公开(公告)号：US20130116398A1

公开(公告)日：2013-05-09

申请号：US13701581

申请日：2011-06-10

Applicant: Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian T. Keen ,  Brooke A. Albin ,  Nye A. Clinton ,  Bernard D. Dombek

Inventor： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian T. Keen ,  Brooke A. Albin ,  Nye A. Clinton ,  Bernard D. Dombek

IPC: C07D223/10 ,  C12P17/10

CPC classification number: C07D223/10 ,  C12P7/44 ,  C12P17/10

Abstract: Processes for making caprolactam (CL) from monoammonium adipate (MAA) and/or adipic aicd (AA) obtained from a clarified diammonium adipate-containing (DAA-containing) fermentation broth or MAA-containing fermentation broth and converting the MAA or AA to the CL with hydrogen in the presence of a catalyst at selected temperatures and pressures.

Abstract translation: 从含有己二酸二铵（含DAA）发酵液或含MAA的发酵液获得的由己二酸单铵（MAA）和/或己二酸（AA）制备己内酰胺（CL）的方法，并将MAA或AA转化为 CL在催化剂存在下在选定的温度和压力下进行。

公开(公告)号：US20110269993A1

公开(公告)日：2011-11-03

申请号：US13087001

申请日：2011-04-14

Applicant: Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian T. Keen ,  Brooke A. Albin ,  Nye A. Clinton ,  Bernard D. Dombek

Inventor： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian T. Keen ,  Brooke A. Albin ,  Nye A. Clinton ,  Bernard D. Dombek

IPC: C07C51/44 ,  C07C51/46

CPC classification number: C07C51/02 ,  C07C51/46 ,  C12P7/46 ,  C07C55/14

Abstract: Processes for making AA from either a clarified DAA-containing fermentation broth or a clarified MAA-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that includes AA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure AA; and separating the solid portion from the liquid portion. A method also reduces the broth distillation temperature and pressure by adding an ammonia separating and/or water azeotroping solvent to the broth.

Abstract translation: 用于从含有澄清的含DAA的发酵液或含有澄清的含MAA的发酵液中制备AA的方法，其包括在超大气压下在> 100℃至约300℃的温度下蒸馏所述肉汤，以形成塔顶馏出物 包括水和氨，以及包含AA和至少约20重量％水的液体底部物质; 将塔底部分冷却到足以使底部分离成液体部分的温度和基本上纯的AA的固体部分; 并将固体部分与液体部分分离。 一种方法还通过向肉汤中加入氨分离和/或水共沸溶剂来降低肉汤蒸馏温度和压力。

公开(公告)号：US20110245515A1

公开(公告)日：2011-10-06

申请号：US13051688

申请日：2011-03-18

Applicant: Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

Inventor： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC: C07D307/33 ,  C07C29/74 ,  C07D307/08

CPC classification number: C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07D307/33 ,  C07C31/207 ,  C07C55/10

Abstract: A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.

Abstract translation: 制备氢化产物的方法包括提供澄清的含DAS的发酵液，蒸馏培养液以形成包含水和氨的塔顶馏出物，以及液体塔底物，其包括MAS，至少一些DAS和至少约20wt％ 水，冷却和/或蒸发塔底物，以及任选地向塔底物中加入抗溶剂，以获得足以使塔底物分离成含有DAS的液体部分的温度和组合物，以及基本上没有的含MAS的固体部分 的DAS，将固体部分与液体部分分离，回收固体部分，在至少一种氢化催化剂的存在下氢化第二固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物，并回收 氢化产物。