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公开(公告)号：US20240000946A1
公开(公告)日：2024-01-04
申请号：US18039644
申请日：2021-12-03
申请人： VILNIUS UNIVERSITY
发明人： Daumantas MATULIS , Audrius ZAKSAUSKAS , Asta ZUBRIENE , Lina BARANAUSKIENE , Jurgita MATULIENE , Virginija DUDUTIENE , Edita CAPKAUSKAITE , Vaida PAKETURYTE , Joana SMIRNOVIENE
摘要： This invention relates to a field of novel multi-headed compounds capable of binding and inhibiting the catalytic activity of human carbonic anhydrases for diagnostic, visualization, and treatment purposes. A series of compounds containing two or more of carbonic anhydrase inhibitors are linked together via short or long linker molecular moieties. Such dimeric or multimeric inhibitors are designed in such a way that one inhibitor molecule is able to reach several CA IX molecules on the surface of cancer cells. Such compounds are expected to have a significantly more powerful therapeutic effect and may be used for various strategies of specific compound deliveries to the desired site.
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公开(公告)号：US20240000736A1
公开(公告)日：2024-01-04
申请号：US17948251
申请日：2022-09-20
申请人： Vilnius University
发明人： Daumantas Matulis , Andrius Sakalauskas , Virginija Dudutiene , Mantas Zvirblis , Mantas Ziaunys , Vytautas Smirnovas
IPC分类号： A61K31/196 , A61K31/195 , A61K31/18 , A61K31/63 , A61P25/28
CPC分类号： A61K31/196 , A61K31/195 , A61K31/18 , A61K31/63 , A61P25/28
摘要： This invention teaches a class of fluorinated benzensulfonamides of general structure I, as shown:
which are useful for inhibiting protein amyloid aggregation. The compounds taught can be used in pharmaceutical compositions in effective amounts to treat illnesses that result from protein amyloid aggregation.-
公开(公告)号：US20230123754A1
公开(公告)日：2023-04-20
申请号：US17857480
申请日：2022-07-05
申请人： Vilnius University
IPC分类号： C12N15/113 , C12N15/10 , C12Q1/6811 , C12P19/34 , C12N9/22 , C12N15/90
摘要： Isolation or in vitro assembly of the Cas9-crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system and use for cleavage of DNA bearing a nucleotide sequence complementary to the crRNA and a proto-spacer adjacent motif. Methods for site-specific modification of a target DNA molecule using an RNA-guided DNA endonuclease comprising at least one RNA sequence and at least one of an RuvC active site motif and an HNH active site motif; for conversion of Cas9 polypeptide into a nickase cleaving one strand of double-stranded DNA by inactivating one of the active sites (RuvC or HNH) in the polypeptide by at least one point mutation; for assembly of active polypeptide-polyribonucleotides complex in vivo or in vitro; and for re-programming a Cas9-crRNA complex specificity in vitro or using a cassette containing a single repeat-spacer-repeat unit.
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公开(公告)号：US11566214B2
公开(公告)日：2023-01-31
申请号：US16792484
申请日：2020-02-17
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , President and Fellows of Harvard College , Vilnius University
摘要： Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels.
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公开(公告)号：US20220367007A1
公开(公告)日：2022-11-17
申请号：US17642836
申请日：2019-09-10
摘要： The invention generally relates to the field of protein sequences and of generation of functional protein sequences. More particularly, the invention concerns a method for generating functional protein sequences with generative adversarial networks. The described method for functional sequence generation comprises plurality of steps, each of which is crucial to ensure the high percentage of functional sequences in the final sequence set: selecting a plurality of existing protein sequences to define the approximate sequence space for the later generated synthetic sequences, processing the selected protein sequences, approximating the unknown true distribution of amino acids of the pre-processed sequences using a variation of generative adversarial networks, obtaining protein sequences from the approximated distribution, processing of the obtained protein sequences. The described method provides a resource (e.g. time, cost) efficient way of producing synthetic protein sequences which have a high probability of being functional experimentally.
