 , Y10S514/944 , Y10S514/966 , Y10S514/967
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.
摘要翻译： 平衡的pH，热不可逆凝胶是药物递送到哺乳动物体腔的理想载体。 凝胶含有聚氧化烯嵌段共聚物或聚醚与在抗衡离子存在下不可逆地凝胶化的离子多糖的混合物。
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公开(公告)号：US5847023A
公开(公告)日：1998-12-08
申请号：US552973
申请日：1995-11-03
CPC分类号： A61K47/10 , A61K47/18 , A61K47/36 , A61K9/0048 , Y10S524/916 , Y10S525/937
摘要： Balanced pH, thermo-irreversible gels comprising a polyoxyalkylene compound and an ionic polysaccharide are ideal materials for the formation of a protective contact lens over the cornea of the eye of a mammal.
摘要翻译： 包含聚氧化烯化合物和离子多糖的平衡pH，热不可逆凝胶是在哺乳动物眼睛的角膜上形成保护性隐形眼镜的理想材料。
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