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    REDUNDANT TRACES FOR FLEXIBLE CIRCUITS USED IN AN ENERGY DELIVERY DEVICE
    41.
    发明申请
    REDUNDANT TRACES FOR FLEXIBLE CIRCUITS USED IN AN ENERGY DELIVERY DEVICE 有权

    公开(公告)号：US20220219005A1

    公开(公告)日：2022-07-14

    申请号：US17590027

    申请日：2022-02-01

    申请人： BAUSCH HEALTH IRELAND LIMITED

    发明人： Craig Collins ,  Kurt Duclos ,  Martin Kenney

    IPC分类号： A61N1/40 ,  H05K1/18 ,  G01K7/24 ,  H05K1/02

    摘要： Energy delivery devices with a flexible circuit. The energy delivery devices may be used in the treatment of human tissue, and the flexible circuit move or flex during use. The flexible circuit may include an electronic component and a trace connected with the electronic component. The trace may have a plurality of sections that provide parallel current paths over a portion of the trace. Alternatively, the flexible circuit may include a plurality of traces that are connected with the terminal of the electronic component to provide parallel current paths over their entire length to the terminal of the electronic component. These redundant parallel current paths improve device reliability.

    Guanylate Cyclase Receptor Agonists For The Treatment Of Tissue Inflammation And Carcinogenesis
    48.
    发明申请
    Guanylate Cyclase Receptor Agonists For The Treatment Of Tissue Inflammation And Carcinogenesis 审中-公开

    公开(公告)号：US20200325176A1

    公开(公告)日：2020-10-15

    申请号：US16870942

    申请日：2020-05-09

    申请人： Bausch Health Ireland Limited

    发明人： Kunwar Shailubhai ,  Gregory Nikiforovich ,  Gary S. Jacob

    IPC分类号： C07K7/64 ,  A61K45/06 ,  C07K7/08 ,  A61K47/60 ,  A61P29/00 ,  A61K38/10 ,  A61K38/12 ,  C07K7/50

    摘要： A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular production of cGMP. The at least one peptide agonist of a guanylate cyclase receptor may be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The inhibitor may be a small molecule, peptide, protein or other compound that inhibits the degradation of cGMP. Without requiring a particular mechanism of action, this treatment may restore a healthy balance between proliferation and apoptosis in the subject's population of epithelial cells, and also suppress carcinogenesis. Thus, the method may be used to treat, inter alia, inflammation, including gastrointestinal inflammatory disorders, general organ inflammation and asthma, and carcinogenesis of the lung, gastrointestinal tract, bladder, testis, prostate and pancreas, or polyps.

    PAIN MITIGATION BY MECHANICAL STIMULATION WHEN TREATING TISSUE WITH ELECTROMAGNETIC ENERGY
    49.
    发明申请
    PAIN MITIGATION BY MECHANICAL STIMULATION WHEN TREATING TISSUE WITH ELECTROMAGNETIC ENERGY 审中-公开

    公开(公告)号：US20200069356A1

    公开(公告)日：2020-03-05

    申请号：US16556664

    申请日：2019-08-30

    申请人： BAUSCH HEALTH IRELAND LIMITED

    发明人： Craig Robert Bockenstedt ,  Gregory T. Wing

    IPC分类号： A61B18/12 ,  A61B18/18

    摘要： Apparatus and methods for delivering electromagnetic energy to a patient's tissue and reducing pain experienced by the patient during treatment of the patient's tissue with the delivered electromagnetic energy. The tissue treatment apparatus includes a delivery device configured to transfer the electromagnetic energy through the skin surface to a region of tissue, and also includes a vibration device that is mechanically coupled with the delivery device. The vibration device is configured to transfer mechanical vibrations along an axis substantially normal to the skin surface to the region of tissue being treated.