-
公开(公告)号：US09968592B2
公开(公告)日：2018-05-15
申请号：US15513277
申请日：2015-09-28
Applicant: KOWA COMPANY, LTD.
Inventor： Yuta Inokuchi , Haruki Shibata , Toshiaki Takizawa
IPC: A61K31/423 , A61K31/4152 , A61K45/06 , A61K45/00
CPC classification number: A61K31/423 , A61K31/4152 , A61K31/421 , A61K31/505 , A61K45/00 , A61K45/06 , A61K2300/00
Abstract: This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemic conditions such as hyper-LDL cholesterolemia in mammals, including humans.This invention pertains to a drug composition for preventing and/or treating dyslipidemia and the like, the drug composition including the following: (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] butyric acid, a salt thereof, or a solvate of either; and (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methyl sulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl} acetic acid, a salt thereof, or a solvate of either.
-
公开(公告)号：US09855138B2
公开(公告)日：2018-01-02
申请号：US14648119
申请日：2013-11-29
Applicant: KOWA COMPANY, LTD.
Inventor： Kenichi Kobayashi
CPC classification number: A61F2/167 , A61F2/1678
Abstract: The intraocular lens insertion tool includes a nozzle main body having a nozzle portion 15, a stage portion capable of disposing the intraocular lens 2 in the nozzle main body, and a plunger 60 that presses the intraocular lens 2 set in the stage portion by a leading end, thereby releasing the intraocular lens 2 into an eyeball. The leading end portion 10a of the nozzle portion 15 is obliquely cut so that, as it goes to the front side from the optical axis rear side of intraocular lens 2, the position of the end surface is located on the front side, and at the leading end 61d of the plunger 60, a protruding portion 61e is provided which protrudes to the front side so as to be able to place the surface of the optical axis rear side of the intraocular lens 2.
-
公开(公告)号：US20170360799A1
公开(公告)日：2017-12-21
申请号：US15534069
申请日：2015-12-11
Applicant: KOWA COMPANY, LTD.
Inventor： Isamu SAWAI
IPC: A61K31/551 , A61K31/10 , A61K9/08 , A61K31/473 , A61K9/00
CPC classification number: A61K31/551 , A61K9/0048 , A61K9/08 , A61K31/10 , A61K31/473 , A61K31/498 , A61K31/5513 , A61K47/22 , A61P27/06 , A61K2300/00
Abstract: A technique is provided for suppressing the crystal precipitation of an aqueous composition containing a halogenated isoquinoline derivative during low-temperature preservation. An aqueous composition comprising a compound represented by Formula (1): wherein x represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, and brimonidine or a salt thereof.
-
公开(公告)号：US09820649B2
公开(公告)日：2017-11-21
申请号：US15300191
申请日：2015-03-30
Applicant: KOWA COMPANY, LTD.
Inventor： Toshiaki Nakagawa , Yoshihiro Kakutani , Masaharu Mizuochi
CPC classification number: A61B3/1225 , A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/103
Abstract: A three-dimensional tomographic image (B) is formed which is composed of a plurality of two-dimensional tomographic images obtained by scanning an ocular fundus. A contour of a certain 2D region (M1, M2, M3, M4) in the tomographic image is determined for each tomographic image, and the volume of a certain 3D region is calculated through correcting each area of the certain 2D region defined by the determined contour or its accumulated value using an image correction coefficient in accordance with the diopter of the subject's eye. Even for subjects' eyes of different diopters, the influence of the diopter correction is eliminated and a quantitative comparison of subjects' eyes of different diopters is possible.
-
公开(公告)号：US20170266080A1
公开(公告)日：2017-09-21
申请号：US15514020
申请日：2015-09-25
Applicant: KOWA COMPANY, LTD.
Inventor： Shin SUGIMOTO
IPC: A61J1/14 , A61K9/08 , A61K31/551
CPC classification number: A61J1/1468 , A61K9/08 , A61K31/551
Abstract: A technique is provided for suppressing discoloration of an aqueous composition containing a halogenated isoquinoline derivative during preservation at high temperature. A pharmaceutical preparation obtained by storing an aqueous composition comprising a compound represented by Formula (1), wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, in a container made of polyolefin-based resin.
-
Patent Agency Ranking
公开(公告)号：US20170252338A1
公开(公告)日：2017-09-07
申请号：US15528630
申请日：2015-11-27
Applicant: KOWA COMPANY, LTD.
Inventor： Haruki SHIBATA
IPC: A61K31/505 , A61K31/47
CPC classification number: A61K31/505 , A61K31/47 , A61K45/00
Abstract: A medicine for lowering LDL cholesterol is provided. A medicine for lowering LDL cholesterol, the medicine comprising a combination of a statin and (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl) ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, a salt thereof, or a solvate of the compound or the salt.
