公开(公告)号：US20230219920A1

公开(公告)日：2023-07-13

申请号：US18009440

申请日：2021-06-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Yonggang LIAO ,  Changqing WEI ,  Zhengying XI ,  Yao XIAO ,  Shuhui CHEN

IPC分类号： C07D333/34 ,  C07D277/36 ,  C07D409/12 ,  A61P19/06

CPC分类号： C07D333/34 ,  C07D277/36 ,  C07D409/12 ,  A61P19/06

摘要： Disclosed in the present invention is a series of dimethylsulfoximine derivatives, and specifically disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US11680070B2

公开(公告)日：2023-06-20

申请号：US15734906

申请日：2019-06-05

申请人： MEDSHINE DISCOVERY INC.

发明人： Xiaoping Zheng ,  Zhigan Jiang ,  Haiying He ,  Jie Li ,  Zhen Gong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D495/04 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P17/10 ,  A61P35/00 ,  A61K31/522

CPC分类号： C07D495/04 ,  A61P1/16

摘要： Disclosed are a thieno[2,3-c]pyridazin-4(1H)-one derivative as an ACC1 or ACC2 inhibitor and an application thereof in preparing a drug as an ACC1 or ACC2 inhibitor. In particular, disclosed is a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

公开(公告)号：US20230183221A1

公开(公告)日：2023-06-15

申请号：US17998355

申请日：2021-05-19

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Yuyong BA ,  Shuhui CHEN

IPC分类号： C07D405/14

CPC分类号： C07D405/14

摘要： Disclosed are a series of compounds having pyridine structures or pharmaceutically acceptable salts thereof, and an application thereof in the preparation of drugs for the treatment of related diseases. Specifically, disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230174524A1

公开(公告)日：2023-06-08

申请号：US18000684

申请日：2021-06-17

申请人： MEDSHINE DISCOVERY INC.

发明人： Peng LI ,  Chong SU ,  Xiaolin LI ,  Zhi LUO ,  Haiying HE ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D417/04 ,  A61P27/04

CPC分类号： C07D417/04 ,  A61P27/04

摘要： An aminopyridine compound that may be used as an aldehyde trapping agent, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US11649239B2

公开(公告)日：2023-05-16

申请号：US17044127

申请日：2019-04-28

申请人： Medshine Discovery Inc.

发明人： Kevin X. Chen ,  Yanxin Yu ,  Xinde Chen ,  Li Zhang ,  Zhaoguo Chen ,  Cheng Xie

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  C07B2200/13

摘要： Disclosed in the present invention are a crystal form of a [1,2,4]triazolo[1,5-c]pyrimidine compound and a preparation method thereof. Further disclosed is a use of the crystal form in the preparation of a medicament for treating A2A receptor related diseases.

公开(公告)号：US20230132370A9

公开(公告)日：2023-04-27

申请号：US17258011

申请日：2019-07-05

申请人： MEDSHINE DISCOVERY INC.

发明人： Weihua SHI ,  Zhigan JIANG ,  Haiying HE

IPC分类号： C07D417/12 ,  A61P31/22

摘要： Disclosed by the present invention are a crystal form A of a compound represented by formula (I), a compound represented by formula (II) and a crystal form B thereof, as well as an application of the crystal form A of the compound represented by formula (I), the compound represented by formula (II) and the crystal form B thereof in the preparation of a drug for the treatment diseases associated with the herpes simplex virus.

公开(公告)号：US11623923B2

公开(公告)日：2023-04-11

申请号：US16766510

申请日：2018-11-23

申请人： MEDSHINE DISCOVERY, INC.

发明人： Jinping Li ,  Xiongbin Xu ,  Gang Li ,  Lihong Hu ,  Charles Z. Ding ,  Yaling Zhou ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61P35/00 ,  C07D405/14 ,  C07D487/04

摘要： Provided are a uracil compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition of the same. Also provided is a use thereof as a c-MET/AXL inhibitor in preparing a c-MET/AXL-inhibiting drug or a drug for treating a tumor.

公开(公告)号：US20230056559A1

公开(公告)日：2023-02-23

申请号：US17427185

申请日：2020-01-22

申请人： MEDSHINE DISCOVERY INC.

发明人： Xile LIU ,  Charles Z. DING ,  Shuhui CHEN ,  Lihong HU ,  Haiwen WAN

IPC分类号： C07D487/04 ,  C07D401/14 ,  C07D491/052 ,  C07D495/04 ,  C07D491/048 ,  C07D471/14 ,  A61P35/00

摘要： Disclosed are a pyrimidinyl group-containing tricyclic compound and applications thereof in preparing a cancer-treating medicament. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt of same, or an isomer thereof.

公开(公告)号：US20230044606A1

公开(公告)日：2023-02-09

申请号：US17782850

申请日：2020-12-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Yi LI ,  Ning LIU ,  Tao YU ,  Chengde WU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D513/20 ,  A61P35/00 ,  A61P1/00

摘要： A Spiro compound serving as an ERK inhibitor, and an application thereof in preparing a drug for treating an ERK-related disease. The present invention specifically relates to a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11572372B2

公开(公告)日：2023-02-07

申请号：US16764129

申请日：2018-11-16

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Lifang Wu ,  Fei Sun ,  Jinhua Du ,  Charles Z. Ding ,  Shuhui Chen ,  Xiquan Zhang ,  Hongjiang Xu ,  Ling Yang

IPC分类号： C07D498/04 ,  A61P31/20

摘要： Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).