公开(公告)号：US10125087B2

公开(公告)日：2018-11-13

申请号：US15747510

申请日：2016-09-14

Applicant: LONZA LTD

Inventor： Christoph Taeschler ,  Ulrich Mayerhoeffer ,  Christophe Girard ,  Michael Bittel ,  Rolf Kalbermatten ,  Claudio Arnold ,  Stefan Garms ,  Christian Schnider ,  Stefan Tille ,  Manuel Favre ,  Guy Raboud ,  Kilian Schnydrig ,  Martin Venetz ,  Thomas Eggel

IPC: C07C201/04 ,  C07C203/00 ,  B01J19/18

Abstract: The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are mixed in a mixing device which provides for a pressure drop of at least 1 bar; the acid is selected from the group consisting of HCI, H2SO4, formic acid, methanesulfonic acid, and mixtures thereof; and the amount of HCI is at least 1.02 molar equivalent based on the molar amount of n-butanol.

公开(公告)号：US09499473B2

公开(公告)日：2016-11-22

申请号：US14389583

申请日：2013-02-27

Applicant: UBE INDUSTRIES, LTD.

Inventor： Syuji Tanaka ,  Hirofumi Il ,  Akira Hino ,  Yuya Fukui ,  Satoshi Ueda

IPC: C07C201/04 ,  C07C68/00 ,  C07C67/36

CPC classification number: C07C201/04 ,  C07C67/36 ,  C07C68/00 ,  C07C69/96 ,  C07C69/36 ,  C07C203/00

Abstract: A method for producing nitrous acid ester in which nitric oxide, oxygen, and an alcohol are reacted, thereby generating nitrous acid ester includes a step of generating nitrous acid ester by supplying a bottom liquid from a bottom part of the reaction column, and nitric oxide and/or carbon monoxide, a step of supplying nitrous acid ester to the reaction column; a step of supplying a reaction liquid containing water, nitric acid, and the alcohol to a nitric acid condensing column from the reactor; and a step of separating a low-boiling point component by distillation from the reaction liquid under control of a concentration of the alcohol in a condensed liquid being generated at a bottom part of the nitric acid condensing column to be less than 4.0% by weight so as to introduce the condensed liquid into the reactor from the nitric acid condensing column.

Abstract translation: 一氧化氮，氧和醇反应生成亚硝酸酯的方法，从而产生亚硝酸酯包括通过从反应塔的底部供应底部液体和一氧化氮产生亚硝酸酯的步骤 和/或一氧化碳，向反应塔供应亚硝酸酯的步骤; 将含有水，硝酸和醇的反应液体从反应器供给到硝酸冷凝塔的步骤; 在硝酸浓缩塔的底部产生的冷凝液中，醇的浓度控制下，通过蒸馏将反应液中的低沸点成分分离成低于4.0重量％的步骤，从而 将浓缩的液体从硝酸冷凝塔引入反应器。

公开(公告)号：US20150105475A1

公开(公告)日：2015-04-16

申请号：US14054194

申请日：2013-10-15

Applicant: Southwest Research Institute

Inventor： Joseph A. McDONOUGH ,  Darrel W. JOHNSTON ,  Paul M. THOMPSON

IPC: C07C201/04 ,  A61M5/19

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The present disclosure relates to devices and methods for the preparation of amyl nitrite formulations at a point of use location from relatively shelf-stable reagents employing acidic cationic exchange resins.

