公开(公告)号：USPP20515P3

公开(公告)日：2009-12-01

申请号：US12072773

申请日：2008-02-28

申请人： Narandra Patel

发明人： Narandra Patel

IPC分类号： A01H5/00

CPC分类号： A01H5/08

摘要： A new and distinct rabbiteye blueberry variety is described. The variety results from selection among a population of seedlings derived from crossing the blueberry varieties known as ‘Centurion’ (not patented) and ‘Rahi’ (not patented). The fruit of this new variety has an attractive appearance characterised by outstanding fruit quality with a good bloom and little grittiness, and an exceptionally late fruiting season. The new variety appears suitable for the late fresh fruit market and has been named ‘Centra Blue’.

摘要翻译： 描述了一种新的和独特的兔子蓝莓品种。 来自跨越被称为“Centurion”（未获专利）的蓝莓品种和“Rahi”（未获得专利）的幼苗种群的选择的品种结果。 这种新品种的果实具有吸引人的外观，其特征是优良的水果品质，绽放和小巧的花朵，以及非常晚的果实季节。 新品种适合晚期新鲜水果市场，并被命名为“Centra Blue”。

公开(公告)号：US07592008B2

公开(公告)日：2009-09-22

申请号：US11033489

申请日：2005-01-11

申请人： Stephen G. Sligar ,  Timothy H. Bayburt ,  Mary A. Schuler ,  Natanya R. Civjan ,  Ylena V. Grinkova ,  Ilia G. Denisov ,  Stephen James Grimme

发明人： Stephen G. Sligar ,  Timothy H. Bayburt ,  Mary A. Schuler ,  Natanya R. Civjan ,  Ylena V. Grinkova ,  Ilia G. Denisov ,  Stephen James Grimme

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K39/12 ,  A61K39/02 ,  A61K39/002

CPC分类号： C07K14/775 ,  C07K14/47

摘要： The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.

摘要翻译： 本发明的膜支架蛋白（MSP）与疏水或部分疏水的蛋白质组合形成可溶性纳米级颗粒，其保留天然结构和功能; 在稳定性和保存生物活性和天然构象方面，它们比脂质体和洗涤剂胶束得到改善。 在磷脂的存在下，MSP形成纳米视磷脂双层盘，MSP在双层结构域的周边稳定颗粒。 颗粒双层结构允许在溶液中或固体载体上操作掺入的蛋白质，包括用于诸如扫描探针显微镜或表面等离子体共振的表面敏感技术。 在完整性和维持结合蛋白质的生物活性方面坚固的纳米级颗粒有助于药物和生物学研究，结构/功能相关性，结构测定，生物分离和药物发现。

公开(公告)号：US07560107B2

公开(公告)日：2009-07-14

申请号：US11550366

申请日：2006-10-17

申请人： John S. Lollar

发明人： John S. Lollar

IPC分类号： C12N9/64 ,  C12N15/00 ,  C12P21/00 ,  A61K38/48

CPC分类号： A61K38/37 ,  A61K9/0019 ,  A61K48/00 ,  C07K14/755 ,  C07K2319/00

摘要： Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of hemophiliacs, especially those undergoing bleeding episodes.

摘要翻译： 公开了修饰的猪因子VIII，其中大多数B结构域已经通过遗传工程被去除。 该修饰因子VIII特别适用于治疗血友病患者，特别是那些发生流血事件的患者。

公开(公告)号：US07426938B2

公开(公告)日：2008-09-23

申请号：US11334047

申请日：2006-01-18

申请人： Larry J. Bohaychuk ,  Loren Kowalchuk ,  Patrick Rabby ,  Chad Dannish

发明人： Larry J. Bohaychuk ,  Loren Kowalchuk ,  Patrick Rabby ,  Chad Dannish

IPC分类号： F16K3/24 ,  F16K47/14

CPC分类号： F16K47/08 ,  E21B34/02 ,  F16K3/24 ,  Y10T137/86759

摘要： A choke valve having flow trim components, namely a tubular cage and a flow collar or plug, and related components, designed and arranged for reduced fracturing. The invention includes a protective tubular sleeve, or insert cartridge in which the side ports are located to overlap with the intersection of axes of the inlet and outlet bores, but to avoid direct impingement of fluid along the axis of the inlet bore. In the cage, at least a pair of main flow ports are located to overlap with the intersection of the axes of the inlet and outlet bores, and are aligned with the side ports of the tubular sleeve or cartridge to communicate directly with the side ports. In this manner fluid may enter the choke valve through the inlet bore and pass through the main flow ports at reduced pressure and continue out through the outlet bore, without direct impingement on the side wall of the flow trim components.

