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公开(公告)号:US10464955B2
公开(公告)日:2019-11-05
申请号:US15118726
申请日:2014-02-28
发明人: Robert Yongxin Zhao , Xing Li , Yuangyuang Huang , Qingliang Yang
IPC分类号: C07F9/30 , C07F9/58 , C07F9/572 , C07F9/6558 , C07F9/6561 , A61K38/07 , C07F9/32 , A61K47/68
摘要: Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.
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公开(公告)号:US20190125894A1
公开(公告)日:2019-05-02
申请号:US16226093
申请日:2018-12-19
发明人: Sanxing SUN , Robert Yongxin ZHAO , Xing LI , Huihui GUO , Junxiang JIA , Hongsheng XIE , Xiaomai ZHOU , Yuanyuan HUANG , Qingliang YANG , Xiaotao ZHUO , Hangbo YE , Shun GAI , Lan QU , Wenjun LI , Chen LIN
IPC分类号: A61K47/68 , C07F9/572 , C07K16/28 , C07K16/00 , C07F9/6558 , C07D207/46
摘要: Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.
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公开(公告)号:US10131682B2
公开(公告)日:2018-11-20
申请号:US14432073
申请日:2012-11-24
发明人: R. Yongxin Zhao
IPC分类号: A61K31/454 , C07D207/46 , C07D401/12 , C07F9/30 , C07F9/572 , C07F9/6558 , A61K31/10 , A61K31/662 , C07F9/6561 , C07F9/32 , A61K47/68 , C07F9/58
摘要: Cell binding agent-drug conjugates comprising hydrophilic linkers, and methods of using such linkers and conjugates are provided.
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公开(公告)号:US20180021448A9
公开(公告)日:2018-01-25
申请号:US14253881
申请日:2014-04-16
发明人: R. Yongxin Zhao , Yue Zhang , Yourang Ma
IPC分类号: A61K45/06
CPC分类号: C07D207/40 , A61K45/06 , A61K47/64 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6867 , Y02A50/412 , Y02A50/416
摘要: A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
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