公开(公告)号：US20220176107A1

公开(公告)日：2022-06-09

申请号：US17593664

申请日：2020-03-25

Applicant: Galvani Bioelectronics Limited

Inventor： Kenneth Douglas RYS

IPC: A61N1/05 ,  A61N1/36

Abstract: A neural interface system, comprises a lead body including a first electrode; a cuff body having a first section and a second section separated by a gap for providing a path of least electrical resistance, a second electrode positioned within the first section; and a junction between the lead body and the cuff body, wherein the gap extends around an axis of the cuff body and comprises a first area proximal to the junction.

公开(公告)号：US11167143B2

公开(公告)日：2021-11-09

申请号：US16485673

申请日：2018-02-12

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc Pepin ,  Shiv Sabesan

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US20210290949A1

公开(公告)日：2021-09-23

申请号：US16321214

申请日：2017-07-27

Applicant: GALVANI BIOELECTRONICS LIMITED ,  TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bradley J. HOLINSKI ,  Timothy GARDNER ,  Charles A. LISSANDRELLO ,  Alice E. WHITE ,  Winthrop GILLIS ,  Jun SHEN ,  Timothy OTCHY ,  Christos MICHAS

IPC: A61N1/05 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/124

Abstract: Implantable nerve cuffs and methods for constructing or manufacturing the same are provided. Also provided is a method for installing a nerve into a nerve passage in the nerve cuff and a system using the nerve cuff. The nerve cuff is configured to retain one or more signal carrying elements such as electrodes proximal to a peripheral nerve in a human or animal subject. The nerve cuff may be constructed using a 3D printing method.

公开(公告)号：USD926316S1

公开(公告)日：2021-07-27

申请号：US29664368

申请日：2018-09-24

Applicant: Galvani Bioelectronics Limited

Designer： Peng Cong ,  Benjamin K. Yaffe ,  Morten Hansen

公开(公告)号：US20210137463A1

公开(公告)日：2021-05-13

申请号：US16622675

申请日：2018-06-22

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UCL BUSINESS LTD

Inventor： Kirill ARISTOVICH ,  David Holder ,  Daniel CHEW ,  Matteo DONEGA

IPC: A61B5/00 ,  A61B5/11 ,  A61N1/36 ,  G16H50/20 ,  G16H40/67 ,  G16H20/30

Abstract: There is provided a nerve activity monitoring method that includes receiving an input signal indicative of activity in a nerve of a subject; receiving physiological data indicative of physiological activity in the subject; establishing a relationship between the physiological data and the input signal; identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and outputting the periodic portions identified.

公开(公告)号：US20210093874A1

公开(公告)日：2021-04-01

申请号：US16955362

申请日：2018-12-21

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： ERIC IRWIN ,  ANDREW HINDMARSH ,  JOHN BENNETT

IPC: A61N1/375 ,  A61B17/3209 ,  A61N1/378

Abstract: An implantation system and methods of inserting an implant are disclosed. The method includes the step of making an incision in an abdominal wall with an instrument positioned within an abdominal cavity. The method further includes the steps of forming a pocket between a first surface of the abdominal wall and a second surface of the abdominal wall, such that the incision defines an opening into the pocket, inserting an implant through the opening and into the pocket, and closing the opening such that the implant is captured within the pocket.

公开(公告)号：US20210093853A1

公开(公告)日：2021-04-01

申请号：US15733239

申请日：2018-12-14

Applicant: Galvani Bioelectronics Limited

Inventor： Benjamin YAFFE ,  Kenneth Douglas RYS

IPC: A61N1/05

Abstract: An implant insertion system and methods of use of the implant insertion system are disclosed. The implant insertion system includes an implant and an instrument configured to deliver the implant to a biological structure and assist in deploying the implant to the biological structure. The instrument includes a retention member the secures the implant to the instrument and retains the implant in a first configuration. The retention member is movable to decouple the implant from the instrument. The implant is configured to transition from the first configuration to a second configuration, such that in the second configuration the implant is secured to the biological structure.

公开(公告)号：US10960209B2

公开(公告)日：2021-03-30

申请号：US16320288

申请日：2017-07-25

Applicant: Galvani Bioelectronics Limited ,  Case Western Reserve University

Inventor： Arun Sridhar ,  Corey Smith ,  Kyle Wolf ,  Georgy Zarkua ,  Shyue-An Chan

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.

公开(公告)号：US20210085977A1

公开(公告)日：2021-03-25

申请号：US16955345

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： DANIEL JOHN CHEW ,  MATTEO DONEGA ,  ISHA GUPTA

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：US20200324111A1

公开(公告)日：2020-10-15

申请号：US16955331

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： MATTEO DONEGA ,  DANIEL JOHN CHEW ,  MARGRIET VERVOORDELDONK ,  ISHA GUPTA

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/378

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.