摘要翻译： 具有流动装配部件的节流阀，即管状保持架和流动套管或塞子以及相关部件，其设计和布置用于减少压裂。 本发明包括保护性管状套筒或插入料筒，其中侧面端口被定位成与入口孔和出口孔的轴线重叠，但是避免流体沿着入口孔的轴线的直接冲击。 在保持架中，至少一对主流体端口被定位成与入口孔和出口孔的轴线交叉重叠，并且与管状套管或筒的侧端口对齐，以与侧端口直接连通。 以这种方式，流体可以通过入口孔进入阻风阀，并以减压的方式穿过主流量端口，并且通过出口孔继续流出，而不会直接冲击在流动装配部件的侧壁上。

公开(公告)号：US07393696B2

公开(公告)日：2008-07-01

申请号：US10255162

申请日：2002-09-24

申请人： Jay W. Roth ,  Mark Colgin ,  Roger Hurst ,  Diane Newman ,  Cathy Landmann

发明人： Jay W. Roth ,  Mark Colgin ,  Roger Hurst ,  Diane Newman ,  Cathy Landmann

IPC分类号： G01N33/53

CPC分类号： A61D17/006 ,  G01N2800/368

摘要： This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and/or ungulate animals. Antigens from Group A (early pregnancy antigens), and/or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field.

摘要翻译： 本发明提供了牛妊娠试验方法和装置。 该试验也适用于其他反刍动物和/或有蹄类动物。 在来自动物的流体中检测到来自A组的早期抗原（早期怀孕抗原）和/或B组（妊娠中期抗原）和C组（早，中，晚期妊娠抗原），并且可靠地确定妊娠。 本发明的妊娠测定优选使用在现场提供即时结果的免疫测定装置来进行。

公开(公告)号：US07392903B2

公开(公告)日：2008-07-01

申请号：US10992630

申请日：2004-11-18

申请人： Scott Jolley ,  Chris Jolley

发明人： Scott Jolley ,  Chris Jolley

IPC分类号： B65D83/10

CPC分类号： A61B50/362 ,  A61B2050/006 ,  A61B2050/0076 ,  A61B2050/0083 ,  Y10S206/822

摘要： A disposal device used for the disposal of hazardous contaminated sharps, such as hypodermic needles, generated from treating patients. The disposal device is compact enough to fit in medical kits and hospital trays and is able to be used at the patient's bedside, thus eliminating the need to recap or transport contaminated sharps to non-bedside sharp disposal devices. The shape of the device provides enough stability to prevent the device from tipping over if bumped.

摘要翻译： 用于处理患者产生的有害污染的尖锐物（如皮下注射针）的处置装置。 处理设备足够紧凑，可以安装在医疗箱和医院托盘中，并且能够在患者的床边使用，因此不需要将污染的尖锐物重新吸收或运输到非床边的尖锐处理设备。 该装置的形状提供了足够的稳定性，以防止装置翻倒，如果碰撞。

公开(公告)号：US07312323B2

公开(公告)日：2007-12-25

申请号：US10540759

申请日：2003-12-24

申请人： Sol Green ,  Ellen Friel ,  Lesley Beuning ,  Elspeth Macrae ,  Adam Matich

发明人： Sol Green ,  Ellen Friel ,  Lesley Beuning ,  Elspeth Macrae ,  Adam Matich

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N9/00 ,  C12N15/29

CPC分类号： C12N9/1085 ,  C07H21/04 ,  C12N15/8243

摘要： The invention relates to a multifunctional germacrene-D synthase and a polynucleotide encoding it. Included also are genetic constructs, transgenic organisms, plant selection methods and biofermentation methods. The enzyme may be used to prepare germacrene-D and/or other sesquiterpenes such as germacrene-D, delta-cadinene, gamma-cadinene, gamma-muurolene, gamma-elemene, delta-elemene, elemol or germacrene-B.

摘要翻译： 本发明涉及多功能germacrene-D合成酶和编码它的多核苷酸。 还包括遗传构建体，转基因生物，植物选择方法和生物发酵方法。 该酶可用于制备germacrene-D和/或其它倍半萜，例如germacrene-D，δ-卡汀，γ-卡丁烯，γ-鲁鲁烯，γ-榄香烯，δ-榄香烯，elemol或germacrene-B。

公开(公告)号：US07309817B2

公开(公告)日：2007-12-18

申请号：US10531357

申请日：2003-10-15

申请人： Sol Alexander Green ,  Ellen Nicola Friel ,  Lesley Leah Beuning ,  Elspeth Ann Macrae