-
公开(公告)号：US09693857B2
公开(公告)日：2017-07-04
申请号：US13993638
申请日：2011-12-01
Applicant: Akinori Marunaka , Toshihide Tanaka , Yuji Nagura , Shuji Abe
Inventor： Akinori Marunaka , Toshihide Tanaka , Yuji Nagura , Shuji Abe
IPC: A61F2/16
CPC classification number: A61F2/167 , A61F2/1662 , A61F2/1691 , A61F2002/1682 , A61F2002/16905
Abstract: Provided is technology which can prevent plunger deformation and further stabilize an intraocular lens insertion operation, even when an insertion tube section of an intraocular lens insertion apparatus has been further reduced in terms of the diameter thereof and has been made flatter. The intraocular lens insertion apparatus includes: a tip end region where a plunger comes into contact with an intraocular lens main body and an intraocular lens holding section; and a bar-shaped section extending from the rear end of this tip end region to the rear of the plunger. The bar-shaped section has a fixed thickness in the direction of the optical axis of the intraocular lens, and has an increasing thickness in a portion where the distance from the tip end of the tip end region is equal to or greater than a predetermined distance in a direction perpendicular to the optical axis direction and perpendicular to the plunger advancement direction.
-
公开(公告)号：US09682913B2
公开(公告)日：2017-06-20
申请号：US14780625
申请日：2014-03-28
Applicant: KOWA COMPANY, LTD.
Inventor： Yukiyoshi Yamazaki
IPC: C07B57/00 , C07C51/41 , A61K31/423 , C07D263/58 , C07C67/08
CPC classification number: C07C51/412 , A61K31/423 , C07B57/00 , C07C67/08 , C07D263/58 , C07C51/487 , C07C59/01
Abstract: To provide a method for improving optical purity of an optically active 2-hydroxycarboxylic acid or a derivative thereof, which is useful as a raw material in the manufacture of medicines, agrochemicais, and industrial products. The method of the invention for improving purity of a hydroxycarboxylic acid of the following formula (1a) or (1b) or a derivative thereof includes the steps of reacting the hydroxycarboxylic acid of the following formula (1a) or (1b) with at least one optically inactive base selected from the group consisting of an alkali metal, alkoxide and a secondary amine in the presence of a solvent and, subsequently, performing recrystallization, to thereby form a hydroxycarboxylic acid salt of the following formula (IIIa) or (IIIb): wherein R1 represents a C1-8 alkyl group, and R2 represents an alkali metal or a secondary amine.
-
公开(公告)号：US09681943B2
公开(公告)日：2017-06-20
申请号：US14913075
申请日：2014-09-02
Applicant: KOWA COMPANY, LTD.
Inventor： Yutaka Kumazawa , Kotaro Sakanishi , Atsushi Kobayashi
IPC: A61F2/16
CPC classification number: A61F2/16 , A61F2/1613 , A61F2002/1683 , A61F2002/169 , A61F2002/16901
Abstract: An intraocular lens wherein an outer edge of a support part has a curved concave shape at a base thereof and extends therefrom toward a tip thereof with a curved convex shape having a radius of curvature of 5.25 to 7.50 mm. In a region where a Y coordinate of an orthogonal coordinate system is 1.0 mm or greater, an origin of the coordinate system being a geometric center of an optical part, an inner edge of the support part is positioned between shapes obtained by offsetting the outer edge of the support part by 0.2 mm and by 1.0 mm towards the X-axis origin. The tip of the support part is positioned in a region where the Y coordinate is greater than a radius of the optical part, outside a circle with a radius of 5.0 mm centered on the origin.
-
公开(公告)号：US20170135842A1
公开(公告)日：2017-05-18
申请号：US15322927
申请日：2015-07-01
Applicant: KOWA COMPANY, LTD. , ADVANCING INC. , DMCHAIN COOPERATIVE
Inventor： Akiharu TSUCHIYA , Hitoshi OJIMA , Hidenori KASENO
IPC: A61F5/02
Abstract: Provided is a supporter in which it is possible to prevent floating of the supporter from the back portion of a wearer of the supporter in an upper side and a lower side of a back-contact section having a wide width and reliably support the waist portion of the wearer. The supporter 100 comprises: a band-shaped body section 10 provided with a back-contact section 11 which is brought into contact with the back portion of a wearer, and protruding sections 12 protruding to the right and left from both sides of the back-contact section 11; a pair of right and left auxiliary band sections 31 and 32 fixed so as to intersect one another in the vicinity of an upper side 11a of the back-contact section 11; a pair of right and left adjustment band sections 51 and 52 loosely inserted into annular rings 41 and 42 respectively disposed at the auxiliary band sections 31 and 32; and a band-shaped support band section 70 fixed to the vicinity of a lower side 11b of the back-contact section 11.
-
-
-
-
-
-
-
-
-
Search Results
671
records
(took 0.032 seconds)
