公开(公告)号：US07745439B2

公开(公告)日：2010-06-29

申请号：US10599913

申请日：2005-04-12

Applicant: Hyae Gyeong Cheon ,  Sung-Eun Yoo ,  Sung Soo Kim ,  Sung-Don Yang ,  Kwang-Rok Kim ,  Sang Dal Rhee ,  Jin Hee Ahn ,  Seung Kyu Kang ,  Won Hoon Jung ,  Sung Dae Park ,  Nam Gee Kim ,  Sun Mee Kim ,  Kil Woong Mo ,  Jae Mok Lee ,  Hye Jung Kang ,  Koun Ho Lee ,  Jong Hoon Kim ,  Jeong-Hyung Lee ,  Seung Jun Kim

Inventor： Hyae Gyeong Cheon ,  Sung-Eun Yoo ,  Sung Soo Kim ,  Sung-Don Yang ,  Kwang-Rok Kim ,  Sang Dal Rhee ,  Jin Hee Ahn ,  Seung Kyu Kang ,  Won Hoon Jung ,  Sung Dae Park ,  Nam Gee Kim ,  Sun Mee Kim ,  Kil Woong Mo ,  Jae Mok Lee ,  Hye Jung Kang ,  Koun Ho Lee ,  Jong Hoon Kim ,  Jeong-Hyung Lee ,  Seung Jun Kim

IPC: A61K31/216 ,  A61K31/4402 ,  A61K31/5375 ,  C07C69/753 ,  C07D211/70 ,  C07D265/32

CPC classification number: C07D295/088 ,  C07C65/26 ,  C07C69/757 ,  C07C229/50 ,  C07C233/52 ,  C07C255/47 ,  C07C2601/14 ,  C07C2602/08 ,  C07D295/155

Abstract: The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

Abstract translation: 式（I）的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体（PPAR）的活性，不引起副作用，因此它们可用于治疗和预防由PPARs调节的病症， 糖尿病，肥胖，动脉硬化，高脂血症，高胰岛素血症和高血压等代谢综合征，骨质疏松症，肝硬化和哮喘等炎性疾病和癌症。

公开(公告)号：US07414068B2

公开(公告)日：2008-08-19

申请号：US10510835

申请日：2003-04-10

Applicant: Hong Lim ,  Dong-Ha Lee ,  Sun-Ok Kim ,  In-Young Choi ,  Sung-Eun Yoo ,  Kyu-Yang Yi ,  Sun-Kyung Lee ,  Jee-Hee Suh ,  Nak-Jeong Kim ,  Byung-Ho Lee ,  Ho-Won Seo ,  Hwa-Sup Shin

Inventor： Hong Lim ,  Dong-Ha Lee ,  Sun-Ok Kim ,  In-Young Choi ,  Sung-Eun Yoo ,  Kyu-Yang Yi ,  Sun-Kyung Lee ,  Jee-Hee Suh ,  Nak-Jeong Kim ,  Byung-Ho Lee ,  Ho-Won Seo ,  Hwa-Sup Shin

IPC: A61K31/41 ,  C07D257/04

CPC classification number: C07D405/12

Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.

Abstract translation: 本发明涉及用包括四唑的仲胺取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物。 本发明的化合物可用于保护神经细胞和脑损伤; 抗氧化; 抑制NO产生; 保护心脏 抑制血管发生; 保护肾脏，心脏和组织等保护器官，并在主要心血管手术中保护器官。

公开(公告)号：US06908942B2

公开(公告)日：2005-06-21

申请号：US10461433

申请日：2003-06-16

Applicant: Young-Dae Gong ,  Jin-Soo Seo ,  Jong Yeon Hwang ,  Sung-eun Yoo

Inventor： Young-Dae Gong ,  Jin-Soo Seo ,  Jong Yeon Hwang ,  Sung-eun Yoo

IPC: C07D311/70 ,  A61K31/353 ,  A61K31/381 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00 ,  C07D311/22 ,  C07D407/12 ,  C07D409/12 ,  A61K31/35 ,  C07D311/76

CPC classification number: C07D407/12 ,  C07D311/22 ,  C07D409/12

Abstract: The present invention provides (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing benzopyran derivatives with high efficiency by parallel synthesis on a solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products.

Abstract translation: 本发明提供（i）6-氨基-2,2-二甲基-3,4,6-三取代的苯并吡喃衍生物; （ii）通过作为组合化学合成技术之一的固相上的并行合成来高效合成苯并吡喃衍生物的方法; 和（iii）苯并吡喃衍生物用于预防和治疗通过促进脂质过氧化或氧化产物积累而引起的疾病或病症的用途。

公开(公告)号：US4450172A

公开(公告)日：1984-05-22

申请号：US356712

申请日：1982-03-10

Applicant: Sung-eun Yoo

Inventor： Sung-eun Yoo

IPC: A61K31/235 ,  C07C69/612 ,  C07C69/618

CPC classification number: A61K31/235 ,  C07C69/612

Abstract: Polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols, such as 2-(4-((2-hydroxy-3-(1-methylethylamino)-phenyl)ethyl 3-(4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl))benzene propanoate, are useful as antihypertensive agents. Preferred compounds give vasodilatory activity and reduced tachycardia.

Abstract translation: 多卤代羟基异丙基苯基烷基（e）烷基氨基羟基丙氧基苯基烷基醇的酸性酯，例如2-（4 - （（2-羟基-3-（1-甲基乙基氨基） - 苯基）乙基3-（4-（2,2,2-三氟 - 1-羟基-1-三氟甲基乙基））苯丙酸酯，可用作抗高血压剂。优选的化合物具有血管舒张活性和降低的心动过速。