发明人： Sol Alexander Green ,  Ellen Nicola Friel ,  Lesley Leah Beuning ,  Elspeth Ann Macrae

IPC分类号： A01H1/00 ,  C07H21/04 ,  C12N15/29 ,  C12N15/52 ,  C07K14/415

CPC分类号： C12N15/8243 ,  C12N9/88

摘要： The present invention provides an isolated alpha-farnesene synthase and polynucleotide sequences encoding the enzyme. The invention also provides nucleic acid constructs, vectors and host cells incorporating the polynucleotide sequences. It further relates to the production of alpha-farnesene using the enzyme and modulation of alpha-farnesene synthesis in plants and selection of plants with altered alpha-farnesene synthase activity.

摘要翻译： 本发明提供了分离的α-法呢烯合酶和编码该酶的多核苷酸序列。 本发明还提供了掺入多核苷酸序列的核酸构建体，载体和宿主细胞。 它还涉及使用酶的α-法呢烯的生产和植物中α-法呢烯合成的调节以及具有改变的α-法呢烯合酶活性的植物的选择。

公开(公告)号：US07306201B2

公开(公告)日：2007-12-11

申请号：US11205751

申请日：2005-08-17

申请人： Tony M. Lam

发明人： Tony M. Lam

IPC分类号： F16K25/00

CPC分类号： F16K3/0227

摘要： A gate valve for controlling fluid flow, in which a valve body forms a cylindrical flowbore and includes a gate cavity intersecting the flowbore to provide opposed openings into the flowbore. Seat pockets are formed in the opposed openings, each with a radial base and a side wall, and may optionally include metal carrier ring sealed in the seat pockets. The gate is slidably movable within the valve body between open and closed positions. Annular seat elements are mounted in each seat pocket for limited axial movement on opposite sides of the gate, with a first seal surface for sealing against the seat pocket or optional carrier ring, and a second seal surface for sealing against the gate. A non-metallic bridging seal formed as a face seal is provided between the first seal surface of the annular seat element and the seat pocket (or optional carrier ring). The bridging seal is adapted to bridge any gap formed at the first seal surface of the annular seat element such that sealing engagement is maintained across the gap at all times as the gate moves between open and closed positions, while still permitting the limited axial movement of the annular seat element. Preferred embodiments of the bridging seal include tongue and groove seals and bridge ring inserts. A second seal to the seat pocket is also preferred.

摘要翻译： 一种用于控制流体流动的闸阀，其中阀体形成圆柱形流孔并且包括与流孔相交的浇口腔，以将相对的开口提供到钻孔中。 座袋形成在相对的开口中，每个具有径向基部和侧壁，并且可以可选地包括密封在座袋中的金属载体环。 闸门可在阀体内在打开位置和关闭位置之间滑动。 环形座元件安装在每个座椅口袋中，用于在门的相对侧上有限的轴向运动，具有用于密封座椅口袋或可选承载环的第一密封表面，以及用于密封抵靠门的第二密封表面。 形成为面密封件的非金属桥接密封件设置在环形座元件的第一密封表面和座袋（或可选的承载环）之间。 桥接密封件适于桥接形成在环形座元件的第一密封表面处的任何间隙，使得当门在打开和关闭位置之间移动时始终在间隙上保持密封接合，同时仍允许有限的轴向移动 环形座元件。 桥接密封件的优选实施例包括舌和槽密封件和桥环插入件。 对座椅口袋的第二密封也是优选的。

公开(公告)号：US07285386B2

公开(公告)日：2007-10-23

申请号：US10978239

申请日：2004-10-29

申请人： Michelle A. Ozbun

发明人： Michelle A. Ozbun

IPC分类号： C12Q1/68

CPC分类号： A01K67/027 ,  A01K2227/106 ,  A01K2267/0331 ,  A01K2267/0337 ,  C12N2710/20011

摘要： Provided is an animal model system for the study of papillomaviruses, especially anogenital papillomaviruses, especially those causing anogenital and/or head and neck cancers. The Rhesus papillomavirus (especially RhPV1) is a useful model for human papillomaviruses which cause anogenital infections and cancers of the anogenital region and/or the head, neck and respiratory system.

摘要翻译： 提供了一种用于研究乳头状瘤病毒，特别是肛门生殖器乳头瘤病毒的动物模型系统，特别是那些引起肛门生殖和/或头颈部癌症的哺乳动物模型系统。 恒河猴乳头瘤病毒（特别是RhPV1）是人乳头状瘤病毒的有用模型，其导致肛门生殖器感染和肛门生殖区域和/或头颈部和呼吸系统的癌症。