公开(公告)号：US20110105530A1

公开(公告)日：2011-05-05

申请号：US13000413

申请日：2009-06-25

Applicant: Natalie Dales ,  Zaihui Zhang ,  Jianmin Fu ,  Duanjie Hou ,  Shaoyi Sun ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia

Inventor： Natalie Dales ,  Zaihui Zhang ,  Jianmin Fu ,  Duanjie Hou ,  Shaoyi Sun ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia

IPC: A61K31/4965 ,  C12N9/96 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/444 ,  C07D401/14 ,  C07D401/04 ,  A61P3/10 ,  A61P3/00 ,  C07D413/14 ,  A61K31/4709 ,  A61P17/02 ,  A61P17/00 ,  C07D211/72 ,  A61K31/44 ,  A61P3/04 ,  A61P17/10 ,  A61P17/06

CPC classification number: C07D213/81 ,  A61K31/4439 ,  A61K31/444 ,  C07D213/89 ,  C07D401/04 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract translation: 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。

公开(公告)号：US07829712B2

公开(公告)日：2010-11-09

申请号：US11575642

申请日：2005-09-20

Applicant: Rajender Kamboj ,  Zaihui Zhang ,  Jianmin Fu ,  Serguei Sviridov ,  Sultan Chowdhury ,  Vishnumurthy Kodumuru

Inventor： Rajender Kamboj ,  Zaihui Zhang ,  Jianmin Fu ,  Serguei Sviridov ,  Sultan Chowdhury ,  Vishnumurthy Kodumuru

IPC: C07D413/00 ,  C07D211/30 ,  C07D401/00 ,  A61K31/50 ,  A61K31/497 ,  A61K31/41 ,  A61K31/415

CPC classification number: C07D401/12 ,  A61K31/501 ,  C07D237/24 ,  C07D403/12

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物，其中x，y，G，J，K， L，M，Q，W，V，R2，R3，R5，R5a，R6，R6a，R7，R7a，R8和R8a。 还公开了包含式（I）化合物的药物组合物。

公开(公告)号：US07767677B2

公开(公告)日：2010-08-03

申请号：US11575640

申请日：2005-09-20

Applicant: Rajender Kamboj ,  Zaihui Zhang ,  Jianmin Fu ,  Vishnumurthy Kodumuru ,  Serguei Sviridov ,  Kashinath Sadalapure ,  Shifeng Liu ,  Shaoyi Sun ,  Duanjie Hou ,  Nagasree Chakka

Inventor： Rajender Kamboj ,  Zaihui Zhang ,  Jianmin Fu ,  Vishnumurthy Kodumuru ,  Serguei Sviridov ,  Kashinath Sadalapure ,  Shifeng Liu ,  Shaoyi Sun ,  Duanjie Hou ,  Nagasree Chakka

IPC: C07F405/14 ,  A61K31/496 ,  A61K31/501 ,  C07F401/14 ,  A61P9/00 ,  A61P3/10

CPC classification number: A61K31/496 ,  A61K31/501

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，G，J，K ，L，M，V R2，R3，R4，R5，R5a，R6，R6a，R7，R7a，R8和R8a在本文中定义。 还公开了包含式（I）化合物的药物组合物。

公开(公告)号：US20100029722A1

公开(公告)日：2010-02-04

申请号：US12520332

申请日：2007-12-19

Applicant: Natalie Dales ,  Zaihui Zhang ,  Julia Fonarev ,  Jianmin Fu ,  Rajender Kamboj ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia ,  Shaoyi Sun

Inventor： Natalie Dales ,  Zaihui Zhang ,  Julia Fonarev ,  Jianmin Fu ,  Rajender Kamboj ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia ,  Shaoyi Sun

IPC: A61K31/427 ,  C07D417/12 ,  C07D417/14 ,  A61K31/4436 ,  A61P3/00 ,  A61P9/00 ,  A61P17/00

CPC classification number: C07D409/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

公开(公告)号：US20090291957A1

公开(公告)日：2009-11-26

申请号：US12436665

申请日：2009-05-06

Applicant: Rajender Kamboj ,  Jian-min Fu ,  Vishnumurthy Kodumuru ,  Shifeng Liu ,  Kashinath Sadalapure ,  Nagasree Chakka ,  Duanjie Hou ,  Shaoyi Sun

Inventor： Rajender Kamboj ,  Jian-min Fu ,  Vishnumurthy Kodumuru ,  Shifeng Liu ,  Kashinath Sadalapure ,  Nagasree Chakka ,  Duanjie Hou ,  Shaoyi Sun

IPC: A61K31/5025 ,  C07D487/02 ,  C12N9/99 ,  C07D403/02 ,  A61K31/496 ,  A61P9/00 ,  A61P3/00

CPC classification number: A61K31/497 ,  A61K31/50 ,  C07D235/08 ,  C07D487/04

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (II): where x, y, A, D, E, T, Q, G, Z, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (II) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括例如向有需要的哺乳动物施用式（II）化合物：其中x，y，A ，D，E，T，Q，G，Z，J，K，L，M，W，V，R2，R3，R5，R5a，R6，R6a，R7，R7a，R8和R8a。 还公开了包含式（II）化合物的药物组合物。

