公开(公告)号：US08937089B2

公开(公告)日：2015-01-20

申请号：US13207669

申请日：2011-08-11

Applicant: Isaac Billy Annan ,  John Lindsey Flexner ,  Hector Eduardo Portillo ,  George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： Isaac Billy Annan ,  John Lindsey Flexner ,  Hector Eduardo Portillo ,  George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: A01N43/50 ,  A01N43/40 ,  A01N51/00 ,  A01N43/56

CPC classification number: A01N43/56 ,  A01N2300/00

Abstract: Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof and a component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.

Abstract translation: 公开了用于控制与（a）3-溴-N- [4-氯-2-甲基-6 - [（甲基氨基）羰基]苯基] -1-（3-氯-2 - 吡啶基）-1H-吡唑-5-甲酰胺及其N-氧化物及其合适的盐和组分（b），其中组分（b）是至少一种选自新烟碱类，胆碱酯酶抑制剂，钠通道的化合物或药剂 调节剂，壳多糖合成抑制剂，蜕皮激素激动剂，脂质生物合成抑制剂，大环内酯，GABA调节的氯化物通道阻断剂，幼年激素模拟物，兰诺定受体配体，章鱼胺受体配体，线粒体电子传递抑制剂，奈司毒素类似物，吡啶甲酰，氟虫胺，吡蚜酮，狄氏剂 ，间氟lum嗪，生物制剂和上述的合适的盐。 还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物有效量的本发明的混合物或组合物接触。

公开(公告)号：US08921400B2

公开(公告)日：2014-12-30

申请号：US13412659

申请日：2012-03-06

Applicant: George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: A01N43/56 ,  A01N43/16 ,  A01N43/707 ,  C07D213/77 ,  C07C251/76 ,  C07D231/14 ,  C07D231/08 ,  C07D231/16 ,  C07D413/14 ,  C07D401/04 ,  A01N37/38 ,  C07D231/06 ,  C07D413/04

CPC classification number: A01N43/56 ,  A01N37/38 ,  A01N43/16 ,  A01N43/707 ,  C07C251/76 ,  C07D213/77 ,  C07D231/06 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure, and an effective amount of at least one fungicide.

Abstract translation: 本发明提供一种组合物，其包含生物有效量的式1化合物，N-氧化物或其农业上合适的盐，其中R 1，R 2，R 3，R 4a，R 4b和R 5如本公开所定义，并且有效量 的至少一种杀真菌剂。

公开(公告)号：US08697734B2

公开(公告)日：2014-04-15

申请号：US13571852

申请日：2012-08-10

Applicant: George Philip Lahm ,  Stephen Frederick McCann ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： George Philip Lahm ,  Stephen Frederick McCann ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: A01N43/40

CPC classification number: A01N43/56 ,  A01N43/54 ,  A01N43/58 ,  A01N43/86 ,  C07C251/76 ,  C07D213/77 ,  C07D231/06 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention further relates to a benzoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.

Abstract translation: 本发明涉及一种控制鳞翅目，同翅目，半翅目，鳞翅目和鞘翅目昆虫害虫的方法，包括使昆虫或其环境与节肢动物学有效量的式I化合物，其N-氧化物或农业上合适的盐接触，其中A 并且B和R 1至R 8如本公开中所定义。 本发明还涉及式10的苯并恶嗪酮化合物，其中R 4至R 8如本公开所定义，可用于制备式I化合物。

公开(公告)号：US08552218B2

公开(公告)日：2013-10-08

申请号：US13561546

申请日：2012-07-30

Applicant: George Philip Lahm ,  Wesley Lawrence Shoop ,  Ming Xu

Inventor： George Philip Lahm ,  Wesley Lawrence Shoop ,  Ming Xu

IPC: C07C259/10

CPC classification number: A01N43/42 ,  A01M1/10 ,  A01M1/2005 ,  A01N43/80 ,  A61K9/1075 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4725 ,  A61K45/06 ,  C07D215/12 ,  C07D261/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K2300/00

