公开(公告)号：US09663428B2

公开(公告)日：2017-05-30

申请号：US14455293

申请日：2014-08-08

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07C33/14 ,  A61K31/415 ,  A61K45/06 ,  A61K47/48 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/495 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00

CPC classification number: C07C33/14 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene for sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US09580372B2

公开(公告)日：2017-02-28

申请号：US14455371

申请日：2014-08-08

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07C33/14 ,  A61K31/415 ,  A61K45/06 ,  A61K47/48 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/495 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00

CPC classification number: C07C33/14 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。 例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。 紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。 给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

公开(公告)号：US20160243114A1

公开(公告)日：2016-08-25

申请号：US15026649

申请日：2014-10-08

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen

IPC: A61K31/495 ,  A61K31/045 ,  A61K45/06 ,  A61K47/48

CPC classification number: A61K31/495 ,  A61K9/0043 ,  A61K9/0085 ,  A61K47/54 ,  A61K47/55

Abstract: A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ−POH. The brain metastases can be originated or spread from breast cancer. The penllyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. The chemotherapeutic agents that may be used in the present invention include a DNA alkylating agent, a topoisomerase inhibitor, an endoplasmic reticulum stress inducing agent, a platinum compound, an antimetabolite, an enzyme inhibitor, and a receptor antagonist.

Abstract translation: 用于治疗哺乳动物的癌症的脑转移的方法包括向哺乳动物施用治疗有效量的诸如TMZ-POH的硫酸氨基甲酸酯。 脑转移可以起源于或从乳腺癌扩散。 噻吩醇衍生物可以是与治疗剂缀合的香叶醇，例如化学治疗剂。 可用于本发明的化学治疗剂包括DNA烷化剂，拓扑异构酶抑制剂，内质网应激诱导剂，铂化合物，抗代谢物，酶抑制剂和受体拮抗剂。

公开(公告)号：US20160113924A1

公开(公告)日：2016-04-28

申请号：US14923896

申请日：2015-10-27

Applicant: NEONC Technologies, Inc.

Inventor： Thomas CHEN

IPC: A61K31/495 ,  A61K45/06 ,  A61M31/00 ,  A61M11/00 ,  A61M13/00 ,  A61M16/14 ,  A61K9/00 ,  A61M15/00

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0073 ,  A61K45/06 ,  A61K47/542 ,  A61M15/009 ,  A61M15/08

Abstract: A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).

Abstract translation: 在哺乳动物中治疗鼻咽癌的方法包括向哺乳动物递送治疗有效量的与替莫唑胺（TMZ）缀合的紫苏醇的邻苯二甲酸（POH）氨基甲酸酯。

公开(公告)号：US20230405125A1

公开(公告)日：2023-12-21

申请号：US18251839

申请日：2021-11-12

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas C. CHEN

IPC: A61K47/10 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K47/10 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides an intranasal glioblastoma therapy with purified perillyl alcohol. Patients with recurrent glioblastoma when treated with perillyl alcohol purified by the disclosed methods showed improved survival when compared to historical controls. Glioblastoma patients with an isocitrate dehydrogenase 1 (IDH1)-mutation showed improved survival when compared with wild-type IDH patients.

公开(公告)号：US20210283127A1

公开(公告)日：2021-09-16

申请号：US17313258

申请日：2021-05-06

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: A61K31/495 ,  A61K31/415 ,  A61K47/54 ,  A61K45/06 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00 ,  C07C33/14 ,  A61K9/00

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20210244820A1

公开(公告)日：2021-08-12

申请号：US17251452

申请日：2019-06-17

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: A61K47/54 ,  A61K47/10 ,  A61K47/55 ,  A61P29/00 ,  A61K9/08 ,  A61K9/00

Abstract: The present invention provides a method for treating inflammation in a mammal. The method includes delivering to the mammal a therapeutically effective amount of a composition including a perillyl alcohol (POH) conjugated with linoleic acid.

公开(公告)号：US11013804B2

公开(公告)日：2021-05-25

申请号：US16388535

申请日：2019-04-18

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K45/06 ,  A61K31/4015 ,  A61K9/00 ,  A61K31/415 ,  C07D487/04 ,  C07D231/12 ,  C07D207/26 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10

Abstract: The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.

公开(公告)号：US20200277299A1

公开(公告)日：2020-09-03

申请号：US16876621

申请日：2020-05-18

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish Puppali

IPC: C07D487/04 ,  A61P35/00 ,  C07D231/12

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

公开(公告)号：US20200237697A1

公开(公告)日：2020-07-30

申请号：US16606520

申请日：2018-04-18

Applicant: NEONC TECHNOLOGIES, INC.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPALLI

IPC: A61K31/20 ,  A61K47/55 ,  A61K45/06 ,  A61K9/00 ,  A61K31/045

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.