公开(公告)号：US20220100985A1

公开(公告)日：2022-03-31

申请号：US17427086

申请日：2020-05-08

Applicant: Academia Sinica

Inventor： Yi-Sheng WANG ,  Chih-Hao HSIAO

IPC: G06K9/00

Abstract: Disclosed herein are methods and apparatus for reducing errors in spectroscopic measurements. The present method minimizes errors by aligning peak positions and recalculating intensities in every single-scan spectrum with reference to spectral features observed in the spectrum integrating all uncorrected single-scan spectra. Additionally, the corrected single-scan spectra are integrated to improve the resolving power, signal intensity and peak shape.

公开(公告)号：US20220090023A1

公开(公告)日：2022-03-24

申请号：US17418619

申请日：2019-12-26

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Wei-Ju CHEN

IPC: C12N5/074 ,  C12N5/00 ,  C12N15/86 ,  C12N15/873 ,  C12N15/85 ,  C07K14/435

Abstract: The present invention relates to a method for regulating potency of pluripotent stem cells (PSCs) by modulating expression of podocalyxin-like protein 1 (PODXL) and applications thereof.

公开(公告)号：US11264601B2

公开(公告)日：2022-03-01

申请号：US16189005

申请日：2018-11-13

Applicant: National Chi Nan University ,  Academia Sinica

Inventor： Horng-Yi Tang ,  Maw-Kuen Wu ,  Yan-Ting Chen ,  Prem Chandan Devanga

IPC: H01M4/04 ,  H01M10/0525 ,  H01M4/485

Abstract: A method for making a vanadium pentoxide-based active material for a cathode of an alkali metal ion battery includes steps of: a) preparing an aqueous solution of a triazine derivative of Formula (I) wherein each R independently represents hydrogen or an amino group; and b) adding vanadium pentoxide to the aqueous solution of the triazine derivative under stirring, so as to permit condensation among hydrolyzed vanadium pentoxide along with self-assembly of the triazine derivatives to obtain a reaction solution containing the active material.

公开(公告)号：US20210361706A1

公开(公告)日：2021-11-25

申请号：US17269612

申请日：2019-08-28

Applicant: ACADEMIA SINICA

Inventor： Nan-Shih LIAO ,  Shih-Wen HUANG ,  Zhen-Qi WU ,  Yein-Gei LAI ,  Yae-Huei LIOU

IPC: A61K35/17 ,  A61K31/675 ,  A61P35/00

Abstract: Combined therapy of cancer (e.g., breast cancer) involving a cyclophosphamide compound and natural killer (NK) cells. Also provided herein are methods for inducing immune memory and/or reducing the risk of tumor recurrence using the combined therapy of a cyclophosphamide compound and NK cells.

公开(公告)号：US20210315966A1

公开(公告)日：2021-10-14

申请号：US17265090

申请日：2019-07-30

Applicant: Academia Sinica

Inventor： Che-Ming Jack Hu ,  Yu-Han Liu ,  Te-Li Chen

IPC: A61K38/12 ,  A61K9/16 ,  A61P31/04

Abstract: A therapeutic nanoparticle containing a cationic polypeptide and a polyanionic molecule, in which the cationic polypeptide, exerting antibacterial activity, forms electrostatic interaction with the polyanionic molecule, and the therapeutic nanoparticle has a diameter of less than 50 nm. Also disclosed are a pharmaceutical composition, a treatment method, and a preparation method, all related to the therapeutic nanoparticle.

公开(公告)号：US20210292438A1

公开(公告)日：2021-09-23

申请号：US17340102

申请日：2021-06-07

Applicant: ACADEMIA SINICA

Inventor： Steve ROFFLER ,  Tian-Lu Cheng ,  Yu-Cheng Su ,  Kuo-Hsiang Chuang

IPC: C07K16/44 ,  A61K47/60 ,  A61K47/69 ,  A61P35/00 ,  A61K31/55 ,  A61K31/704 ,  A61K51/06 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  G01N33/574

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also disclosed is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. Further disclosed is a method for diagnosing a cell-mediated disorder by administering a PEG engager followed by a PEGylated diagnostic agent.

公开(公告)号：US11119078B2

公开(公告)日：2021-09-14

申请号：US16412704

申请日：2019-05-15

Applicant: ACADEMIA SINICA

Inventor： Chung-Hsuan Chen ,  Chen-Yu Hsieh ,  Jung-Lee Lin

IPC: G01N30/74 ,  G01N30/02 ,  G01N21/33

Abstract: Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.

公开(公告)号：US11103567B2

公开(公告)日：2021-08-31

申请号：US16442334

申请日：2019-06-14

Applicant: Academia Sinica

Inventor： Shih-Hsiung Wu ,  Chung-Yi Wu ,  I-Ming Lee ,  Feng-Ling Yang

IPC: A61K39/05 ,  A61K45/06 ,  A61P31/04 ,  A61K39/00

Abstract: Disclosed herein is a glycoconjugate vaccine conferring protection against a Gram negative pathogen infection, a method of manufacturing the glycoconjugate vaccine, and use of the glycoconjugate vaccine for treating bacterial infection. The glycoconjugate vaccine of the present disclosure has the structure of formula (I), wherein, L is a maleimide-type linker, which is connected to the carrier protein via a maleimide bond formed therebetween; and n and m are independently an integral or a non-integral number between 2 and 20.

公开(公告)号：US11086051B2

公开(公告)日：2021-08-10

申请号：US15599943

申请日：2017-05-19

Applicant: Academia Sinica

Inventor： Din-Ping Tsai ,  Pin-Chieh Wu

IPC: G02B5/00 ,  G02B1/00 ,  G03H1/02 ,  G03H1/08

Abstract: The present invention provides an optical component comprising a dielectric layer and a nanorod array; the nanorod array is formed on a surface of the dielectric layer and extends along a lateral direction and a vertical direction. The nanorod array comprises a plurality of nanorods extending along the dielectric layer. The nanorods have a gap between one another, and an angle is defined by two adjacent nanorods. A bump is formed at each of two ends of the nanorod.

公开(公告)号：US20210236647A1

公开(公告)日：2021-08-05

申请号：US16062274

申请日：2017-01-11

Applicant: Academia Sinica

Inventor： Han-Chung WU ,  Chen-Yun YEH

IPC: A61K47/62 ,  A61K47/69 ,  A61K9/127 ,  A61P35/00 ,  A61K49/00 ,  A61K49/18

Abstract: An isolated or a synthetic targeting peptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 8 is disclosed. The targeting peptide may be conjugated to a component selected from the group consisting of polymeric micelles, lipoprotein-based drug carriers, nanoparticle drug carriers, a chemotherapeutic agent, a micelle, a liposome, dendrimers, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a prostate cancer cell, a stem cell, and an imaging agent. Also disclosed are a kit for imaging and detecting the presence of prostate cancer cells in vivo or in vitro, and a composition for treating prostate cancer, inhibiting prostate cancer cell growth, inducing prostate cancer cell cytotoxicity, and/or increasing the survival rate in a prostate cancer patient.