公开(公告)号：US20150362671A1

公开(公告)日：2015-12-17

申请号：US14690473

申请日：2015-04-20

Applicant: James Dalton Bell

Inventor： James Dalton Bell

IPC: G02B6/02 ,  G02B1/00 ,  G02B6/028

CPC classification number: G02B6/02395 ,  C03C3/04 ,  C03C13/045 ,  C03C13/046 ,  C03C2201/31 ,  C03C2213/00 ,  G02B1/00 ,  G02B6/02 ,  G02B6/028 ,  G02B6/0281 ,  G02B6/0286 ,  G02B2006/12061

Abstract: An optical waveguide having a cladding layer formed of high-purity glass, or a cladding layer formed of high-purity isotope-proportion modified glass, and with a core of high-purity isotope-proportion-modified glass with the index of refraction of the core glass greater than the index of refraction of the cladding glass, said high-purity isotope-proportion-modified core material having a Si-29-isotope proportion at most 4.447% Si-29 (atom/atom) of all silicon atoms in said core, or at least 4.90% of Si-29 (atom/atom) atoms in said core, or having a Ge-73 isotope proportion of at most 7.2% Ge-73 (atom/atom) of all germanium atoms in said core, or at least 8.18% of Ge-73 (atom/atom) of Germanium atoms in said core region.

公开(公告)号：US07988641B2

公开(公告)日：2011-08-02

申请号：US12771151

申请日：2010-04-30

Applicant: Michael McCawley ,  Gary Gasner ,  Ian Christie ,  Tal Gottesman ,  James Dalton

Inventor： Michael McCawley ,  Gary Gasner ,  Ian Christie ,  Tal Gottesman ,  James Dalton

IPC: A61B5/08

CPC classification number: A61B5/085 ,  A61B5/0813

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract translation: 一种用于测量肺通气的装置，包括：用于测量空气流量的压力装置; 气溶胶发生装置，其提供将在呼吸循环中的确定点释放的气溶胶颗粒; 具有检测器的喉舌，其在呼吸循环期间测量给定体积的气溶胶颗粒的浓度; 以及被配置为提供肺通气数据作为时间常数的函数的计算设备。

公开(公告)号：US07731666B2

公开(公告)日：2010-06-08

申请号：US11771479

申请日：2007-06-29

Applicant: Michael McCawley ,  Gary Ganser ,  Ian Christie ,  Tal Gottesman ,  James Dalton

Inventor： Michael McCawley ,  Gary Ganser ,  Ian Christie ,  Tal Gottesman ,  James Dalton

IPC: A61B5/00

CPC classification number: A61B5/085 ,  A61B5/0813

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract translation: 一种用于测量肺通气的装置，包括：用于测量空气流量的压力装置; 气溶胶发生装置，其提供将在呼吸循环中的确定点释放的气溶胶颗粒; 具有检测器的喉舌，其在呼吸循环期间测量给定体积的气溶胶颗粒的浓度; 以及被配置为提供肺通气数据作为时间常数的函数的计算设备。

公开(公告)号：US20080027105A1

公开(公告)日：2008-01-31

申请号：US11841241

申请日：2007-08-20

Applicant: Jose-Ramon SUAREZ ,  John BYRD ,  Michael GREVER ,  James DALTON ,  Thomas LIN

Inventor： Jose-Ramon SUAREZ ,  John BYRD ,  Michael GREVER ,  James DALTON ,  Thomas LIN

IPC: A61K31/452

CPC classification number: A61K31/453 ,  A61K9/0019

Abstract: A dosing regimen comprising a therapeutically effective amount of flavopiridol or a pharmaceutically acceptable salt thereof optionally in combination with a pharmaceutically acceptable carrier suitable for bolus infusion and subsequently for infusion is disclosed and claimed. Also disclosed and claimed is a method of treating a variety of cancers in a patient comprising administering to said patient the dosing regimen of the invention.

