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公开(公告)号：US20200306258A1
公开(公告)日：2020-10-01
申请号：US16834061
申请日：2020-03-30
发明人： Arrigo DeBENEDETTI , Siddhant BHOIR , Vibha SINGH , Javeena HUSSAIN , Rupesh CHIKHALE , Richard BRYCE , Sivapriya KIRUBAKARAN
IPC分类号： A61K31/5415 , A61K31/167 , A61P35/00
摘要： A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.
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公开(公告)号：US20200260623P1
公开(公告)日：2020-08-13
申请号：US16350990
申请日：2019-02-08
发明人： Don R. LaBonte
IPC分类号： A01H6/00
摘要： A new variety of sweetpotato, identified as ‘LA17-54’, is disclosed having disease resistance to Fusarium wilt; an orange flesh, red-copper skin storage root and attractive purple, red-hued and green leaves with purple venation and purple vines
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公开(公告)号：US20200222245A1
公开(公告)日：2020-07-16
申请号：US16798707
申请日：2020-02-24
发明人： Osama AHMED
摘要： A cranial cap dressing for dressing a craniotomy wound comprising a breathable elastic outer layer sized to fit snuggly on a human head of a patient and an absorbent inner layer attached to the breathable elastic outer layer.
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公开(公告)号：US10695338B2
公开(公告)日：2020-06-30
申请号：US15571917
申请日：2016-05-06
摘要： Methods and compositions for treating a lysosomal movement associated disease in an animal, in which the position of lysosomes can influence disease progression, comprising administering an effective amount of a first lysosome migration inhibitor or a pharmaceutically acceptable salt, solvate, clathrate, stereoisomer, enantiomer or prodrug thereof.
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公开(公告)号：US10675253B2
公开(公告)日：2020-06-09
申请号：US15935581
申请日：2018-03-26
发明人： Christopher Kevil , Sibile Pardue
IPC分类号： A61K31/105 , A61K38/44 , G01N33/84 , A61P9/10 , A61K33/00
摘要： Methods and therapeutics for treating nitric oxide (NO) mediated condition comprising administering a therapeutically effective amount of a pharmaceutical composition containing a therapeutic, wherein the therapeutic one of increases xanthine oxidase (XO) associated nitrite conversion to nitric oxide and increases nitrite conversion to nitric oxide via DADS. Method and devices for measuring an amount of nitrite in a sample comprising obtaining a sample, adding diallyl disulfide (DADS) to the sample, measuring a post DADS amount of nitric oxide (NO) in the sample, and using the post DADS amount of NO in the sample to determine the amount of nitrite in the sample. Methods and therapeutics for diagnosing and treating critical limb ischemia (CLI) versus non-critical limb ischemic peripheral artery disease (PAD) in a patient comprising determining a patient indicator value, where the patient indicator is value one of a total hydrogen sulfide metabolite plasma level, a total nitric oxide, nitrite, and nitrite (NOx) plasma level, a ratio of free hydrogen sulfide plasma level to total NOx plasma level, and a ratio of total hydrogen sulfide metabolite plasma level and total NOx plasma level, diagnosing the patient with as having CLI based on the patient indicator value, and administering to the patient a therapeutic for CLI.
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公开(公告)号：US20200146220A1
公开(公告)日：2020-05-14
申请号：US16741891
申请日：2020-01-14
摘要： Various examples of methods and systems are provided for increasing productivity of one or more photosynthetic cultures via self-powered energy output systems. In one example, a system includes a waterproof casing and an energy output module enclosed within the waterproof casing. The waterproof casing is configured to be neutrally buoyant in an enclosure comprising the one or more photosynthetic cultures. In another example, a method includes placing a self-powered energy output system within an enclosure, the self-powered energy output system being neutrally buoyant within the enclosure. The method further includes causing turbulence within the enclosure, and the self-powered energy output system harvests energy to power the self-powered energy output system via the turbulence within the enclosure.
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公开(公告)号：US20200085861A1
公开(公告)日：2020-03-19
申请号：US16599710
申请日：2019-10-11
摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
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公开(公告)号：US10545873B2
公开(公告)日：2020-01-28
申请号：US16111827
申请日：2018-08-24
发明人： Lu Peng , Ashok Srivastava , Shaoming Chen
IPC分类号： G06F13/16 , G06F12/0862 , G06F13/40
摘要： Embodiments of the present invention include methods for increasing off-chip bandwidth. The method includes designing a circuit of switchable pins, replacing a portion of allocated pins of a processor with switchable pins, connecting the processor to a memory interface configured to switch the switchable pins between a power mode and a signal mode, providing a metric configured to identify which of the power mode and the signal mode is most beneficial during 1 millisecond intervals, and switching the switchable pins to signal mode during intervals where the signal mode provides more benefit than the power mode.
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公开(公告)号：US10519278B2
公开(公告)日：2019-12-31
申请号：US15687397
申请日：2017-08-25
发明人： Donghui Zhang , Jinbao Cao , Brandon Chan , David Siefker
摘要： Various embodiments disclosed relate to a method of forming a polypeptide. The method includes contacting a first amino acid-derived N-thiocarboxyanhydrosulfide monomer as a crystalline solid with a polymerization initiator (e.g., in an alkane suspension) to give a polypeptide product. The method further includes contacting the polypeptide product with a second amino acid-derived N-thiocarboxyanhydrosulfide monomer in an alkane suspension.
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公开(公告)号：US10393726B2
公开(公告)日：2019-08-27
申请号：US15560028
申请日：2016-03-23
申请人： The University of North Carolina at Chapel Hill , Cornell University , Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： Steven A. Soper , Francis Barany , Sunggook Park , Michael Murphy , Collin J. McKinney , John William Efcavitch , Mateusz Hupert
IPC分类号： G01N33/487 , C12M1/40 , B01L3/00 , C12M3/06 , C12Q1/6806 , C12Q1/6869 , C12Q1/6837 , C12Q1/6874
摘要： The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The device also comprises one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber.
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