公开(公告)号：US4339585A

公开(公告)日：1982-07-13

申请号：US959163

申请日：1978-11-09

申请人： Shingo Matsumura ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoji Ezure ,  Yoshiaki Yoshikuni ,  Masahiro Yagi

发明人： Shingo Matsumura ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoji Ezure ,  Yoshiaki Yoshikuni ,  Masahiro Yagi

IPC分类号： C07D211/46

CPC分类号： C07D211/46

摘要： Moranoline, or 2-hydroxymethyl-3,4,5-trihydroxy piperidine, is prepared by directly reducing an actinomycetes culture solution containing nojirimycin, followed by isolation, as for example, through the utilization of an ion exchange resin. The corresponding N-methyl derivative can be obtained through the addition of formaldehyde to the culture solution prior to the reduction.

摘要翻译： 通过直接还原含有异丙霉素的放线菌培养液，然后分离，例如通过使用离子交换树脂来制备山梨醇或2-羟甲基-3,4,5-三羟基哌啶。 相应的N-甲基衍生物可以通过在还原之前向培养液中加入甲醛来获得。

公开(公告)号：US4336373A

公开(公告)日：1982-06-22

申请号：US247885

申请日：1981-03-26

申请人： Shingo Matsumura ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoshiaki Yoshikuni ,  Masahiro Yagi ,  Kohei Kura ,  Ichiro Shirahase

发明人： Shingo Matsumura ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoshiaki Yoshikuni ,  Masahiro Yagi ,  Kohei Kura ,  Ichiro Shirahase

IPC分类号： A61K31/445 ,  A61P3/08 ,  A61P3/10 ,  C07D211/46 ,  C07D401/10 ,  C07D401/12

CPC分类号： C07D211/46 ,  Y10S514/866

摘要： Bis(2-hydroxymethyl-3,4,5-trihydroxypiperidine-1-yl-propenyl) compounds and their acid addition salts are antihyperglycemic agents. Typical examples are 1,4-bis[3-(2-hydroxymethyl-3,4,5-trihydroxypiperidin-1-yl)prop-2-enyl] benzene and 1,3-bis-{4-[3-(2-hydroxymethyl-3,4,5-trihydroxy-piperidin-1-yl)prop-2-enyl]phenoxy}propane.

摘要翻译： 双（2-羟甲基-3,4,5-三羟基哌啶-1-基 - 丙烯基）化合物及其酸加成盐是抗高血糖药。 典型的实例是1,4-双[3-（2-羟甲基-3,4,5-三羟基哌啶-1-基）丙-2-烯基]苯和1,3-双 - {4- [3-（2 丙-2-烯基]苯氧基}丙烷。

公开(公告)号：USRE30886E

公开(公告)日：1982-03-23

申请号：US969785

申请日：1978-12-15

申请人： Katsuya Ohata ,  Hiroshi Enomoto ,  Yoshiaki Yoshikuni ,  Tatsuhiko Kono ,  Masahiro Yagi

发明人： Katsuya Ohata ,  Hiroshi Enomoto ,  Yoshiaki Yoshikuni ,  Tatsuhiko Kono ,  Masahiro Yagi

IPC分类号： C07D211/46

CPC分类号： C07D211/46

摘要： 2-Hydroxymethyl-3,4,5-trihydroxypiperidine possesses antidiabetic and lipid biosynthesis inhibitory properties. The use of the compound for such indications and pharmaceutical compositions adapted to this use are described.

公开(公告)号：US4241064A

公开(公告)日：1980-12-23

申请号：US083419

申请日：1979-10-10

申请人： Shingo Matsumura ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoshitsugu Nomiyama ,  Tatsuhiko Kono ,  Masato Matsuda ,  Haruo Tanaka

发明人： Shingo Matsumura ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoshitsugu Nomiyama ,  Tatsuhiko Kono ,  Masato Matsuda ,  Haruo Tanaka

IPC分类号： A61K31/435 ,  A61P19/06 ,  C07D471/04 ,  A61K31/395

CPC分类号： C07D471/04

摘要： 1-Substituted-9H-pyrido[3,4-b]indole derivatives, which are further optionally substituted in the 3- or 4-position, are inhibitors of xanthine-oxidase. A representative embodiment is 1-formyl-4-hydroxy-9H-pyrido[3,4-b]indole which can be prepared through the processing of Picrasma quassioides.

