Induced photodynamic therapy using nanoparticle scintillators as transducers

    公开(公告)号:US10646570B2

    公开(公告)日:2020-05-12

    申请号:US15320078

    申请日:2015-06-18

    IPC分类号: A61K41/00 A61N5/06 A61N5/10

    摘要: Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation, a photosensitizer which absorbs electromagnetic radiation of said first wavelength and a biocompatible mesoporous material are disclosed herein. In some examples, the photodynamic therapy system comprises a core comprising the nanoparticle, a first shell comprising the biocompatible mesoporous material, and a photosensitizer embedded in the first shell. Upon irradiation by, for example, X-rays, the nanoparticle can function as a transducer, converting X-ray photons to visible photons, and in turn, activating the photosensitizers. Methods of using the photodynamic therapy system are also disclosed.

    AVIAN REOVIRUS VACCINES
    44.
    发明申请

    公开(公告)号:US20200069788A1

    公开(公告)日:2020-03-05

    申请号:US16683479

    申请日:2019-11-14

    发明人: Holly S. Sellers

    摘要: The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the southeast United States. The invention is directed to these novel group 1 and group 2 avian reoviruses, diagnostic assays using antibodies and/or nucleotide- or amino acid-specific components of such viruses, such as the S1 gene encoding the sigma C protein, and to vaccines that protect chickens from disease caused by such viruses.