公开(公告)号：US20090131405A1

公开(公告)日：2009-05-21

申请号：US12299864

申请日：2007-05-24

Applicant: Francis Fang ,  Shawn Schiller ,  Boris Seletsky ,  Mark Spyvee

Inventor： Francis Fang ,  Shawn Schiller ,  Boris Seletsky ,  Mark Spyvee

IPC: A61K31/55

CPC classification number: A61K31/435 ,  A61K31/55

Abstract: The invention relates to compounds of formula I: along with pharmaceutical compositions containing the same and methods of use thereof for the treatment of autoimmune disease.

Abstract translation: 本发明涉及式I化合物：以及含有其的药物组合物及其用于治疗自身免疫性疾病的方法。

公开(公告)号：US20080103137A1

公开(公告)日：2008-05-01

申请号：US11906056

申请日：2007-09-28

Applicant: Jane Daun ,  Heather Davis ,  Bruce DeCosta ,  Fabian Gusovsky ,  Ieharu Hishinuma ,  Yimin Jiang ,  Toshihiko Kaneko ,  Kouichi Kikuchi ,  Seiichi Kobayashi ,  Andre Lescarbeau ,  Xiang-Yi Li ,  Kenzo Muramoto ,  Norihito Ohi ,  Marc Pesant ,  Boris Seletsky ,  Motohiro Soejima ,  Mark Spyvee ,  Lynda Tremblay ,  Ye Yao ,  Hiromitsu Yokohama ,  Yan (Janet) Zhao ,  Wanjun Zheng

Inventor： Jane Daun ,  Heather Davis ,  Bruce DeCosta ,  Fabian Gusovsky ,  Ieharu Hishinuma ,  Yimin Jiang ,  Toshihiko Kaneko ,  Kouichi Kikuchi ,  Seiichi Kobayashi ,  Andre Lescarbeau ,  Xiang-Yi Li ,  Kenzo Muramoto ,  Norihito Ohi ,  Marc Pesant ,  Boris Seletsky ,  Motohiro Soejima ,  Mark Spyvee ,  Lynda Tremblay ,  Ye Yao ,  Hiromitsu Yokohama ,  Yan (Janet) Zhao ,  Wanjun Zheng

IPC: A61K31/4745 ,  A61K31/5377 ,  A61P11/06 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P35/00 ,  A61P9/00 ,  C07D413/14 ,  C07D471/02

CPC classification number: A61K31/437 ,  C07D471/04

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds

Abstract translation: 如上所述，仍然需要开发可用于治疗炎性或自身免疫性和增殖性疾病的新型治疗剂。 本发明提供通式（I）的新化合物及其药物组合物，如本文中一般和本课题和亚类所述，以及制备和使用这些化合物的方法

公开(公告)号：US20060154872A1

公开(公告)日：2006-07-13

申请号：US11340256

申请日：2006-01-26

Applicant: Silvio Campagna ,  Francis Fang ,  James Kowalczyk ,  Shawn Schiller ,  Boris Seletsky ,  Mark Spyvee ,  Hu Yang

Inventor： Silvio Campagna ,  Francis Fang ,  James Kowalczyk ,  Shawn Schiller ,  Boris Seletsky ,  Mark Spyvee ,  Hu Yang

IPC: A61K38/05

CPC classification number: C07D207/04 ,  C07D207/12 ,  C07D207/16 ,  C07D207/42 ,  C07D209/20 ,  C07D211/60 ,  C07D217/26 ,  C07D223/06 ,  C07D233/84 ,  C07D237/04 ,  C07D241/04 ,  C07D265/30 ,  C07D277/06 ,  C07D279/12 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/12 ,  C07D471/04 ,  C07K5/0205 ,  C07K5/0207 ,  C07K5/0821

Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.