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting of CR3 and N; provided that at most 3 of A1, A2, A3, A4, A5 and A6 is N; B1, B2 and B3 are independently selected from the group consisting of CR2 and N; each R3 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, —CN or —NO2; and R1, R2, R4, R5, W and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，包括所有几何和立体异构体，N-氧化物及其盐，其中A1，A2，A3，A4，A5和A6独立地选自CR3和N; A1，A2，A3，A4，A5和A6中最多有3个为N; B1，B2和B3独立地选自CR2和N; 每个R 3独立地是H，卤素，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6环烷基，C 3 -C 6卤代环烷基，C 1 -C 6烷氧基，C 1 -C 6卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基， C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，C1-C6烷基氨基，C2-C6二烷基氨基，-CN或-NO2; 并且R1，R2，R4，R5，W和n如本公开所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US08410153B2

公开(公告)日：2013-04-02

申请号：US12663751

申请日：2008-06-20

Applicant: George Philip Lahm ,  Jeffrey Keith Long ,  Ming Xu

Inventor： George Philip Lahm ,  Jeffrey Keith Long ,  Ming Xu

IPC: A61K31/42 ,  C07D261/04

CPC classification number: A01N43/80 ,  C07D261/04

Abstract: Disclosed are compounds of Formula 1, wherein R1 is halogen, C1-C2 haloalkyl or C1-C2 haloalkoxy; R2 is H, halogen or cyano; R3 is H, halogen or CF3; R4 is H, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl; and R5 is C1-C6 alkyl or C1-C6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C2-C7 alkylaminocarbonyl, C3-C9 dialkylaminocarbonyl, C2-C7 haloalkylaminocarbonyl and C3-C9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，其中R 1是卤素，C 1 -C 2卤代烷基或C 1 -C 2卤代烷氧基; R2是H，卤素或氰基; R3是H，卤素或CF3; R4是H，C2-C7烷基羰基或C2-C7烷氧基羰基; 并且R 5是被一个独立地选自羟基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基，C 2 -C 7烷基氨基羰基，C 3 -C 6烷基氨基羰基， C 9二烷基氨基羰基，C 2 -C 7卤代烷基氨基羰基和C 3 -C 9卤代二烷基氨基羰基。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US20120277100A1

公开(公告)日：2012-11-01

申请号：US13386065

申请日：2010-08-03

Applicant: Wenming Zhang ,  Caleb William Holyoke, JR. ,  Kenneth Andrew Hughes ,  George Philip Lahm ,  Thomas Francis Pahutski, JR. ,  My-Hanh Thi Tong ,  Ming Xu

Inventor： Wenming Zhang ,  Caleb William Holyoke, JR. ,  Kenneth Andrew Hughes ,  George Philip Lahm ,  Thomas Francis Pahutski, JR. ,  My-Hanh Thi Tong ,  Ming Xu

IPC: A01N43/90 ,  A01C1/06 ,  A01P1/00 ,  C07D471/04

CPC classification number: A01N43/90 ,  A01N25/00 ,  A01N43/54 ,  A01N43/78 ,  A61K31/519 ,  C07D239/54 ,  C07D401/06 ,  C07D417/06 ,  C07D471/04 ,  C07D487/04 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04

Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein X is O or S; Y is O or S; A is O, S, NR3e or C(R3c)═C(R3d); Z is a direct bond, O, S(O)n, NR6, C(R7)2O, OC(R7)2, C(═X1), C(═X1)E, EC(═X1), C(═NOR8) or C(═NN(R6)2); a is 1, 2 or 3; and R1, R2, R3a—R3e, R4, R5, R6, R7, R8, X1 and E are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，N-氧化物及其盐，其中X是O或S; Y为O或S; A是O，S，NR 3e或C（R 3c）= C（R 3d）; Z是直接键，O，S（O）n，NR6，C（R7）2O，OC（R7）2，C（= X1），C（= X1）E，EC（═X1），C NOR8）或C（= NN（R6）2）; a是1,2或3; 并且R1，R2，R3a-R3e，R4，R5，R6，R7，R8，X1和E如本公开所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US08158802B2

公开(公告)日：2012-04-17

申请号：US13017531

申请日：2011-01-31

Applicant: George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: C07D401/04

CPC classification number: A01N43/56 ,  A01N37/38 ,  A01N43/16 ,  A01N43/707 ,  C07C251/76 ,  C07D213/77 ,  C07D231/06 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure. Also disclosed are methods for controlling invertebrate pests comprising contacting the invertebrate pests or their environment with a biologically effective amount of a compound of Formula 1 or a composition comprising a compound of Formula 1.