Abstract translation: 公开和要求保护的包含治疗有效量的类风素或其药学上可接受的盐的给药方案，其任选地与适合于推注和随后输注的药学上可接受的载体组合。 还公开并要求保护的是治疗患者中各种癌症的方法，包括向所述患者施用本发明的给药方案。

公开(公告)号：US20070281906A1

公开(公告)日：2007-12-06

申请号：US11785064

申请日：2007-04-13

Applicant: James Dalton ,  Duane Miller

Inventor： James Dalton ,  Duane Miller

IPC: A61K31/167 ,  A61K31/277 ,  A61K31/32 ,  A61K31/404 ,  A61K31/47 ,  A61K31/555 ,  A61K31/66 ,  A61K31/675 ,  A61P25/02 ,  A61P3/10 ,  A61P9/00

CPC classification number: A61K31/167 ,  A61K31/277 ,  A61K31/32 ,  A61K31/404 ,  A61K31/47 ,  A61K31/555 ,  A61K31/66 ,  A61K31/675

Abstract: This invention provides use of a SARM compound or a composition comprising the same in treating a variety of diseases or conditions in a subject, including, inter-alia, a diabetes disease, and/or disorder such as cardiovascular disease, atherosclerosis, cerebrovascular conditions, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.

Abstract translation: 本发明提供了SARM化合物或其组合物在治疗受试者中的多种疾病或病症中的用途，包括尤其是糖尿病疾病和/或病症如心血管疾病，动脉粥样硬化，脑血管病症， 糖尿病性肾病，糖尿病性神经病变和糖尿病性视网膜病变。

公开(公告)号：US20070274940A1

公开(公告)日：2007-11-29

申请号：US11805392

申请日：2007-05-23

Applicant: Janice Fuls ,  Nancy Rodgers ,  Priscilla Fox ,  James Dalton ,  Harry Towner ,  Daniel Pedersen ,  John Rolando ,  Richard Staub

Inventor： Janice Fuls ,  Nancy Rodgers ,  Priscilla Fox ,  James Dalton ,  Harry Towner ,  Daniel Pedersen ,  John Rolando ,  Richard Staub

IPC: A61K31/185 ,  A61K31/19 ,  A61K31/045

CPC classification number: A01N31/02 ,  A01N25/00 ,  A01N37/04 ,  A01N37/36 ,  A61K31/045 ,  A61K31/192 ,  A61K31/194 ,  A61K31/78 ,  A01N35/02 ,  A01N47/36 ,  A01N37/02 ,  A01N2300/00

Abstract: A method of imparting a rapid antiviral effectiveness, and a persistent antiviral effectiveness, to an animate surface is disclosed. The method includes first treating the animate surface with a preconditioning composition, followed by treating the animate surface with an antiviral composition.

Abstract translation: 公开了赋予动画表面快速抗病毒效能和持久抗病毒效能的方法。 该方法包括首先用预处理组合物处理动画表面，然后用抗病毒组合物处理动画表面。

公开(公告)号：US07174223B2

公开(公告)日：2007-02-06

申请号：US10798847

申请日：2004-03-12

Applicant: James Dalton ,  Peter Single ,  David Money

Inventor： James Dalton ,  Peter Single ,  David Money

IPC: A61N1/00

CPC classification number: A61N1/3754 ,  A61N1/36036 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A virtual wire assembly is disclosed. The assembly comprises a substantially electrically-nonconductive substrate; and a plurality of hermetic feedthroughs each comprising a conductive region extending transversely through the substrate to form a conductive pathway with accessible surfaces at opposing ends thereof, wherein each conductive pathway is electrically isolated from other conductive pathways. In certain embodiments of this aspect of the invention, the substantially electrically-nonconductive substrate is a semiconductor device, and the conductive regions each are comprised of an n-type or a p-type doped semiconductor material. Also disclosed are implanted medical devices requiring electronic or other components to be retained in a hermetic enclosure, such as cochlear and other sensory or neural prosthetic devices.

Abstract translation: 公开了虚拟线组件。 该组件包括基本上非导电的基底; 以及多个密封馈通，每个包括横向延伸通过衬底的导电区域，以在其相对端形成具有可接近表面的导电路径，其中每个导电路径与其它导电路径电隔离。 在本发明的这个方面的某些实施例中，基本上非导电衬底是半导体器件，并且导电区域各自由n型或p型掺杂半导体材料构成。 还公开了植入式医疗装置，其需要将电子或其它部件保持在密封外壳中，例如耳蜗和其他感觉或神经假肢装置。

公开(公告)号：US20060276540A1

公开(公告)日：2006-12-07

申请号：US11353225

申请日：2006-02-14

Applicant: James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

Inventor： James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

IPC: A61K31/277 ,  C07C255/20

CPC classification number: C07C255/60

Abstract: The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia,osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas.

