Methods for Identifying Modulators of Insect Transient Receptor Potential Channels

    公开(公告)号:US20230176038A1

    公开(公告)日:2023-06-08

    申请号:US17787968

    申请日:2020-12-10

    CPC classification number: G01N33/5041 G01N2333/43552

    Abstract: The present invention relates to a screening method for determining whether or not a candidate compound is a modulator of a complex consisting of the insect transient receptor potential channel Nanchung protein and the insect transient receptor potential channel Water witch protein. The present invention further relates to a screening method for determining whether or not a candidate compound directly binds to the complex consisting of the Nanchung protein and Water witch protein. The present invention further relates to a screening method for determining whether or not a candidate compound is a modulator of the insect Water witch protein. The present invention further provides a method of insect control by applying an insect-specific TRP channel modulator determined by the screening method. The present invention further provides a method of classifying an insecticide compound by its mode of action using the binding assay and/or a functional assay.

    Evaporative emission control articles including activated carbon

    公开(公告)号:US11624340B2

    公开(公告)日:2023-04-11

    申请号:US16534177

    申请日:2019-08-07

    Abstract: The present disclosure relates to hydrocarbon emission control systems. More specifically, the present disclosure relates to substrates coated with hydrocarbon adsorptive coating compositions and evaporative emission control systems for controlling evaporative emissions of hydrocarbons from motor vehicle engines and fuel systems. The hydrocarbon adsorptive coating compositions include particulate carbon having a BET surface area of at least about 1300 m2/g, and at least one of (i) a butane affinity of greater than 60% at 5% butane; (ii) a butane affinity of greater than 35% at 0.5% butane; (iii) a micropore volume greater than about 0.2 mug and a mesopore volume greater than about 0.5 ml/g.

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