公开(公告)号：US06361522B1

公开(公告)日：2002-03-26

申请号：US09422433

申请日：1999-10-21

Applicant: Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

Inventor： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

IPC: A61M3100

CPC classification number: A61N1/30 ,  A61N1/3621 ,  Y10S128/12 ,  Y10S128/13

Abstract: A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

公开(公告)号：US06321122B1

公开(公告)日：2001-11-20

申请号：US09121018

申请日：1998-07-22

Applicant: Avram Scheiner ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  John E. Heil ,  William Hsu ,  Ronald W. Heil, Jr.

Inventor： Avram Scheiner ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  John E. Heil ,  William Hsu ,  Ronald W. Heil, Jr.

IPC: A61N100

CPC classification number: A61N1/0573

Abstract: A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.

Abstract translation: 适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。 引线包括具有第一导电表面的第一远端电极。 引线体还具有具有第二导电表面的第二电极。 第二电极适于定位并固定在心脏心房的壁上。 被动固定元件可以用作第二电极的一部分。 引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

公开(公告)号：US5466247A

公开(公告)日：1995-11-14

申请号：US140815

申请日：1993-10-21

Applicant: Avram Scheiner ,  Ernest B. Marsolais

Inventor： Avram Scheiner ,  Ernest B. Marsolais

IPC: A61N1/05 ,  A61N1/04

CPC classification number: A61N1/05

Abstract: A subcutaneously implantable device is provided for either electrically stimulating skeletal musculature or sensing electrical potential at its surface without directly contacting the musculature. The implantable device comprises an electrode constructed from a single generally planar sheet of electrically conductive material and having a first surface adapted to face the skeletal musculature and an opposite surface adapted to face away from the skeletal musculature. A flexible casing covers at least a substantial portion of the opposite surface of the electrically conductive sheet. At least one electrical lead is attached at one end to the electrically conductive sheet and is attachable at an opposite end to an electrical current source. The generally planar electrically conductive sheet is preferably comprised of a noble metal, such as platinum, and has a surface area sufficiently large to distribute the charge required to stimulate the targeted muscle. The electrical leads are preferably constructed from lengths of stranded stainless steel wire which are coiled in helical fashion to increase their capacity for elongation.

Abstract translation: 提供皮下植入装置用于电刺激骨骼肌肉组织或感测其表面的电位而不直接接触肌肉组织。 可植入装置包括由单一的大致平面的导电材料片构成的电极，并且具有适于面对骨骼肌肉的第一表面和适合于远离骨骼肌肉组织的相对表面。 柔性套管覆盖导电片的相对表面的至少大部分。 至少一个电引线在一端连接到导电片，并且可以在与电流源相对的端部附接。 通常平面的导电片优选由贵金属（例如铂）组成，并且具有足够大的表面积以分配刺激目标肌肉所需的电荷。 电引线优选地由长度为绞合的不锈钢丝构成，其以螺旋方式卷绕以增加其延伸能力。

公开(公告)号：US09370654B2

公开(公告)日：2016-06-21

申请号：US12360680

申请日：2009-01-27

Applicant: Avram Scheiner ,  David E. Euler

Inventor： Avram Scheiner ,  David E. Euler

IPC: A61N1/05 ,  A61N1/36 ,  A61B5/00

CPC classification number: A61N1/0556 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/7217 ,  A61N1/36114

Abstract: An implantable medical device and associated method deliver a therapy to an autonomic nerve. The therapy delivery includes delivering therapeutic low frequency (LF) electrical stimulation pulses to the autonomic nerve and delivering a high frequency electrical signal to the autonomic nerve during the LF frequency stimulation pulse delivery. The high frequency stimulation signal blocks activation of autonomic nerve fibers innervating a non-targeted tissue during the therapeutic LF stimulation pulse delivery.

Abstract translation: 可植入医疗装置和相关方法将治疗递送至自主神经。 治疗递送包括在LF频率刺激脉冲传送期间向自主神经递送治疗性低频（LF）电刺激脉冲并将高频电信号传送到自主神经。 高频刺激信号阻止在治疗性LF刺激脉冲输送期间支配非目标组织的自主神经纤维的活化。

公开(公告)号：US08527045B2

公开(公告)日：2013-09-03

申请号：US12610149

申请日：2009-10-30

Applicant: Paul G. Krause ,  Avram Scheiner

Inventor： Paul G. Krause ,  Avram Scheiner

IPC: A61N1/362

CPC classification number: A61N1/36114 ,  A61N1/36514 ,  A61N1/36521

Abstract: An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.

公开(公告)号：US08515535B2

公开(公告)日：2013-08-20

申请号：US12695895

申请日：2010-01-28

Applicant: Donald L. Hopper ,  John M. Voegele ,  Jesse W. Hartley ,  Avram Scheiner

Inventor： Donald L. Hopper ,  John M. Voegele ,  Jesse W. Hartley ,  Avram Scheiner

IPC: A61N1/00

CPC classification number: A61B5/686 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/076 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/085 ,  A61B5/091 ,  A61B5/1118 ,  A61B5/4836 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  A61B5/747 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/3987 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

Abstract: Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.

公开(公告)号：US20130073000A1

公开(公告)日：2013-03-21

申请号：US13678048

申请日：2012-11-15

Applicant: Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

Inventor： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

IPC: A61N1/36 ,  A61N1/378

CPC classification number: A61N1/36117 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37288 ,  A61N1/3787

Abstract: One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

Abstract translation: 本主题的一个方面涉及可植入医疗装置。 该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。 神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。 控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。 本文提供了其他方面。

公开(公告)号：US20130030488A1

公开(公告)日：2013-01-31

申请号：US13192914

申请日：2011-07-28

Applicant: Yong K. Cho ,  Shaileshkumar Musley ,  Avram Scheiner

Inventor： Yong K. Cho ,  Shaileshkumar Musley ,  Avram Scheiner

IPC: A61N1/36 ,  A61N1/365

CPC classification number: A61N1/3655 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36521

Abstract: Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.

公开(公告)号：US08301234B2

公开(公告)日：2012-10-30

申请号：US13288105

申请日：2011-11-03

Applicant: Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

Inventor： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC: A61B5/04

CPC classification number: A61B5/0402 ,  A61N1/365 ,  A61N1/3756

Abstract: An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

Abstract translation: 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20120239099A1

公开(公告)日：2012-09-20

申请号：US13484060

申请日：2012-05-30

Applicant: Ronald W. Heil, JR. ,  Avram Scheiner ,  Imad Libbus

Inventor： Ronald W. Heil, JR. ,  Avram Scheiner ,  Imad Libbus

IPC: A61N1/365 ,  A61N1/39 ,  A61N1/362

CPC classification number: A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

Abstract: Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

Abstract translation: 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。