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公开(公告)号:US11566279B2
公开(公告)日:2023-01-31
申请号:US16244058
申请日:2019-01-09
申请人: The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College
发明人: Aviv Regev , Evan Zane Macosko , Steven Andrew McCarroll , Alexander K. Shalek , Anindita Basu , Christopher B. Ford , Hongkun Park , David A. Weitz
IPC分类号: C12Q1/6809 , C12Q1/6834 , C12Q1/6869 , C12N15/10 , G06K19/06
摘要: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
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公开(公告)号:US11564970B2
公开(公告)日:2023-01-31
申请号:US16754668
申请日:2018-10-09
发明人: Paul Blainey , Anthony Kulesa , Jared Kehe
IPC分类号: A61K38/08 , A61K38/14 , A61K38/12 , A61K45/06 , A61P31/04 , C07K7/14 , C07K7/64 , A61K31/14 , A61K31/165 , A61K31/4164 , A61K31/4704 , A61K31/506 , A61K31/7048
摘要: Compositions and methods for combinatorial drug discovery in nanoliter droplets are described. Novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infection are disclosed.
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公开(公告)号:US20230026439A1
公开(公告)日:2023-01-26
申请号:US17864349
申请日:2022-07-13
IPC分类号: G01N11/08
摘要: Apparatuses and methods designed to allow for on-site, on-demand measurement of rheological properties of a sample are disclosed. The apparatuses and methods utilize both a visual component (e.g., a camera) to obtain information about the sample for making such rheological property determinations and an integrated electrical circuit to apply a current to the sample for also making such rheological property determinations. The application of the current is done in a manner such that a thinning behavior of the sample is unaffected. Further, the apparatuses are configured in a manner that allow them to be portable so that samples can be analyzed shortly after they are received, at a point-of-use. Various configurations and methods associated with such apparatuses are also disclosed.
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公开(公告)号:US11562584B2
公开(公告)日:2023-01-24
申请号:US16844323
申请日:2020-04-09
发明人: Jong Kang Park , Dushan Wadduwage , Yi Xue , Elly Nedivi , Peter T. C. So , Christopher Rowlands , Kalen Berry
摘要: Systems and methods herein provide improved, high-throughput multiphoton imaging of thick samples with reduced emission scattering. The systems and methods use structured illumination to modify the excitation light. A reconstruction process can be applied to the resulting images to recover image information free of scattering. The disclosed systems and methods provide high throughput, high signal-to-noise ratio, and high resolution images that are depth selective.
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公开(公告)号:US20230019034A1
公开(公告)日:2023-01-19
申请号:US17863784
申请日:2022-07-13
摘要: A test article described herein enables ground-based arc jet testing to investigate RF blackout mitigation using electrophilic gas injection upstream of an antenna. The article can be scaled up to actual flight vehicles, thereby allowing reentry vehicles to be in constant, or near constant, communication during atmospheric reentry. Plasma blackout mitigation is an enabling technology that is required to advance hypersonic flight. Example articles include an integral structure that supports a nozzle, piping for gas connected to the nozzle and an RF window. An ablator can be attached to the structure. The ablator can include a graphite ablator and an insulator. A flight vehicle can include an antenna and such an article.
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公开(公告)号:US11557459B2
公开(公告)日:2023-01-17
申请号:US17469314
申请日:2021-09-08
发明人: Nir Shavit , Aravinathan Samuel , Jeff Lichtman , Lu Mi
摘要: A system and method is provided for rapidly collecting high quality images of a specimen through controlling a re-focusable beam of an electron microscope. An intelligent acquisition system instructs the electron microscope to perform an initial low-resolution scan of a sample. A low-resolution image of the sample is received by the intelligent acquisition system as scanned image information from the electron microscope. The intelligent acquisition system then determines regions of interest within the low-resolution image and instructs the electron microscope to perform a high-resolution scan of the sample, only in areas of the sample corresponding to the determined regions of interest or portions of the determined regions of interest, so that other regions within the sample are not scanned at high-resolution, where the high-resolution scanning in the regions of interest is guided by a probability map using a deep neural network for segmentation.
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公开(公告)号:US11556769B2
公开(公告)日:2023-01-17
申请号:US16860324
申请日:2020-04-28
发明人: Alexander Wynn
IPC分类号: G06F17/00 , G06N3/063 , G06N10/00 , G06N3/04 , H03K19/195
摘要: In some embodiments, a superconducting parametric amplification neural network (SPANN) includes neurons that operate in the analog domain, and a fanout network coupling the neurons that operates in the digital domain. Each neuron is provided one or more input currents having a resolution of several bits. The neuron weights the currents, sums the weighted currents with an optional bias or threshold current, then applies a nonlinear activation function to the result. The nonlinear function is implemented using a quantum flux parametron (QFP), thereby simultaneously amplifying and digitizing the output current signal. The digitized output of some or all neurons in each layer is provided to the next layer using a fanout network that operates to preserve the digital information held in the current.
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公开(公告)号:US11555060B2
公开(公告)日:2023-01-17
申请号:US17210837
申请日:2021-03-24
发明人: David Jin , Rui Qing , Shuguang Zhang
IPC分类号: C07K14/715 , A61K35/17 , A61K38/00
摘要: The present invention is directed to QTY Fc receptor fusion proteins, methods for the preparation thereof and methods of use thereof.
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公开(公告)号:US11552246B2
公开(公告)日:2023-01-10
申请号:US17153744
申请日:2021-01-20
发明人: Jeehwan Kim , Hanwool Yeun , Scott Tan , Peng Lin , Yongmo Park , Chanyeol Choi
摘要: Memristors, including memristors comprising a Schottky barrier, and related systems and methods are generally described.
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公开(公告)号:US11547672B2
公开(公告)日:2023-01-10
申请号:US16510463
申请日:2019-07-12
发明人: Darrell J. Irvine , Murillo Silva , Shane Crotty , Yu Kato
IPC分类号: A61K9/51 , A61K47/69 , B82Y5/00 , B82Y40/00 , A61K9/00 , A61K39/39 , A61K9/19 , A61K39/02 , A61K39/00 , A61K9/14
摘要: Non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin are provided. The particles are porous, cage-like nanoparticles, also referred to as nanocages, and are typically between about 30 nm and about 60 nm. In some embodiments, the nanocages include or are administered in combination with an antigen. The particles can increase immune responses and are particularly useful as adjuvants in vaccine applications and related methods of treatment. Preferred lipids, additional adjuvants including TLR4 agonists, sterols, and saponins, methods of making the nanocages, and method of using them are also provided.
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