公开(公告)号：US08193375B2

公开(公告)日：2012-06-05

申请号：US13213565

申请日：2011-08-19

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/00 ,  C07D305/00 ,  C07C27/04

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07D307/33 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液，蒸馏培养液以形成包含水和氨的塔顶馏出物，以及液体塔底物，其包括MAS，至少一些DAS和至少约20wt％ 水，冷却和/或蒸发塔底物，以及任选地向塔底物中加入抗溶剂，以获得足以使塔底物分离成含有DAS的液体部分的温度和组合物，以及基本上没有的含MAS的固体部分 的DAS，将固体部分与液体部分分离，回收固体部分，在至少一种氢化催化剂的存在下氢化第二固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物，并回收 氢化产物。

公开(公告)号：US08466300B2

公开(公告)日：2013-06-18

申请号：US13051579

申请日：2011-03-18

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/00 ,  C07D305/00 ,  C07C27/04

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07C51/46 ,  C07D307/32 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液; 在超大气压下在> 100℃至约300℃的温度下蒸馏肉汤以形成包含水和氨的塔顶馏出物，以及包含SA和至少约20重量％水的液体塔底物; 将底部冷却至足以使底部分离成与基本上纯的SA的固体部分接触的液体部分的温度; 从液体部分分离固体部分; 回收固体部分; 在至少一种氢化催化剂存在下氢化固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物; 并回收氢化产物。

公开(公告)号：US20120215014A1

公开(公告)日：2012-08-23

申请号：US13458121

申请日：2012-04-27

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/20 ,  C07D307/08 ,  C07C27/04

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07D307/33 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液，蒸馏培养液以形成包含水和氨的塔顶馏出物，以及液体塔底物，其包括MAS，至少一些DAS和至少约20wt％ 水，冷却和/或蒸发塔底物，以及任选地向塔底物中加入抗溶剂，以获得足以使塔底物分离成含有DAS的液体部分的温度和组合物，以及基本上没有的含MAS固体部分 的DAS，将固体部分与液体部分分离，回收固体部分，在至少一种氢化催化剂的存在下氢化第二固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物，并回收 氢化产物。

公开(公告)号：US20110245515A1

公开(公告)日：2011-10-06

申请号：US13051688

申请日：2011-03-18

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/33 ,  C07C29/74 ,  C07D307/08

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07D307/33 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液，蒸馏培养液以形成包含水和氨的塔顶馏出物，以及液体塔底物，其包括MAS，至少一些DAS和至少约20wt％ 水，冷却和/或蒸发塔底物，以及任选地向塔底物中加入抗溶剂，以获得足以使塔底物分离成含有DAS的液体部分的温度和组合物，以及基本上没有的含MAS的固体部分 的DAS，将固体部分与液体部分分离，回收固体部分，在至少一种氢化催化剂的存在下氢化第二固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物，并回收 氢化产物。

公开(公告)号：US08410291B2

公开(公告)日：2013-04-02

申请号：US13051688

申请日：2011-03-18

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/00 ,  C07D305/00 ,  C07C27/04

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07D307/33 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液，蒸馏培养液以形成包含水和氨的塔顶馏出物，以及液体塔底物，其包括MAS，至少一些DAS和至少约20wt％ 水，冷却和/或蒸发塔底物，以及任选地向塔底物中加入抗溶剂，以获得足以使塔底物分离成含有DAS的液体部分的温度和组合物，以及基本上没有的含MAS的固体部分 的DAS，将固体部分与液体部分分离，回收固体部分，在至少一种氢化催化剂的存在下氢化第二固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物，并回收 氢化产物。

公开(公告)号：US08084626B1

公开(公告)日：2011-12-27

申请号：US13213677

申请日：2011-08-19

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/00 ,  C07D305/00 ,  C07C27/04

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07C51/46 ,  C07D307/32 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液; 在超大气压下在> 100℃至约300℃的温度下蒸馏肉汤以形成包含水和氨的塔顶馏出物，以及包含SA和至少约20重量％水的液体塔底物; 将底部冷却至足以使底部分离成与基本上纯的SA的固体部分接触的液体部分的温度; 从液体部分分离固体部分; 回收固体部分; 在至少一种氢化催化剂存在下氢化固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物; 并回收氢化产物。

公开(公告)号：US20110306777A1

公开(公告)日：2011-12-15

申请号：US13213677

申请日：2011-08-19

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/33 ,  C07C29/149 ,  C07D307/08

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07C51/46 ,  C07D307/32 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.

公开(公告)号：US20110301364A1

公开(公告)日：2011-12-08

申请号：US13213565

申请日：2011-08-19

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D305/12 ,  C07C27/04 ,  C07D307/04

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07D307/33 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.

公开(公告)号：US20110245514A1

公开(公告)日：2011-10-06

申请号：US13051579

申请日：2011-03-18

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian Terry Keen ,  Brooke Ashley Albin ,  Nye A. Clinton ,  Bernard Duane Dombek

IPC分类号： C07D307/20 ,  C07D307/08 ,  C07C29/74

CPC分类号： C07D307/08 ,  C07C29/149 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C51/445 ,  C07C51/46 ,  C07D307/32 ,  C07C31/207 ,  C07C55/10

摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.

摘要翻译： 制备氢化产物的方法包括提供澄清的含DAS的发酵液; 在超大气压下在> 100℃至约300℃的温度下蒸馏肉汤以形成包含水和氨的塔顶馏出物，以及包含SA和至少约20重量％水的液体塔底物; 将底部冷却至足以使底部分离成与基本上纯的SA的固体部分接触的液体部分的温度; 从液体部分分离固体部分; 回收固体部分; 在至少一种氢化催化剂存在下氢化固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物; 并回收氢化产物。

公开(公告)号：US09115080B2

公开(公告)日：2015-08-25

申请号：US13701622

申请日：2011-06-10

申请人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian T. Keen ,  Brooke A. Albin ,  Nye A. Clinton ,  Bernard D. Dombek

发明人： Olan S. Fruchey ,  Leo E. Manzer ,  Dilum Dunuwila ,  Brian T. Keen ,  Brooke A. Albin ,  Nye A. Clinton ,  Bernard D. Dombek

IPC分类号： C07D223/10 ,  C12P7/44 ,  C12P17/10 ,  C07D201/08

CPC分类号： C07D201/08 ,  C07D223/10 ,  C12P7/44 ,  C12P17/10

摘要： Processes for producing caprolactam (CL) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA).

摘要翻译： 从含有己二酸二铵（DAA）或己二酸单铵（MAA）的发酵液获得的己二酸（AA）制备己内酰胺（CL）及其衍生物的方法。