公开(公告)号：US20160018391A1

公开(公告)日：2016-01-21

申请号：US14774002

申请日：2014-03-10

Applicant: SHARP KABUSHIKI KAISHA ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Mugihei IKEMIZU ,  Shiho TOKONAMI ,  Hiroshi SHIIGI ,  Tsutomu NAGAOKA

IPC: G01N33/543 ,  C25D5/34 ,  C25D5/48 ,  G01N33/569

CPC classification number: G01N33/5438 ,  C12M41/36 ,  C12Q1/04 ,  C25D5/34 ,  C25D5/48 ,  G01N33/569 ,  G01N2600/00

Abstract: The present invention is a sensor for detecting a microorganism, which is provided with a detection unit equipped with a detection electrode and a polymer layer, wherein the polymer layer is arranged on the detection electrode and is provided with a template having a three-dimensional structure complementary to a three-dimensional structure of a microorganism to be detected. The sensor detects a microorganism on the basis of the captured state of the microorganism onto the template. The polymer layer is formed by a manufacturing method including a polymerization step of polymerizing a monomer in the presence of the microorganism to be detected to form a polymer layer having the microorganism incorporated therein on the detection electrode, and a disruption step of bringing at least a part of the microorganism incorporated in the polymer layer into contact with a solution containing a lytic enzyme to disrupt the microorganism.

Abstract translation: 本发明是一种用于检测微生物的传感器，其具有配备有检测电极和聚合物层的检测单元，其中聚合物层布置在检测电极上并且具有三维结构的模板 与待检测的微生物的三维结构互补。 传感器根据微生物的捕获状态将微生物检测到模板上。 聚合物层通过包括聚合步骤的方法形成，所述聚合步骤在待检测的微生物存在下聚合单体以在检测电极上形成其中包含微生物的聚合物层，以及至少使 引入到聚合物层中的微生物的一部分与含有裂解酶的溶液接触以破坏微生物。

公开(公告)号：US09188735B2

公开(公告)日：2015-11-17

申请号：US13887860

申请日：2013-05-06

Applicant: FUJIKURA LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Ryo Maruyama ,  Nobuo Kuwaki ,  Shoichiro Matsuo ,  Masaharu Ohashi

IPC: G02B6/02 ,  G02B6/036

CPC classification number: G02B6/02 ,  G02B6/02019 ,  G02B6/03627

Abstract: An optical fiber (1) includes (i) an inner core (111) whose refractive index distribution has an α profile, (ii) an outer core (112) which surrounds the inner core (111), and (iii) a clad (12) which surrounds the outer core (112). In the optical fiber (1), Rd is set to not less than 0.15, where Rd is a ratio of a refractive index difference between the outer core (112) and the clad (12) to a refractive index difference between a center part of the inner core (111) and the clad (12).

Abstract translation: 光纤（1）包括（i）其折射率分布具有α轮廓的内芯（111），（ii）围绕内芯（111）的外芯（112），以及（iii）包层 12）围绕外芯（112）。 在光纤（1）中，Rd被设定为不小于0.15，其中Rd是外芯（112）和包层（12）之间的折射率差之比与中心部分之间的折射率差 内芯（111）和包层（12）。

公开(公告)号：US20150183831A1

公开(公告)日：2015-07-02

申请号：US14377748

申请日：2013-02-07

Applicant: STELLA PHARMA CORPORATION ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Mitsunori Kirihata ,  Kohki Uehara

IPC: C07K11/02 ,  C07K11/00

CPC classification number: C07K11/02 ,  C07C229/08 ,  C07C229/24 ,  C07C235/12 ,  C07C237/12 ,  C07D273/00 ,  C07K11/00 ,  C07K14/32

Abstract: The purpose of the present invention is to provide a novel method for producing cereulide and a derivative thereof; an intermediate for cereulide; and a novel cereulide derivative. A novel didepsipeptide, a novel tetradepsipeptide, a novel octadepsipeptide and a novel dodecadepsipeptide are prepared. A linear precursor of cereulide or a derivative thereof, which is composed of any one of the novel depsipeptides, is cyclized by forming an intramolecular amide bond.

Abstract translation: 本发明的目的是提供一种制备大戟素及其衍生物的新方法; 大众中间物 和一种新型的cereulide衍生物。 制备了一种新型的七叶皂苷肽，一种新型的四肽类，一种新的十八肽和一种新的十二十一生物肽。 通过形成分子内酰胺键将由任何一种新的缩肽组成的大脑或其衍生物的线性前体环化。

公开(公告)号：US20140029901A1

公开(公告)日：2014-01-30

申请号：US13948664

申请日：2013-07-23

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION ,  FUJIKURA LTD.