Abstract translation: 本公开涉及在使用酸性阳离子交换树脂的相对稳定的试剂的使用位置制备亚硝酸戊酯制剂的装置和方法。

公开(公告)号：US08722918B2

公开(公告)日：2014-05-13

申请号：US13088253

申请日：2011-04-15

Applicant: Juntao Liu ,  Siqin Li ,  Lei Li ,  Linna Zhang

Inventor： Juntao Liu ,  Siqin Li ,  Lei Li ,  Linna Zhang

IPC: C07C201/04

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The present invention relates to a process for producing C1-C4 alkyl nitrite, comprising loading a resin catalyst layer and/or a porous filler layer into a reactor, passing nitrogen oxide, oxygen and C1-C4 alkanol as raw materials through the resin catalyst layer and/or porous filler layer in a counter current, parallel current or cross current manner, reacting under the conditions including a reaction temperature of from 0 to 150° C., a reaction pressure of from −0.09 to 1.5 MPa, a molar ratio of C1-C4 alkanol/nitrogen oxide of 1-100:1, a molar ratio of nitrogen oxide/oxygen of 4-50:1, to obtain an effluent containing C1-C4 alkyl nitrite, wherein said nitrogen oxide is NO, or a mixed gas containing NO and one or more selected from N2O3 and NO2.

Abstract translation: 本发明涉及一种生产C1-C4烷基亚硝酸盐的方法，包括将树脂催化剂层和/或多孔填料层装入反应器中，使氮氧化物，氧和C1-C4链烷醇作为原料通过树脂催化剂层 和/或多孔填料层，以相对电流，并联电流或交叉电流方式，在0〜150℃的反应温度，-0.09〜1.5MPa的反应压力，-0.09〜1.5MPa的反应压力， C1-C4链烷醇/氮氧化物为1-100:1，氮氧化物/氧摩尔比为4-50:1，得到含有C 1 -C 4烷基亚硝酸盐的流出物，其中所述氮氧化物为NO，或混合 含有NO和选自N 2 O 3和NO 2中的一种或多种的气体。

公开(公告)号：US20070112194A1

公开(公告)日：2007-05-17

申请号：US10522986

申请日：2003-08-06

Applicant: Piero Del Soldato ,  Giancarlo Santus ,  Francesca Benedini

Inventor： Piero Del Soldato ,  Giancarlo Santus ,  Francesca Benedini

IPC: C07D241/04 ,  C07C201/04

CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

Abstract translation: 本发明涉及制备通式（A）化合物的方法，如说明书所述，其中R为药物基团，R 1 -R 12为氢或烷基，m，n，o，q， r和s各自独立地为0〜6的整数，p为0或1，X为O，S，SO，SO 2，NR 13或PR 13或芳基杂芳基，所述方法包括使式 B）R-COOZ（B）其中R如上所定义，Z是氢或选自：Li +，Na +，K +，Ca ++，Mg ++，四烷基铵，四烷基鏻与式（C）化合物的阳离子，如 其描述其中R1-R12和m，n，o，p，q，r，s如上所定义，Y是合适的离去基团。

公开(公告)号：US20050038282A1

公开(公告)日：2005-02-17

申请号：US10946475

申请日：2004-09-21

Applicant: Ryoji Sugise ,  Shuji Tanaka ,  Hirofumi Ii ,  Kazuaki Mii

Inventor： Ryoji Sugise ,  Shuji Tanaka ,  Hirofumi Ii ,  Kazuaki Mii

IPC: C07C201/04 ,  C07C203/00 ,  C07C23/02

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: An alkyl nitrite is produced with high efficiency by bringing a nitrogen monoxide gas into contact with an aqueous solution of an alkyl alcohol and nitric acid in a reactor 2, which aqueous solution may be a liquid fraction generated in an alkyl nitrite-production process in which an alkyl alcohol is reacted with nitrogen monoxide and oxygen in a reaction column 1.

Abstract translation: 通过在反应器2中使一氧化氮气体与烷基醇和硝酸的水溶液接触，可以高效率地生产亚硝酸烷基酯，该水溶液可以是在亚硝酸烷基酯制备方法中产生的液体馏分，其中 在反应塔1中使烷基醇与一氧化氮和氧气反应。

公开(公告)号：US5412147A

公开(公告)日：1995-05-02

申请号：US157779

申请日：1993-11-24

Applicant: Heinz Landscheidt ,  Paul Wagner ,  Alexander Klausener

Inventor： Heinz Landscheidt ,  Paul Wagner ,  Alexander Klausener

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04

Abstract: C.sub.1 -C.sub.6 -Alkyl nitrites can be prepared by reacting nitrogen dioxide with C.sub.1 -C.sub.6 -alcohols, by, in a counterflow-operated column, feeding the alcohol or an alcohol/water mixture into the upper part of the column and the nitrogen dioxide or a nitrogen dioxide/inert gas mixture into the lower part of the column. The resulting alkyl nitrite is removed from the column as the top product and the co-formed nitric acid is removed from the column as the bottom product.

