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公开(公告)号：US07064195B2
公开(公告)日：2006-06-20
申请号：US10359459
申请日：2003-02-05
申请人： Yasir Skeiky , Mark Alderson , Antonio Campos-Neto
发明人： Yasir Skeiky , Mark Alderson , Antonio Campos-Neto
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
摘要翻译： 本发明涉及结核分枝杆菌抗原的融合蛋白。 特别涉及两种融合蛋白，其中每种融合蛋白含有三种单独的结核分枝杆菌抗原，以及两种结核分枝杆菌抗原的融合蛋白，其编码序列及其用于治疗和预防结核病的方法。
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公开(公告)号：US20060292169A1
公开(公告)日：2006-12-28
申请号：US11511587
申请日：2006-08-28
申请人： Steven Reed , Yasir Skeiky , Davin Dillon , Mark Alderson , Antonio Campos-Neto
发明人： Steven Reed , Yasir Skeiky , Davin Dillon , Mark Alderson , Antonio Campos-Neto
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/55505 , C07K14/35 , C07K2319/00 , C07K2319/40 , C12N15/62
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
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公开(公告)号：US06544522B1
公开(公告)日：2003-04-08
申请号：US09223040
申请日：1998-12-30
申请人： Yasir Skeiky , Mark Alderson , Antonio Campos-Neto
发明人： Yasir Skeiky , Mark Alderson , Antonio Campos-Neto
IPC分类号： A61K3902
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The present invention relates to fusion proteins of Mycobacterium tuberclosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.
摘要翻译： 本发明涉及结核分枝杆菌抗原的融合蛋白。 特别涉及两种融合蛋白，其中每种融合蛋白含有三种单独的结核分枝杆菌抗原，以及两种结核分枝杆菌抗原的融合蛋白，其编码序列及其用于治疗和预防结核病的方法。
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公开(公告)号：US20060034764A1
公开(公告)日：2006-02-16
申请号：US11201519
申请日：2005-08-10
申请人： Steven Reed , Yasir Skeiky , Davin Dillon , Mark Alderson , Antonio Campos-Neto
发明人： Steven Reed , Yasir Skeiky , Davin Dillon , Mark Alderson , Antonio Campos-Neto
CPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/55505 , C07K14/35 , C07K2319/00 , C07K2319/40 , C12N15/62
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
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公开(公告)号：US07935353B2
公开(公告)日：2011-05-03
申请号：US11476254
申请日：2006-06-27
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US20160222070A1
公开(公告)日：2016-08-04
申请号：US14849531
申请日：2015-09-09
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US07927610B2
公开(公告)日：2011-04-19
申请号：US11929022
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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公开(公告)号：US07087713B2
公开(公告)日：2006-08-08
申请号：US09793306
申请日：2001-02-26
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US20130052229A1
公开(公告)日：2013-02-28
申请号：US13560514
申请日：2012-07-27
IPC分类号： A61K39/04 , A61P31/06 , C07K19/00 , C07H21/04 , A61K31/711
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US07927611B2
公开(公告)日：2011-04-19
申请号：US11929064
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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