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公开(公告)号：US20080161263A1
公开(公告)日：2008-07-03
申请号：US11981211
申请日：2007-10-30
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
IPC分类号： A61K31/7088 , C12N15/62 , A61P31/06 , C12N15/63
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20070141087A1
公开(公告)日：2007-06-21
申请号：US11505569
申请日：2006-08-16
申请人： Steven Reed , Yasir Skeiky , Davin Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas Vedvick , Daniel Twardzik , Michael Lodes , Ronald Hendrickson
发明人： Steven Reed , Yasir Skeiky , Davin Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas Vedvick , Daniel Twardzik , Michael Lodes , Ronald Hendrickson
CPC分类号： C12Q1/6883 , A61K39/00 , C07K14/35 , C07K16/1289 , C07K2319/00 , C12Q1/689 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。
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公开(公告)号：US20060171965A1
公开(公告)日：2006-08-03
申请号：US11396117
申请日：2006-03-30
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
IPC分类号： A61K39/04
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US20060034764A1
公开(公告)日：2006-02-16
申请号：US11201519
申请日：2005-08-10
申请人： Steven Reed , Yasir Skeiky , Davin Dillon , Mark Alderson , Antonio Campos-Neto
发明人： Steven Reed , Yasir Skeiky , Davin Dillon , Mark Alderson , Antonio Campos-Neto
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/55505 , C07K14/35 , C07K2319/00 , C07K2319/40 , C12N15/62
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
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公开(公告)号：US07935353B2
公开(公告)日：2011-05-03
申请号：US11476254
申请日：2006-06-27
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US07064195B2
公开(公告)日：2006-06-20
申请号：US10359459
申请日：2003-02-05
申请人： Yasir Skeiky , Mark Alderson , Antonio Campos-Neto
发明人： Yasir Skeiky , Mark Alderson , Antonio Campos-Neto
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
摘要翻译： 本发明涉及结核分枝杆菌抗原的融合蛋白。 特别涉及两种融合蛋白，其中每种融合蛋白含有三种单独的结核分枝杆菌抗原，以及两种结核分枝杆菌抗原的融合蛋白，其编码序列及其用于治疗和预防结核病的方法。
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公开(公告)号：US07009042B1
公开(公告)日：2006-03-07
申请号：US09684215
申请日：2000-10-06
申请人： Yasir Skeiky , Jeffrey Guderian
发明人： Yasir Skeiky , Jeffrey Guderian
CPC分类号： C07K14/35 , A61K38/00 , C07K2319/00
摘要： The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.
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公开(公告)号：US20130052229A1
公开(公告)日：2013-02-28
申请号：US13560514
申请日：2012-07-27
IPC分类号： A61K39/04 , A61P31/06 , C07K19/00 , C07H21/04 , A61K31/711
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US07927611B2
公开(公告)日：2011-04-19
申请号：US11929064
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US20080176798A1
公开(公告)日：2008-07-24
申请号：US11929064
申请日：2007-10-30
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , A61K31/7088 , C12N15/64 , C12N1/21 , C12P21/00 , A61P31/06
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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