公开(公告)号：US20150094353A1

公开(公告)日：2015-04-02

申请号：US14496384

申请日：2014-09-25

申请人： Jian-Ting Zhang

发明人： Jian-Ting Zhang

IPC分类号： C07D207/44

CPC分类号： C07D207/44 ,  A61K31/402

摘要： The present invention provides STAT3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit STAT3 binding to DNA without affecting the activation and dimerization of STAT3. Furthermore, the inhibitors of the present invention inhibit expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.

摘要翻译： 本发明提供优先抑制癌细胞增殖的STAT3抑制剂，并抑制恶性细胞的迁移和侵袭。 本发明的抑制剂选择性抑制STAT3与DNA的结合，而不影响STAT3的活化和二聚化。 此外，本发明的抑制剂抑制STAT3下游靶基因和STAT3原位结合染色质的表达。

公开(公告)号：US20140301858A1

公开(公告)日：2014-10-09

申请号：US14238626

申请日：2012-07-11

申请人： Feng Lin ,  Renji Zhang ,  Qianming Gong ,  Lei Zhang ,  Ting Zhang ,  Xiao Yuan ,  Wentao Yan

发明人： Feng Lin ,  Renji Zhang ,  Qianming Gong ,  Lei Zhang ,  Ting Zhang ,  Xiao Yuan ,  Wentao Yan

IPC分类号： F01D5/28

CPC分类号： F01D5/282 ,  F01D5/225 ,  F01D5/288 ,  F01D5/34 ,  F05D2300/603 ,  Y02T50/672 ,  Y02T50/673

摘要： Disclosed is a turbine rotor device for a gas turbine, the turbine rotor device comprising a turbine rotor body, and a pre-stressed fiber-wound layer, wherein the pre-stressed fiber-wound layer is wound on the periphery of the turbine rotor body to exert a predetermined pre-loading force on the turbine rotor body. Additionally, a rotor, and a gas turbine and a turbine engine having the turbine rotor device are also provided.

摘要翻译： 公开了一种用于燃气轮机的涡轮转子装置，该涡轮转子装置包括一涡轮转子体和一预应力纤维缠绕层，其中预应力纤维缠绕层缠绕在涡轮转子体的周边 以对涡轮转子体施加预定的预加载力。 此外，还提供了具有涡轮转子装置的转子，燃气轮机和涡轮发动机。

公开(公告)号：US08362701B2

公开(公告)日：2013-01-29

申请号：US12548793

申请日：2009-08-27

申请人： Gang Yao ,  Bo Zhang ,  Fanbin Fabio Wang ,  Xuefei Xie ,  Ting Zhang ,  Peng Sun

发明人： Gang Yao ,  Bo Zhang ,  Fanbin Fabio Wang ,  Xuefei Xie ,  Ting Zhang ,  Peng Sun

IPC分类号： H05B41/36

CPC分类号： H05B41/2985 ,  H05B41/2988

摘要： Ballasts are presented with improved end-of-life (EOL) detection of lamp DC voltage components and protection circuits to facilitate user maintenance and extend lamp life using selective dimming with preheating when EOL conditions are detected.

摘要翻译： 镇流器具有改进的寿命终止（EOL）检测灯直流电压元件和保护电路，以便在检测到EOL条件时使用预热进行选择性调光，从而方便用户维护和延长灯泡使用寿命。

公开(公告)号：US08243438B2

公开(公告)日：2012-08-14

申请号：US12127021

申请日：2008-05-27

申请人： He-Li Wang ,  Hong Li ,  Ting Zhang ,  Ting-Ting Zhao

发明人： He-Li Wang ,  Hong Li ,  Ting Zhang ,  Ting-Ting Zhao

IPC分类号： H05K5/00 ,  H05K7/00

CPC分类号： G06F1/1677 ,  G06F1/1616 ,  G06F1/3203 ,  Y10T292/1029

摘要： An electronic apparatus (10) includes a main body (30), a lid (20) pivotably connected with a side of the main body, a magnetic detecting unit (40) and a magnetic shield member (28). The detecting unit includes a magnetic body (42) mounted on one of the main body or the lid and a magnetic detector (44) mounted on the other one of the main body or the lid, respectively. The magnetic body has a facing side (421) to face the magnetic detector. The magnetic detector detects a position of the lid according to a magnetic field intensity of the magnetic body. The magnetic shield member is disposed at a distance from the facing side and adjacent to a second side (422) of the magnetic body, to prevent the magnetic field from extending in the direction of the second side of the magnetic body.

摘要翻译： 电子设备（10）包括主体（30），与主体一侧可枢转地连接的盖（20），磁检测单元（40）和磁屏蔽构件（28）。 检测单元包括安装在主体或盖中的一个上的磁体（42）和分别安装在主体或盖的另一个上的磁检测器（44）。 磁体具有面对磁检测器的面对侧（421）。 磁检测器根据磁体的磁场强度检测盖的位置。 磁屏蔽构件配置在与磁体的第二侧（422）相邻的一侧的距离处，以防止磁场沿着磁体的第二侧的方向延伸。

公开(公告)号：US20120002447A1

公开(公告)日：2012-01-05

申请号：US12893584

申请日：2010-09-29

申请人： Gang Yao ,  Bo Zhang ,  Ting Zhang

发明人： Gang Yao ,  Bo Zhang ,  Ting Zhang

IPC分类号： H02M3/335

CPC分类号： H02M3/155 ,  H02M1/08 ,  H02M1/36 ,  H02M1/40 ,  H03K17/691

摘要： A high side isolated gate drive controller circuit is presented with an on-time limiting circuit to prevent isolation transformer saturation as well as a universal power up circuit adaptable to power the driver with constant voltage for different input voltage levels.

