公开(公告)号：US11077104B2

公开(公告)日：2021-08-03

申请号：US16123729

申请日：2018-09-06

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K31/495 ,  A61K31/415 ,  A61K47/54 ,  A61K45/06 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00 ,  C07C33/14 ,  A61K9/00

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US09700524B2

公开(公告)日：2017-07-11

申请号：US15040002

申请日：2016-02-10

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US09657026B2

公开(公告)日：2017-05-23

申请号：US15192126

申请日：2016-06-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07D487/04 ,  C07D231/12

CPC classification number: C07D487/04 ,  C07D231/12

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

公开(公告)号：US20160039731A1

公开(公告)日：2016-02-11

申请号：US14359366

申请日：2012-11-21

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07C33/14 ,  A61K31/4188 ,  A61K31/4015 ,  A61N5/10 ,  A61K31/415 ,  A61K45/06 ,  C07B59/00 ,  A61K47/48 ,  A61K31/045

CPC classification number: A61K31/495 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C33/14 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention, provides for a deuterium-enriched monoterpene or sesquiterpene such as perillyl alcohol, or a deuterium-enriched isomer or analog of monoterpenes or sesquiterpenes, such as isoperillyl alcohol. The present invention also provides for a deuterium-enriched derivative of a monoterpene or sesquiterpene, such as a perillyl alcohol carbamate or a deuterium-enriched derivative of an isomer or analog of a monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The deuterium-enriched derivative may be perillyl alcohol or isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a deuterium-enriched compound.

Abstract translation: 本发明提供富含氘的单萜或倍半萜如香叶醇，或氘富含异构体或单萜或倍半萜类似物，如异戊醇。 本发明还提供了单萜或倍半萜的富氘代衍生物，如苝基氨基甲酸酯或单萜或倍半萜的异构体或类似物的氘富集衍生物，例如异戊醇醇氨基甲酸酯。 富含氘的衍生物可以是与诸如化学治疗剂的治疗剂缀合的紫苏醇或异环戊醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的富含氘化合物的步骤。

公开(公告)号：US20160038600A1

公开(公告)日：2016-02-11

申请号：US14595865

申请日：2015-01-13

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K47/48 ,  A61N5/10 ,  A61K45/06 ,  A61K31/4015 ,  A61K9/00

CPC classification number: A61K45/06 ,  A61K9/0043 ,  A61K31/4015 ,  A61K31/415 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.

Abstract translation: 本发明提供了诸如POH-Rolipram的珀维醇（POH）氨基甲酸酯。 本发明还提供了通过向患者递送治疗有效量的POH-咯利普兰来治疗疾病如癌症的方法。

公开(公告)号：US20150359754A1

公开(公告)日：2015-12-17

申请号：US14833210

申请日：2015-08-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas CHEN ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

IPC: A61K31/045 ,  A61N5/10 ,  A61K47/48 ,  A61K45/06 ,  A61K31/325

CPC classification number: A61K31/045 ,  A61K31/05 ,  A61K31/165 ,  A61K31/325 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07B2200/07 ,  C07C271/22 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K2300/00

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。 本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。 衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。 给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

公开(公告)号：US20140364472A1

公开(公告)日：2014-12-11

申请号：US14455371

申请日：2014-08-08

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K47/48 ,  A61K31/495 ,  A61N5/10 ,  A61K45/06

CPC classification number: C07C33/14 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。 例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。 紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。 给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

公开(公告)号：US11970436B2

公开(公告)日：2024-04-30

申请号：US17749293

申请日：2022-05-20

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07B2200/07 ,  C07C2601/16 ,  C07C29/92 ,  C07C33/14 ,  C07C201/12 ,  C07C205/57 ,  C07C67/14 ,  C07C69/76 ,  C07C67/14 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US20180155347A1

公开(公告)日：2018-06-07

申请号：US15646682

申请日：2017-07-11

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07D487/04 ,  C07D231/12

CPC classification number: C07D487/04 ,  A61P35/00 ,  C07D231/12

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

公开(公告)号：US09987237B2

公开(公告)日：2018-06-05

申请号：US14833210

申请日：2015-08-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

IPC: C07D487/04 ,  A61K31/4188 ,  A61P35/00 ,  A61K31/045 ,  A61K31/05 ,  A61K45/06 ,  A61K31/165 ,  A61K47/48 ,  A61K31/415 ,  A61K31/4015 ,  A61K31/325 ,  A61N5/10 ,  C07C271/22 ,  C07D231/12 ,  C07D207/26

CPC classification number: A61K31/045 ,  A61K31/05 ,  A61K31/165 ,  A61K31/325 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07B2200/07 ,  C07C271/22 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K2300/00

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.