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公开(公告)号：US07718198B2
公开(公告)日：2010-05-18
申请号：US11326874
申请日：2006-01-06
申请人： Matthew Tripp , Jeffrey S. Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
发明人： Matthew Tripp , Jeffrey S. Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/12 , A61K36/53 , A61K45/06 , A61K2300/00
摘要： Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
摘要翻译： 公开了还原的异α酸，维生素和矿物质的组合物以及使用其来治疗自身免疫性疾病的方法。 还考虑了包括其它化合物的其它组合。 还公开了利用这种协同作用的协同性质和方法。
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公开(公告)号：US20070166418A1
公开(公告)日：2007-07-19
申请号：US11649584
申请日：2007-01-04
申请人： Matthew Tripp , Jeffrey Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
发明人： Matthew Tripp , Jeffrey Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
IPC分类号： A61K36/185 , A61K31/12
CPC分类号： A61K36/185 , A61K31/12 , A61K33/04 , A61K33/06 , A61K33/24 , A61K33/28 , A61K33/30 , A61K33/34 , A61K45/06 , A61K2300/00
摘要： Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
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公开(公告)号：US20070020352A1
公开(公告)日：2007-01-25
申请号：US11326874
申请日：2006-01-06
申请人： Matthew Tripp , Jeffrey Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
发明人： Matthew Tripp , Jeffrey Bland , Robert Lerman , Amy Hall , Veera Konda , Anu Desai
IPC分类号： A61K36/185 , A61K31/12
CPC分类号： A61K36/185 , A61K31/12 , A61K36/53 , A61K45/06 , A61K2300/00
摘要： Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
摘要翻译： 公开了还原的异α酸，维生素和矿物质的组合物以及使用其来治疗自身免疫性疾病的方法。 还考虑了包括其它化合物的其它组合。 还公开了利用这种协同作用的协同性质和方法。
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4.发明申请XANTHOHUMOL AND TETRAHYDRO-ISOALPHA ACID BASED PROTEIN KINASE MODULATION CANCER TREATMENT 审中-公开甘氨酸和四氢叶酸 - 基于醋酸的蛋白质激酶调控癌症治疗公开(公告)号：US20110021637A1
公开(公告)日：2011-01-27
申请号：US12754820
申请日：2010-04-06
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。
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5.发明授权Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment 失效黄酮和四氢异恶唑酸蛋白激酶调节癌症治疗公开(公告)号：US07736677B2
公开(公告)日：2010-06-15
申请号：US11820568
申请日：2007-06-20
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。
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公开(公告)号：US20090155382A1
公开(公告)日：2009-06-18
申请号：US12030335
申请日：2008-02-13
申请人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
发明人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
CPC分类号： C07D309/24 , A61K31/00 , A61K31/121 , A61K31/122 , A61K31/365 , A61K33/30 , C07C49/255 , C07C49/707 , C07C49/743 , A61K2300/00
摘要： Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
摘要翻译： 描述了用于增强重金属解毒的组合物和方法。 所述的组合物和方法提供了关键解毒系统的增强的活性，包括诱导II期解毒酶，例如谷胱甘肽S-转移酶（GST）和NADPH醌还原酶（NQO1）活性。
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公开(公告)号：US08241674B2
公开(公告)日：2012-08-14
申请号：US12030335
申请日：2008-02-13
申请人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
发明人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
CPC分类号： C07D309/24 , A61K31/00 , A61K31/121 , A61K31/122 , A61K31/365 , A61K33/30 , C07C49/255 , C07C49/707 , C07C49/743 , A61K2300/00
摘要： Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
摘要翻译： 描述了用于增强重金属解毒的组合物和方法。 所述的组合物和方法提供了关键解毒系统的增强的活性，包括诱导II期解毒酶，例如谷胱甘肽S-转移酶（GST）和NADPH醌还原酶（NQO1）活性。
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公开(公告)号：US20120189721A1
公开(公告)日：2012-07-26
申请号：US13352831
申请日：2012-01-18
申请人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
发明人： Matthew L. Tripp , Veera Konda , Amy Hall , Anu Desai , Jeffrey S. Bland
CPC分类号： C07D309/24 , A61K31/00 , A61K31/121 , A61K31/122 , A61K31/365 , A61K33/30 , C07C49/255 , C07C49/707 , C07C49/743 , A61K2300/00
摘要： Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione S-transferases (GSTs), and NADPH quinone reductase (NQO1) activity.
摘要翻译： 描述了用于增强重金属解毒的组合物和方法。 所述的组合物和方法提供了关键解毒系统的增强的活性，包括诱导II期解毒酶，例如谷胱甘肽S-转移酶（GST）和NADPH醌还原酶（NQO1）活性。
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公开(公告)号：US20080051466A1
公开(公告)日：2008-02-28
申请号：US11820607
申请日：2007-06-20
申请人： Matthew Tripp , John Babish , Jeffrey Bland , Veera Konda , Amy Hall , Linda Pacioretty , Anu Desai
发明人： Matthew Tripp , John Babish , Jeffrey Bland , Veera Konda , Amy Hall , Linda Pacioretty , Anu Desai
CPC分类号： A61K31/12
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on isoalpha acids, commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于通常在啤酒花中发现的异α酸。
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10.发明申请Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment 失效黄酮和四氢异恶唑酸蛋白激酶调节癌症治疗公开(公告)号：US20080051465A1
公开(公告)日：2008-02-28
申请号：US11820568
申请日：2007-06-20
申请人： Matthew Tripp , John Babish , Jeffrey Bland , Veera Konda , Amy Hall , Linda Pacioretty , Anu Desai
发明人： Matthew Tripp , John Babish , Jeffrey Bland , Veera Konda , Amy Hall , Linda Pacioretty , Anu Desai
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。
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