公开(公告)号：US20090264444A1

公开(公告)日：2009-10-22

申请号：US12378997

申请日：2009-02-20

Applicant: Sultan Chowdhury ,  Natalie Dales ,  Julia Fonarev ,  Jianmin Fu ,  Duanjie Hou ,  Qi Jia ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia ,  Shaoyi Sun ,  Zaihui Zhang

Inventor： Sultan Chowdhury ,  Natalie Dales ,  Julia Fonarev ,  Jianmin Fu ,  Duanjie Hou ,  Qi Jia ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia ,  Shaoyi Sun ,  Zaihui Zhang

IPC: A61K31/497 ,  C07D401/14 ,  A61P3/10

CPC classification number: C07D417/04 ,  C07D417/14

Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract translation: 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。

公开(公告)号：US20080188488A1

公开(公告)日：2008-08-07

申请号：US11575646

申请日：2005-09-20

Applicant: Rajender Kamboj ,  Zaihui Zhang ,  Serguei Sviridov ,  Vandna Raina ,  Duanjie Hou ,  Vishnumurthy Kodumuru ,  Mehran Seid Bagherzadeh

Inventor： Rajender Kamboj ,  Zaihui Zhang ,  Serguei Sviridov ,  Vandna Raina ,  Duanjie Hou ,  Vishnumurthy Kodumuru ,  Mehran Seid Bagherzadeh

IPC: A61K31/495 ,  C12N9/99 ,  A61P3/04 ,  A61P3/10 ,  C07D241/04

CPC classification number: C07D295/192

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, J, K, W, V, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物，其中x，y，J，K，W， V，R 3，R 4，R 5，R 5a，R 6， >，R 6a，R 7，R 7a，R 8和R 8 S 8 >在本文中定义。 还公开了包含式（I）化合物的药物组合物。

公开(公告)号：US20080167321A1

公开(公告)日：2008-07-10

申请号：US11575645

申请日：2005-09-20

Applicant: Rajender Kamboj ,  Vishnumurthy Kodumuru

Inventor： Rajender Kamboj ,  Vishnumurthy Kodumuru

IPC: A61K31/496 ,  C12N9/99 ,  C07D401/04 ,  A61P3/04 ,  A61P3/00 ,  A61P3/10

CPC classification number: C07D213/81 ,  A61K31/496 ,  C07D295/192

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, W, V, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物，其中x，y，G，J，K， L，M，W，V，R2，R3，R4，R5，R5a，R6，R6a，R7，R7a，R8和R8a在本文中定义。 还公开了包含式（I）化合物的药物组合物。

公开(公告)号：US20060205713A1

公开(公告)日：2006-09-14

申请号：US10566856

申请日：2004-07-29

Applicant: Heinz Gschwend ,  Vishnumurthy Kodumuru ,  Shifeng Liu ,  Rajender Kamboj

Inventor： Heinz Gschwend ,  Vishnumurthy Kodumuru ,  Shifeng Liu ,  Rajender Kamboj

IPC: A61K31/551 ,  A61K31/501

CPC classification number: C07D213/75 ,  A61K31/00 ,  A61K31/501 ,  A61K31/551 ,  C07D213/76 ,  C07D213/81 ,  C07D237/20 ,  C07D237/22

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R R 2，R 3，R 4，R 5，R 6，R 6，R 4， R 6a，R 7，R 7a，R 8，R 8a，R 8，R 7， 本文定义了9和9和9 9。 还公开了包含式（I）化合物的药物组合物。

公开(公告)号：US20060199802A1

公开(公告)日：2006-09-07

申请号：US10566193

申请日：2004-07-29

Applicant: Melwyn Abreo ,  Daniel Harvey ,  Heins Gschwend ,  Wenbao Li ,  Chi Tu ,  Rajender Kamboj ,  Michael Winther ,  Vishnumurthy Kodumuru ,  Cindy Hudson ,  Mikhail Kondratenko ,  Shifeng Liu ,  Vandna Raina ,  Serguei Sviridov ,  Zaihui Zhang ,  Mehran Seid Bagherzadeh ,  Shaoyi Sun

Inventor： Melwyn Abreo ,  Daniel Harvey ,  Heins Gschwend ,  Wenbao Li ,  Chi Tu ,  Rajender Kamboj ,  Michael Winther ,  Vishnumurthy Kodumuru ,  Cindy Hudson ,  Mikhail Kondratenko ,  Shifeng Liu ,  Vandna Raina ,  Serguei Sviridov ,  Zaihui Zhang ,  Mehran Seid Bagherzadeh ,  Shaoyi Sun

IPC: A61K31/551 ,  A61K31/496

CPC classification number: C07D213/71 ,  A61K31/00 ,  A61K31/501 ,  C07D213/75 ,  C07D213/76

Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (1): wherein: W is —O—, —N(R1)—, C(O), S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R1)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Abstract translation: 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（1）化合物：其中：W是-O - ， - N （R 1） - ，C（O），S（O）t; （其中t为0,1或2），N（R1）S（O）2，S（O）2N（R1），C（O）N（R1）或N（R1）C（O） ）; 并且V是C（O），C（S），C（O）N（R 1） - ，C（O）O-，S（O）2 - ，S（O）2 N（R 1） - 或C ）H; 并且x，y，R1，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。