Abstract translation: 本发明提供式1化合物，其N-氧化物和农业上合适的盐，其中R1，R2，R3，R4a，R4b和R5如本公开所定义。 还公开了用于控制无脊椎动物害虫的方法，包括使无脊椎害虫或其环境与生物有效量的式1化合物或包含式1化合物的组合物接触。

公开(公告)号：US08084468B2

公开(公告)日：2011-12-27

申请号：US12521156

申请日：2008-01-18

Applicant: Robert James Pasteris ,  George Philip Lahm

Inventor： Robert James Pasteris ,  George Philip Lahm

IPC: A61K31/4535 ,  C07D407/02

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein R1, R2, A, G, W1, Q, X, Z, and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

公开(公告)号：US20110263641A1

公开(公告)日：2011-10-27

申请号：US13156653

申请日：2011-06-09

Applicant: George Philip Lahm ,  Wesley Lawrence Shoop ,  Ming Xu

Inventor： George Philip Lahm ,  Wesley Lawrence Shoop ,  Ming Xu

IPC: A61K31/4725 ,  A61P33/00 ,  A61K31/4709 ,  A61P33/14 ,  A61K31/42 ,  A61K31/4439

CPC classification number: A01N43/42 ,  A01M1/10 ,  A01M1/2005 ,  A01N43/80 ,  A61K9/1075 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4725 ,  A61K45/06 ,  C07D215/12 ,  C07D261/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K2300/00

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting of CR3 and N; provided that at most 3 of A1, A2, A3, A4, A5 and A6 is N; B1, B2 and B3 are independently selected from the group consisting of CR2 and N; each R3 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 halo alkylthio, C1-C6 alkyl sulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, —CN or —NO2; and R1, R2, R4, R5, W and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，包括所有几何和立体异构体，N-氧化物及其盐，其中A1，A2，A3，A4，A5和A6独立地选自CR3和N; A1，A2，A3，A4，A5和A6中最多有3个为N; B1，B2和B3独立地选自CR2和N; 每个R 3独立地是H，卤素，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6环烷基，C 3 -C 6卤代环烷基，C 1 -C 6烷氧基，C 1 -C 6卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基，C 1 C 1-6烷基亚磺酰基，C 1 -C 6卤代烷基亚磺酰基，C 1 -C 6烷基磺酰基，C 1 -C 6卤代烷基磺酰基，C 1 -C 6烷基氨基，C 2 -C 6二烷基氨基，-CN或-NO 2; 并且R1，R2，R4，R5，W和n如本公开所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US20100254959A1

公开(公告)日：2010-10-07

申请号：US12663751

申请日：2008-06-20

Applicant: George Philip Lahm ,  Jeffrey Keith Long ,  Ming Xu

Inventor： George Philip Lahm ,  Jeffrey Keith Long ,  Ming Xu

IPC: A61K35/74 ,  C07D261/04 ,  A61K31/42 ,  A61K31/715 ,  A61K31/426 ,  A61K31/44 ,  A61K31/53 ,  A61K31/505 ,  A61K31/4439 ,  A61K31/535 ,  A61K31/7048 ,  A61K35/76 ,  A61P33/00

CPC classification number: A01N43/80 ,  C07D261/04

Abstract: Disclosed are compounds of Formula 1, wherein R1 is halogen, C1-C2 haloalkyl or C1-C2 haloalkoxy; R2 is H, halogen or cyano; R3 is H, halogen or CF3; R4 is H, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl; and R5 is C1-C6 alkyl or C1-C6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C2-C7 alkylaminocarbonyl, C3-C9 dialkylaminocarbonyl, C2-C7 haloalkylaminocarbonyl and C3-C9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，其中R 1是卤素，C 1 -C 2卤代烷基或C 1 -C 2卤代烷氧基; R2是H，卤素或氰基; R3是H，卤素或CF3; R4是H，C2-C7烷基羰基或C2-C7烷氧基羰基; 并且R 5是被一个独立地选自羟基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基，C 2 -C 7烷基氨基羰基，C 3 -C 6烷基氨基羰基， C 9二烷基氨基羰基，C 2 -C 7卤代烷基氨基羰基和C 3 -C 9卤代二烷基氨基羰基。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。