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公开(公告)号：US20220138955A1
公开(公告)日：2022-05-05
申请号：US17600614
申请日：2020-04-09
申请人： Vilnius University
发明人： Arvydas Laurinavicius , Allan Rasmusson , Ausrine Nestarenkaite , Dovile Zilenaite , Renaldas Augulis
摘要： We present a new method to automatically sample the tumour/stroma interface zone (IZ) from microscopy image analysis data. It first delineates the tumour edge using a set of explicit rules in grid-subsampled tissue areas; then the IZ of controlled width is sampled and ranked by the distance from the edge to compute TIL density profiles across the IZ. From this data, a set of novel Immunogradient indicators are computed to reflect TIL “gravitation” towards the tumour. We applied the method on CD8 immunohistochemistry images of surgically excised breast and colorectal cancers to predict overall patient survival. In both patient cohorts, we found strong and independent prognostic value of the Immunogradient indicators, outperforming methods currently available. We conclude that data-driven, automated, human operator-independent IZ sampling enables precise spatial immune response measurement in the tumour/host interaction frontline for prediction of disease and therapy outcomes.
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公开(公告)号：US11312682B2
公开(公告)日：2022-04-26
申请号：US15748559
申请日：2015-09-01
申请人： VILNIUS UNIVERSITY
IPC分类号： C07C311/16 , C07D215/08 , C07D235/08 , C07D233/58 , C07D209/08 , C07C321/28 , C07D265/30 , C07C317/40 , A61P3/04 , A61P25/18 , A61P25/08 , A61P35/00
摘要： Disclosed are novel compounds—benzenesulfonamides of general formulas (I) and (II) The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression. Also disclosed are method of treatment using such compounds.
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公开(公告)号：US20220015683A1
公开(公告)日：2022-01-20
申请号：US17295469
申请日：2019-11-21
发明人： Vaidotas Marozas , Andrius Petrenas , Andrius Solosenko , Saulius Daukantas , Monika Simaityte , Andrius Rapalis , Justinas Bacevicius , Audrius Aidietis
摘要： The system and method defined herein are intended to detect, monitor and characterize in a non-invasive way cardiac arrhythmias of a patient that are associated with the development of atrial arrhythmia and increased risk of ischemic cerebral stroke. The system consists of a portable device with integrated sensors for biosignals; integrated modules in the portable device for recognition of intermittent atrial arrhythmia episodes; a module for characterization of the distribution of atrial arrhythmia episodes aiming to assess disease progression. The proposed is a technical solution allows for long-term monitoring of atrial fibrillation in a non-invasive way for the patient. If a non-documented atrial arrhythmia is detected by automatic means during the long-term monitoring, a physician is informed by e-mail by sending the electrocardiogram of the said arrhythmia episode. If the physician confirms diagnosis of atrial fibrillation, a recommendation for immediate medical attention is sent to patient's smart device.
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公开(公告)号：US11008605B2
公开(公告)日：2021-05-18
申请号：US15559689
申请日：2016-03-18
申请人： VILNIUS UNIVERSITY
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6853 , C12Q1/6876
摘要： Provided is a method for modifying a ssRNA at the 3′ end, the method including contacting the strand with a ssRNA 2′-O-methyltransferase in the presence of a co-factor, under conditions which allow for the transfer by the ssRNA 2′-O-methyltransferase of a part of the co-factor onto the 3′ end of the ssRNA to form a modified ssRNA, wherein the ssRNA bears 2′-OH group at 3′ terminal nucleotide and wherein the part of the co-factor transferred includes a reporter group or a functional group.
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公开(公告)号：US20200316597A1
公开(公告)日：2020-10-08
申请号：US16904523
申请日：2020-06-17
申请人： The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Vilnius University
发明人： Joseph Italiano , Linas Mazutis , Jonathan Thon , David A. Weitz
摘要： A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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