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公开(公告)号：US08241674B2
公开(公告)日：2012-08-14
申请号：US12030335
申请日：2008-02-13
申请人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
发明人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
CPC分类号： C07D309/24 , A61K31/00 , A61K31/121 , A61K31/122 , A61K31/365 , A61K33/30 , C07C49/255 , C07C49/707 , C07C49/743 , A61K2300/00
摘要： Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
摘要翻译： 描述了用于增强重金属解毒的组合物和方法。 所述的组合物和方法提供了关键解毒系统的增强的活性，包括诱导II期解毒酶，例如谷胱甘肽S-转移酶（GST）和NADPH醌还原酶（NQO1）活性。
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公开(公告)号：US20120189721A1
公开(公告)日：2012-07-26
申请号：US13352831
申请日：2012-01-18
申请人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
发明人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
CPC分类号： C07D309/24 , A61K31/00 , A61K31/121 , A61K31/122 , A61K31/365 , A61K33/30 , C07C49/255 , C07C49/707 , C07C49/743 , A61K2300/00
摘要： Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
摘要翻译： 描述了用于增强重金属解毒的组合物和方法。 所述的组合物和方法提供了关键解毒系统的增强的活性，包括诱导II期解毒酶，例如谷胱甘肽S-转移酶（GST）和NADPH醌还原酶（NQO1）活性。
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33.发明申请公开(公告)号：US20120183634A1
公开(公告)日：2012-07-19
申请号：US13430154
申请日：2012-03-26
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
CPC分类号： A61K31/122 , A61K31/12 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
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公开(公告)号：US07820206B2
公开(公告)日：2010-10-26
申请号：US11344554
申请日：2006-01-30
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/12
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
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公开(公告)号：US07722903B2
公开(公告)日：2010-05-25
申请号：US11344559
申请日：2006-01-30
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/12
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.
摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。
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公开(公告)号：US07718198B2
公开(公告)日：2010-05-18
申请号：US11326874
申请日：2006-01-06
申请人： Matthew Tripp , Jeffrey S. Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
发明人： Matthew Tripp , Jeffrey S. Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/12 , A61K36/53 , A61K45/06 , A61K2300/00
摘要： Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
摘要翻译： 公开了还原的异α酸，维生素和矿物质的组合物以及使用其来治疗自身免疫性疾病的方法。 还考虑了包括其它化合物的其它组合。 还公开了利用这种协同作用的协同性质和方法。
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37.发明授权Compositions that treat or inhibit pathological conditions associated with inflammatory response 有权治疗或抑制与炎症反应相关的病理状况的组合物公开(公告)号：US07431948B2
公开(公告)日：2008-10-07
申请号：US11403016
申请日：2006-04-12
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K36/185 , A61K36/53 , A61K45/06 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。
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38.发明申请公开(公告)号：US20080031982A1
公开(公告)日：2008-02-07
申请号：US11820600
申请日：2007-06-20
申请人： Matthew Tripp , John Babish , Jeffrey Bland , Veera Konda , Amy Hall , Linda Pacioretty , Anu Desai
发明人： Matthew Tripp , John Babish , Jeffrey Bland , Veera Konda , Amy Hall , Linda Pacioretty , Anu Desai
CPC分类号： A61K36/185
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on tetrahydro-isoalpha acids, commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法是基于通常在啤酒花中发现的四氢异亮氨酸。
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39.发明授权公开(公告)号：US07270835B2
公开(公告)日：2007-09-18
申请号：US10689856
申请日：2003-10-20
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary K. Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K36/185 , A61K36/53 , A61K45/06 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
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40.发明授权Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines 有权协同抗炎药物组合物和使用姜黄素或甲基黄嘌呤的相关方法公开(公告)号：US08193201B2
公开(公告)日：2012-06-05
申请号：US13073388
申请日：2011-03-28
IPC分类号： A01N43/90 , A01N31/00 , A61K31/522 , A61K31/45
CPC分类号： A61K31/522 , A61K31/12 , A61K31/19 , A61K36/185 , A61K36/9066 , A61K45/06 , A61K2300/00
摘要： The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
摘要翻译： 本发明提供了含有从啤酒花和甲基黄嘌呤中分离或衍生的级分的组合物。 本发明另外提供了含有源自啤酒花和姜黄素的级分的组合物。 本发明还提供了使用这种组合物减少炎症的方法。
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