摘要翻译： 在3-或4-位进一步任选取代的1-取代的-9H-吡啶并[3,4-b]吲哚衍生物是黄嘌呤氧化酶的抑制剂。 代表性的实施方案是1-甲酰基-4-羟基-9H-吡啶并[3,4-b]吲哚，其可以通过加工皮卡西菌素制备。

公开(公告)号：US09765977B2

公开(公告)日：2017-09-19

申请号：US13496245

申请日：2010-09-28

申请人： Masashi Fujitsuka ,  Hiroshi Enomoto ,  Motohiko Kawagishi ,  Kazuhiko Kawajiri ,  Minoru Sato ,  Shunkei Suzuki

发明人： Masashi Fujitsuka ,  Hiroshi Enomoto ,  Motohiko Kawagishi ,  Kazuhiko Kawajiri ,  Minoru Sato ,  Shunkei Suzuki

IPC分类号： F24D11/00 ,  F24D11/02 ,  F24F5/00 ,  F24D19/10 ,  F25B13/00 ,  F25B25/00

CPC分类号： F24D11/0214 ,  F24D19/1039 ,  F24F5/0017 ,  F24F5/0096 ,  F24F2005/0025 ,  F24F2221/183 ,  F24F2221/54 ,  F25B13/00 ,  F25B25/005 ,  F25B2313/02741 ,  F25B2400/24 ,  Y02B30/125 ,  Y02E60/147

摘要： A first circulation channel connects a first heat demand part and first supply heat exchanger with its forward route and return route. Supply and discharge channels are connected to a first heat accumulation tank, which accommodates a second heat medium heated in the first supply heat exchanger and supplied via the supply channel. A heat accumulation switching valve changes over communication of the second heat medium serving as hot heat or cold heat flowing from the first supply heat exchanger and supplied to the first heat demand part without branching to the supply channel or branching to the supply channel and supplied to the first heat accumulation tank. A heat-accumulating hot-water-supplying air conditioner operates at a first temperature when the second heat medium from the first supply heat exchanger branches to the supply channel, and at a second lower temperature when the second heat medium does not branch to the supply channel.

公开(公告)号：US08193237B2

公开(公告)日：2012-06-05

申请号：US12448826

申请日：2008-01-15

申请人： Hiroshi Enomoto ,  Kenji Kawashima ,  Kazuhiro Kudou ,  Minoru Yamamoto ,  Masaaki Murai ,  Takaaki Inaba ,  Noriko Ishizaka

发明人： Hiroshi Enomoto ,  Kenji Kawashima ,  Kazuhiro Kudou ,  Minoru Yamamoto ,  Masaaki Murai ,  Takaaki Inaba ,  Noriko Ishizaka

IPC分类号： A61K31/404 ,  C07D209/12

CPC分类号： C07D209/42 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

摘要： Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKKβ and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; R2 represents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like.

摘要翻译： 公开了由通式（1）表示的化合物或其盐。 该化合物或其盐对IKK＆bgr具有抑制活性; 因此可用作与IKK＆bgr相关的疾病的预防和/或治疗剂。 在该式中，R 1表示氢原子，低级烷基，芳基，羟基等; R2表示卤素原子，低级烷基，低级烯基，低级炔基等; m表示0,1,2等。

公开(公告)号：US07977371B2

公开(公告)日：2011-07-12

申请号：US12449794

申请日：2008-02-26

申请人： Kenji Kawashima ,  Hiroshi Enomoto ,  Noriko Ishizaka ,  Minoru Yamamoto ,  Kazuhiro Kudou ,  Masaaki Murai ,  Takaaki Inaba ,  Kazuyoshi Okamoto

发明人： Kenji Kawashima ,  Hiroshi Enomoto ,  Noriko Ishizaka ,  Minoru Yamamoto ,  Kazuhiro Kudou ,  Masaaki Murai ,  Takaaki Inaba ,  Kazuyoshi Okamoto

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/422 ,  A61K31/403 ,  A61K31/4025 ,  A61K31/40 ,  C07D417/12 ,  C07D413/12 ,  C07D409/04 ,  C07D405/12 ,  C07D407/10 ,  C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/10

CPC分类号： C07D207/34 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D417/12

摘要： Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.

摘要翻译： 本发明的目的是研究具有脲基和氨基羰基作为取代基或其盐的新型吡咯衍生物的合成，以发现其衍生物或其盐的药理作用，并找到药剂 其通过口服给药对视网膜疾病等具有预防和/或治疗作用。 由通式（1）表示的化合物或其盐对白介素-6的产生具有抑制活性和/或对脉络膜新生血管形成的抑制作用，因此可用作疾病的预防和/或治疗剂 与白介素-6相关，眼炎和/或视网膜疾病。 在该式中，环A表示苯环等; R1表示卤素原子，氢原子，低级烷基等; R 2表示卤原子，可以具有取代基的低级烷基，低级烯基，可具有取代基的低级炔基，低级环烷基，芳基，羟基，可以具有取代基的低级烷氧基 具有取代基等; n表示0,1,2,3等。

公开(公告)号：US20100099675A1

公开(公告)日：2010-04-22

申请号：US12449794

申请日：2008-02-26

申请人： Kenji Kawashima ,  Hiroshi Enomoto ,  Noriko Ishizaka ,  Minoru Yamamoto ,  Kazuhiro Kudou ,  Masaaki Murai ,  Takaaki Inaba ,  Kazuyoshi Okamoto

发明人： Kenji Kawashima ,  Hiroshi Enomoto ,  Noriko Ishizaka ,  Minoru Yamamoto ,  Kazuhiro Kudou ,  Masaaki Murai ,  Takaaki Inaba ,  Kazuyoshi Okamoto

IPC分类号： A61K31/5377 ,  C07D207/00 ,  A61K31/40 ,  C07D401/02 ,  A61K31/4439 ,  C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  A61K31/497 ,  C07D413/12

CPC分类号： C07D207/34 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D417/12

摘要： Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.

