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    Device for characterizing particles and uses thereof
    3.
    发明授权
    Device for characterizing particles and uses thereof 有权

    公开(公告)号：US10998175B2

    公开(公告)日：2021-05-04

    申请号：US16686203

    申请日：2019-11-17

    Applicant: Academia Sinica

    Inventor： Abdil Ozdemir ,  Jung-Lee Lin ,  Chung-Hsuan Chen

    IPC: H01J49/00 ,  H01J49/16 ,  H01J49/06

    Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.

    NANOPARTICLE-ASSISTED ULTRASOUND FOR CANCER THERAPY
    5.
    发明申请
    NANOPARTICLE-ASSISTED ULTRASOUND FOR CANCER THERAPY 有权
    用于癌症治疗的纳米辅助超声波治疗

    公开(公告)号：US20140335156A1

    公开(公告)日：2014-11-13

    申请号：US14253977

    申请日：2014-04-16

    Applicant: Academia Sinica

    Inventor： Olga K. Kosheleva ,  Peter Lai ,  Nelson G. Chen ,  Michael Hsiao ,  Chung-Hsuan Chen

    IPC: A61K9/00

    CPC classification number: A61K41/0033 ,  A61K41/0028 ,  A61K47/6923 ,  A61N7/00 ,  A61N7/02 ,  Y10S977/773 ,  Y10S977/911

    Abstract: Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, PEG, or liposome nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.

    Abstract translation: 通过将细胞暴露于纳米颗粒并用聚焦的低至中等功率超声照射来杀死受试者的癌细胞和治疗癌症的方法。 纳米颗粒可以是金，氧化铁，铜，银，聚苯乙烯，PEG或脂质体纳米颗粒。 纳米颗粒可以具有连接的癌症药物，例如基于抗体的癌症药物。

    Pulsed ion beam source for electrospray mass spectrometry
    6.
    发明授权
    Pulsed ion beam source for electrospray mass spectrometry 有权
    用于电喷雾质谱的脉冲离子束源

    公开(公告)号：US09524859B2

    公开(公告)日：2016-12-20

    申请号：US14450267

    申请日：2014-08-03

    Applicant: Academia Sinica

    Inventor： Jung-Lee Lin ,  Chung-Hsuan Chen ,  Chen-Yu Hsieh

    IPC: H01J49/16 ,  H01J49/04

    CPC classification number: H01J49/165 ,  H01J49/0495

    Abstract: Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry.

    Abstract translation: 用于产生脉冲离子束的装置和方法。 脉冲离子束可用于进行质谱分析。 脉冲电磁阀可以在预真空室中提供来自电喷雾的脉冲离子束。 脉冲离子束可以进入高真空区域，质谱仪可以进行质谱分析。

    Automatic amino acid sequencing of glycopeptide by Y1 ions
    7.
    发明授权
    Automatic amino acid sequencing of glycopeptide by Y1 ions 有权
    通过Y1离子自动氨基酸测序糖肽

    公开(公告)号：US09484193B2

    公开(公告)日：2016-11-01

    申请号：US14298911

    申请日：2014-06-07

    Applicant: Academia Sinica

    Inventor： Chung-Hsuan Chen ,  Chein-Hung Chen ,  Hsin Yu Hsieh ,  Pang-Hung Hsu ,  Jung-Lee Lin

    IPC: H01J49/00 ,  G01N33/68

    CPC classification number: H01J49/0031 ,  G01N33/6818 ,  G01N33/6851 ,  H01J49/0054

    Abstract: Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide.

    Abstract translation: 通过质谱法对糖肽进行自动氨基酸测序的装置和方法。 糖肽通过较高的能量碰撞解离断裂而碎裂，并通过碰撞诱导的解离片段依次碎裂。 分离糖肽Y1离子，碎片糖肽Y1离子的质谱提供对应于糖肽的氨基酸序列的质谱峰。

    HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH UV-VISIBLE DETECTION
    9.
    发明申请
    HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH UV-VISIBLE DETECTION 审中-公开
    高性能液相色谱与紫外可见检测

    公开(公告)号：US20150143880A1

    公开(公告)日：2015-05-28

    申请号：US14551050

    申请日：2014-11-23

    Applicant: Academia Sinica

    Inventor： Chung-Hsuan Chen ,  Chen-Yu Hsieh ,  Jung-Lee Lin

    IPC: G01N30/74

    CPC classification number: G01N30/74 ,  G01N21/33

    Abstract: Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.

    Abstract translation: 高效液相色谱仪的设备和方法。 该装置包括一个包括两个线性步进泵的制备回路，一个样品回路，包括一个样品注射器，一个色谱柱和一个检测器装置。 检测器装置可以包括闪光灯，流动池和包括入口狭缝，光栅的光传感器; 和电荷耦合器件阵列。

    PULSED ION BEAM SOURCE FOR ELECTROSPRAY MASS SPECTROMETRY
    10.
    发明申请
    PULSED ION BEAM SOURCE FOR ELECTROSPRAY MASS SPECTROMETRY 有权
    用于电泳质谱分析的脉冲离子束源

    公开(公告)号：US20150136973A1

    公开(公告)日：2015-05-21

    申请号：US14450267

    申请日：2014-08-03

    Applicant: Academia Sinica

    Inventor： Jung-Lee Lin ,  Chung-Hsuan Chen ,  Chen-Yu Hsieh

    IPC: H01J49/16 ,  H01J49/26 ,  H01J49/00 ,  H01J49/24

    CPC classification number: H01J49/165 ,  H01J49/0495

    Abstract: Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry.

    Abstract translation: 用于产生脉冲离子束的装置和方法。 脉冲离子束可用于进行质谱分析。 脉冲电磁阀可以在预真空室中提供来自电喷雾的脉冲离子束。 脉冲离子束可以进入高真空区域，质谱仪可以进行质谱分析。

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