摘要翻译： 高侧隔离栅极驱动控制器电路具有导通时间限制电路，以防止隔离变压器饱和，以及通用上电电路，适用于为不同输入电压电平的恒定电源为驱动器供电。

公开(公告)号：US20110144359A1

公开(公告)日：2011-06-16

申请号：US12970131

申请日：2010-12-16

申请人： Evert VAN DER HEIDE ,  Ting Zhang

发明人： Evert VAN DER HEIDE ,  Ting Zhang

IPC分类号： C07D307/48

CPC分类号： C07D307/48 ,  C07D307/50

摘要： A method for producing furfural from lignocellulosic biomass material is provided, comprising (a) contacting the lignocellulosic biomass material with a mixture comprising water and an organic acid at a temperature of at least 100° C. and a pressure of at most 10 bar (absolute) to obtain a first liquid stream comprising hydrolysed hemicellulose and a second stream comprising lignin and cellulose; (b) maintaining the first liquid stream comprising hydrolysed hemicellulose at a temperature of at least 130° C. to obtain a second liquid stream comprising furfural; and (c) separating the furfural obtained in step b) from the second liquid stream.

摘要翻译： 提供了一种从木质纤维素生物质材料生产糠醛的方法，包括（a）在至少100℃的温度和至多10巴的压力（绝对值）下使木质纤维素生物质材料与包含水和有机酸的混合物接触 ）以获得包含水解的半纤维素的第一液体流和包含木质素和纤维素的第二料流; （b）在至少130℃的温度下保持包含水解的半纤维素的第一液体流，以获得包含糠醛的第二液体流; 和（c）将步骤b）中获得的糠醛与第二液体流分离。

公开(公告)号：US10968210B2

公开(公告)日：2021-04-06

申请号：US16345913

申请日：2017-11-13

申请人： Merck Sharp & Dohme Corp. ,  Thomas J. Greshock ,  James Mulhearn ,  Anthony J. Roecker ,  Tianying Jian ,  Gang Zhou ,  Liangqin Guo ,  Walter Won ,  Ting Zhang ,  Rajan Anand ,  John E. Stelmach ,  Deping Wang ,  Ronald M. Kim ,  Mark E. Layton ,  Christopher S. Burgey ,  Philippe G. Nantermet

发明人： Thomas J. Greshock ,  James Mulhearn ,  Anthony J. Roecker ,  Tianying Jian ,  Gang Zhou ,  Liangqin Guo ,  Walter Won ,  Ting Zhang ,  Rajan Anand ,  John E. Stelmach ,  Deping Wang ,  Ronald M. Kim ,  Mark E. Layton ,  Christopher S. Burgey ,  Philippe G. Nantermet

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D277/52 ,  C07D471/04 ,  C07D487/10 ,  C07D401/12 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08

摘要： Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.

公开(公告)号：US10519147B2

公开(公告)日：2019-12-31

申请号：US16061815

申请日：2016-12-15

申请人： Merck Sharp & Dohme Corp. ,  Thomas J. Greshock ,  James Mulhearn ,  Liangqin Guo ,  Ting Zhang ,  Deping Wang ,  Ronald M. Kim ,  Mark E. Layton ,  Michael J. Kelly, III ,  Rajan Anand ,  Philippe Nantermet ,  Tianying Jian ,  Anthony J. Roecker ,  Walter Won ,  Gang Zhou

发明人： Thomas J. Greshock ,  James Mulhearn ,  Liangqin Guo ,  Ting Zhang ,  Deping Wang ,  Ronald M. Kim ,  Mark E. Layton ,  Michael J. Kelly, III ,  Rajan Anand ,  Philippe Nantermet ,  Tianying Jian ,  Anthony J. Roecker ,  Walter Won ,  Gang Zhou

IPC分类号： C07D417/12 ,  A61K45/06 ,  C07D277/52 ,  C07D285/135 ,  A61P25/02 ,  A61P25/04 ,  A61P11/14 ,  A61P17/04

摘要： Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.

公开(公告)号：US20180296557A1

公开(公告)日：2018-10-18

申请号：US15573867

申请日：2016-05-13

申请人： Jian-Ting Zhang ,  Jing-Yuan Liu

发明人： Jian-Ting Zhang ,  Jing-Yuan Liu

IPC分类号： A61K31/4985 ,  A61P35/02

CPC分类号： A61K31/4985 ,  A61P35/02 ,  G01N33/5011

摘要： Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure.

公开(公告)号：US09382204B2

公开(公告)日：2016-07-05

申请号：US14496384

申请日：2014-09-25

申请人： Jian-Ting Zhang

发明人： Jian-Ting Zhang

IPC分类号： C07D207/44

CPC分类号： C07D207/44 ,  A61K31/402

摘要： The present invention provides STAT3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit STAT3 binding to DNA without affecting the activation and dimerization of STAT3. Furthermore, the inhibitors of the present invention inhibit expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.

摘要翻译： 本发明提供优先抑制癌细胞增殖的STAT3抑制剂，并抑制恶性细胞的迁移和侵袭。 本发明的抑制剂选择性抑制STAT3与DNA的结合，而不影响STAT3的活化和二聚化。 此外，本发明的抑制剂抑制STAT3下游靶基因和STAT3原位结合染色质的表达。