Abstract translation: C 1 -C 6烷基亚硝酸盐可以通过使二氧化氮与C 1 -C 6醇反应来制备，在逆流操作的塔中，将醇或醇/水混合物进料到塔的上部和二氧化氮或 二氧化氮/惰性气体混合物进入塔的下部。 所得到的亚硝酸烷基酯作为顶部产物从塔中除去，共同形成的硝酸作为底部产物从塔中除去。

公开(公告)号：US4487988A

公开(公告)日：1984-12-11

申请号：US489466

申请日：1983-04-28

Applicant: Ian M. Campbell ,  Donald L. Baulch ,  Jonathan M. Chappel

Inventor： Ian M. Campbell ,  Donald L. Baulch ,  Jonathan M. Chappel

IPC: C07C201/02 ,  C07C201/04 ,  C07C201/08 ,  C07C203/00 ,  C07C203/02 ,  C07C205/02 ,  C07C76/02

CPC classification number: C07C201/04 ,  C07C201/02 ,  C07C201/08

Abstract: Organic nitrogen compounds are formed in the vapor phase by organic radical formation by reaction of an organic compound, suitably an alkane, with hydroxyl radicals derived from the reaction between hydrogen peroxide and nitrogen dioxide and the nitration of the organic radicals, suitably with nitrogen dioxide. The process is conducted using a molecular oxygen additive which directs the reaction towards the formation of the nitrate corresponding to the organic compound which may predominate in the organic reaction products.

Abstract translation: 通过有机化合物（合适的是烷烃）与由过氧化氢和二氧化氮之间的反应衍生的羟基自由基以及适当地用二氧化氮硝化有机自由基的有机自由基形成形成有机氮化合物。 该方法使用分子氧添加剂进行，该分子氧添加剂将反应引导形成对应于有机反应产物中可能占优势的有机化合物的硝酸盐。

公开(公告)号：US4353843A

公开(公告)日：1982-10-12

申请号：US239761

申请日：1981-03-12

Applicant: Arthur R. Doumaux, Jr. ,  James M. Downey ,  Joseph P. Henry ,  John M. Hurt

Inventor： Arthur R. Doumaux, Jr. ,  James M. Downey ,  Joseph P. Henry ,  John M. Hurt

IPC: C07C201/04 ,  C07C203/00 ,  C07C77/00

CPC classification number: C07C201/04

Abstract: A vapor phase process for making methyl or ethyl nitrite from methanol or ethanol, respectively, by reacting a nitrogen oxide composition with methanol or ethanol.

Abstract translation: 通过使氮氧化物组合物与甲醇或乙醇反应，分别由甲醇或乙醇制备亚硝酸甲酯或乙酯的气相方法。

公开(公告)号：US4309303A

公开(公告)日：1982-01-05

申请号：US119169

申请日：1980-02-06

Applicant: Walter F. Boyce

Inventor： Walter F. Boyce

IPC: C07C201/04 ,  C07C203/00 ,  C09K15/06 ,  C01B21/50 ,  C07C77/00

CPC classification number: C09K15/06 ,  C07C201/04 ,  Y10S149/118 ,  Y10S149/119

Abstract: This invention relates to a method of stabilizing liquid alkyl nitrites by adding ethyl hydroxyethyl cellulose, calcium silicate and mixtures thereof and mixing to produce solid state compositions and to stabilized compositions thereof.

Abstract translation: 本发明涉及通过加入乙基羟乙基纤维素，硅酸钙及其混合物来稳定液体烷基亚硝酸盐的方法，并混合以产生固态组合物及其稳定组合物。