摘要翻译： 本发明的目的是研究具有脲基和氨基羰基作为取代基或其盐的新型吡咯衍生物的合成，以发现其衍生物或其盐的药理作用，并找到药剂 其通过口服给药对视网膜疾病等具有预防和/或治疗作用。 由通式（1）表示的化合物或其盐对白介素-6的产生具有抑制活性和/或对脉络膜新生血管形成的抑制作用，因此可用作疾病的预防和/或治疗剂 与白介素-6相关，眼炎和/或视网膜疾病。 在该式中，环A表示苯环等; R1表示卤素原子，氢原子，低级烷基等; R 2表示卤原子，可以具有取代基的低级烷基，低级烯基，可具有取代基的低级炔基，低级环烷基，芳基，羟基，可以具有取代基的低级烷氧基 具有取代基等; n表示0,1,2,3等。

公开(公告)号：US20090265084A1

公开(公告)日：2009-10-22

申请号：US11989317

申请日：2006-07-21

申请人： Hiroshi Enomoto

发明人： Hiroshi Enomoto

IPC分类号： G06F19/00

CPC分类号： F02D41/0055 ,  F02D41/042 ,  F02D2011/108 ,  F02D2250/16 ,  F02M26/48 ,  F02M26/49 ,  F02M26/50 ,  F02M26/54 ,  F02M26/70 ,  F02M26/73 ,  Y02T10/47

摘要： A valve control device performs control for eliminating or preventing fixation of an EGR valve (30) by opening/closing the valve near its fully closed position. After an engine stops, the valve control device performs “a fixation avoiding operation” for opening/closing EGR valve (30) near the fully closed position, and further, performs “a fixation determining operation”. When it is determined that the fixation of EGR valve (30) is eliminated, EGR valve (30) is positioned at the fully closed position, and a reference position is corrected such that the fully closed position is regarded as a reference position at which a valve opening/closing control is performed during the operation of the engine.

摘要翻译： 阀控制装置通过在其完全关闭位置附近打开/关闭阀来执行用于消除或防止EGR阀（30）的固定的控制。 发动机停止后，阀控制装置在完全关闭位置附近进行用于打开/关闭EGR阀（30）的“固定避免操作”，并且进行“固定确定操作”。 当确定EGR阀（30）的固定被消除时，EGR阀（30）位于完全关闭位置，并且校正基准位置使得完全关闭位置被认为是基准位置 在发动机运转期间进行阀门开/关控制。

公开(公告)号：US20090164106A1

公开(公告)日：2009-06-25

申请号：US12065552

申请日：2006-08-30

申请人： Hiroshi Enomoto

发明人： Hiroshi Enomoto

IPC分类号： F02D45/00

CPC分类号： F02D41/042 ,  F02D41/0055 ,  F02D2011/108 ,  F02M26/11 ,  F02M26/48 ,  F02M26/50 ,  F02M26/54 ,  F02M26/70 ,  F02M26/73 ,  Y02T10/47

摘要： A valve control apparatus of a diesel engine (1) is provided with an EGR valve (30), which is provided in an EGR passage (26) of the engine (1) and varies the flow rate of exhaust gas flowing through a passage (26) by carrying out an opening and closing motion, and an actuator (28), which executes a sticking avoiding operation for dissolving or preventing a sticking of a valve (30) by causing the valve (30) to move to and fro so as to open and close the valve (30) by a predetermined moving amount respectively in one direction and the other direction near a full-close position of the valve (30). The apparatus inhibits the sticking avoiding operation by the actuator (28) when an ignition OFF operation is carried out without starting an operation of the engine (1) after an ignition ON operation is carried out. As a result, it is possible to prevent a useless valve opening and closing motion and achieve power saving.

摘要翻译： 柴油发动机（1）的阀控制装置设置有EGR阀（30），其设置在发动机（1）的EGR通路（26）中，并且改变流过通道的排气流量（ 26），以及致动器（28），其执行用于通过使阀（30）来回移动来溶解或防止阀（30）的粘附的粘附避免操作，以便 分别在阀（30）的完全关闭位置附近的一个方向和另一个方向上打开和关闭阀（30）预定的移动量。 在执行点火ON操作之后，当进行点火OFF操作而不启动发动机（1）的操作时，该装置禁止致动器（28）的防止操作。 结果，可以防止无用的阀开闭动作，实现省电。