Abstract translation: 本发明涉及雄激素和合成代谢活性的雄激素受体靶向剂（ARTA），其是雄激素受体的非甾体配体。 选择性雄激素受体调节剂（SARM）可用于a）男性避孕; b）治疗各种激素相关病症，例如与老年雄性雄激素降低有关的病症（ADAM），如疲劳，抑郁，性欲降低，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血， 肥胖，肌营养不良，骨质减少，骨质疏松症，良性前列腺增生，情绪和认知和前列腺癌的改变; c）治疗与男性雄激素降低相关的病症（ADIF），如性功能障碍，性欲降低，性腺机能减退，肌营养不良，骨质减少，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖，子宫内膜异位症，乳腺癌 癌症，子宫癌和卵巢癌; d）治疗和/或预防慢性肌肉消瘦; e）降低前列腺癌的发生率，停止或导致消退; f）口服雄激素替代和/或其他临床治疗和/或诊断领域。

公开(公告)号：US20060183931A1

公开(公告)日：2006-08-17

申请号：US10371155

申请日：2003-02-24

Applicant: James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka ,  Dong Hwang ,  Jiyun Chen

Inventor： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka ,  Dong Hwang ,  Jiyun Chen

IPC: C07F9/02 ,  C07F7/22 ,  C07C395/00 ,  C07C255/60 ,  C07C237/10

CPC classification number: C07C235/24

Abstract: This invention provides androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; and/or g) decreasing the incidence of, halting or causing a regression of prostate cancer

Abstract translation: 本发明提供雄激素受体靶向剂（ARTA）。 这些药剂定义了一种新的化合物亚类，它们是选择性雄激素受体调节剂（SARM）。 已经发现几种SARM化合物对雄激素受体具有非甾类化合物的意想不到的雄激素和合成代谢活性。 已经发现其他SARM化合物对雄激素受体具有非甾类配体的意想不到的抗雄激素活性。 SARM化合物，单独或作为组合物，可用于a）男性避孕; b）治疗各种激素相关病症，例如与老年雄性雄激素降低有关的病症（ADAM），如疲劳，抑郁，性欲降低，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血， 肥胖，肌营养不良，骨质减少，骨质疏松症，良性前列腺增生，情绪和认知和前列腺癌的改变; c）治疗与男性雄激素降低相关的病症（ADIF），如性功能障碍，性欲降低，性腺机能减退，肌营养不良，骨质减少，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖，子宫内膜异位症，乳腺癌 癌症，子宫癌和卵巢癌; d）治疗和/或预防急性和/或慢性肌肉消瘦病症; e）预防和/或治疗干眼症状; f）口服雄激素替代疗法; 和/或g）降低前列腺癌的发生率，停止或导致消退

公开(公告)号：US20060095595A1

公开(公告)日：2006-05-04

申请号：US10977896

申请日：2004-10-29

Applicant: James Dalton ,  Eric Kern

Inventor： James Dalton ,  Eric Kern

IPC: G06F3/00

CPC classification number: G06F1/3209 ,  G06F1/3221 ,  Y02D10/154

Abstract: Local drive presence is provided for local and remote drives by maintaining a plurality of uninterrupted protocol connections between a plurality of I/O controllers and a plurality of device interfaces through which peripheral bus commands are transmitted. Preferably, the I/O controllers are each housed in a separate server blade and provide each blade with access to the local and remote drives. At each of the device interfaces, rather than attaching an actual storage device, peripheral bus commands received at the device interfaces are serialized and conditionally passed or suppressed to and from the shared drive which is shared amongst the plurality of uninterrupted protocol connections. Preferably, the plurality of uninterrupted protocol connections is maintained such that the shared drives can be simultaneously shared. In one embodiment, the local drives are provided in a media tray which is shared amongst a plurality blades.

Abstract translation: 通过在多个I / O控制器和通过其发送外围总线命令的多个设备接口之间维持多个不间断的协议连接来为本地和远程驱动器提供本地驱动器存在。 优选地，I / O控制器各自容纳在单独的服务器刀片中，并且为每个刀片提供对本地和远程驱动器的访问。 在每个设备接口上，而不是附加实际的存储设备，在设备接口处接收的外围设备总线命令被串行化并有条件地传递或抑制到在多个不间断协议连接之间共享的共享驱动器。 优选地，保持多个不间断的协议连接，使得共享驱动器可以被同时共享。 在一个实施例中，本地驱动器设置在介于多个叶片之间共享的介质托盘中。