Inventor： Ryo Maruyama ,  Nobuo Kuwaki ,  Shoichiro Matsuo ,  Masaharu Ohashi

IPC: G02B6/028 ,  G02B6/44

CPC classification number: G02B6/0281 ,  G02B6/02047 ,  G02B6/02214 ,  G02B6/03627 ,  G02B6/4401

Abstract: An optical fiber, including (i) an inner core having an α-power refractive index profile, (ii) an outer core having a refractive index of n1′, and (iii) a cladding having a refractive index of n2 (n1′

Abstract translation: 一种光纤，包括（i）具有α-功率折射率分布的内芯，（ii）折射率为n1'的外芯，以及（iii）折射率为n2（n1' n2

公开(公告)号：US11324831B2

公开(公告)日：2022-05-10

申请号：US15585228

申请日：2017-05-03

Applicant: TOAGOSEI CO., LTD ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Ikuhiko Nakase ,  Tetsuhiko Yoshida ,  Nahoko Baileykobayashi

IPC: A61K47/46 ,  A61K38/18 ,  A61P35/00 ,  A61P43/00 ,  A61K9/50

Abstract: Provided is a novel material used to introduce an exogenous substance into cells. Also provided is a method for introducing an exogenous substance into target cells using this material. The present invention provides an exosome that is used to introduce an exogenous substance into target cells, wherein the exosome contains one type or two or more types of an exogenous substance and a substance that induces macropinocytosis in the target cells. The present invention also provides a composition containing the exosome and a method for introducing an exogenous substance into cells using this exosome.

公开(公告)号：US20190239793A1

公开(公告)日：2019-08-08

申请号：US16333285

申请日：2017-01-26

Applicant: Sharp Kabushiki Kaisha ,  Osaka Prefecture University Public Corporation

Inventor： Tetsuya HAYASHI ,  Hiroshi SAKAYA ,  Azusa NAKANO ,  Syunsuke SHIMAMURA ,  Terumasa SHIMADA

IPC: A61B5/16 ,  A61B5/044 ,  A61B5/0468 ,  A61B5/00

CPC classification number: A61B5/165 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/7235 ,  A61B2503/40

Abstract: A state acquisition computer is provided that includes an interface configured to acquire data for indicating an inter-beat interval of an animal, and a processor configured to convert a Poincare plot of inter-beat intervals into a prescribed coordinate system, and based on a standard deviation of the Poincare plot after conversion, acquire information indicating a psychological state or a physical state of the animal.

公开(公告)号：US20190209073A1

公开(公告)日：2019-07-11

申请号：US16299405

申请日：2019-03-12

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION ,  EuSense Medical Co., Ltd. ,  HYOGO COLLEGE OF MEDICINE ,  J craft Co., Ltd.

Inventor： Michifumi Yoshioka ,  Katsufumi Inoue ,  Yoshitaka Oku

IPC: A61B5/00 ,  A61B5/08 ,  G06N20/10

CPC classification number: A61B5/4205 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/7257 ,  A61B5/7275 ,  A61B10/00 ,  G06N20/10

Abstract: A swallowing diagnosis apparatus includes a controller which enables a first swallowing determination process of determining whether or not there is an aspiration risk in the swallowing on the basis of respiratory phases before and after a period in which swallowing has been estimated as having occurred; and a second swallowing determination process of extracting reference information including at least one of the sound information and the respiration information in a predetermined period including the period in which swallowing has been estimated as having occurred, obtaining a feature quantity from the extracted reference information, and performing a machine learning process on the obtained feature quantity to determine whether or not there is a possibility of dysphagia in the swallowing; and a display control process of causing a determination result obtained by the first swallowing determination process and a determination result obtained by the second swallowing determination process to be displayed.

公开(公告)号：US10344042B2

公开(公告)日：2019-07-09

申请号：US15625909

申请日：2017-06-16

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： Hiroshi Takenaka ,  Yoichiro Ohta ,  Yusuke Taguchi ,  Sayuri Ueda ,  Yuko Ishino ,  Tomohiro Yoshikawa ,  Hideki Nakashima ,  Kohki Uehara ,  Mitsunori Kirihata

IPC: C07F5/02 ,  C07C271/22 ,  C07C229/36 ,  C07C251/24

Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N═N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C═N, in which NR40R50 are together.

公开(公告)号：US20180245191A1

公开(公告)日：2018-08-30

申请号：US15901941

申请日：2018-02-22

Applicant: HONDA MOTOR CO., LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Kazuki Nagao ,  Yusuke Kikuchi ,  Masahiro Hayashi ,  Takayuki Takasugi ,  Yasuyuki Kaneno

IPC: C22F1/10 ,  C22C19/03 ,  C22C1/02

Abstract: There is provided a Ni-based intermetallic alloy having a dual multi-phase microstructure containing a primary precipitate L12 phase and an (L12+D022) eutectoid microstructure. Thus, the Ni-based intermetallic alloy contains Ni, Al, and V as basic elements, and the contents of Ni, Al, and V are controlled to form the dual multi-phase microstructure. The Ni-based intermetallic alloy further contains at least one of Zr and Hf in addition to the basic elements.

公开(公告)号：US10005794B2

公开(公告)日：2018-06-26

申请号：US15105401

申请日：2014-12-16

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： Hiroshi Takenaka ,  Yoichiro Ohta ,  Yusuke Taguchi ,  Sayuri Ueda ,  Yuko Ishino ,  Tomohiro Yoshikawa ,  Hideki Nakashima ,  Kohki Uehara ,  Mitsunori Kirihata

IPC: C07F5/02 ,  C07C271/22 ,  C07C229/36 ,  C07C251/24

CPC classification number: C07F5/027 ,  C07C229/36 ,  C07C251/24 ,  C07C271/22 ,  Y02P20/55

Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N═N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C═N, wherein NR40R50 are together.)