公开(公告)号：US4443143A

公开(公告)日：1984-04-17

申请号：US355341

申请日：1982-03-08

申请人： Akira Asari ,  Tatsuhiko Noyori ,  Hidehiro Tsuzuki ,  Takahisa Tabuchi ,  Tsuneharu Masuda ,  Tetsuro Takehata, deceased

发明人： Akira Asari ,  Tatsuhiko Noyori ,  Hidehiro Tsuzuki ,  Takahisa Tabuchi ,  Tsuneharu Masuda ,  Tetsuro Takehata, deceased

IPC分类号： B21C35/06 ,  B21C43/00 ,  B21C43/02 ,  B23D79/12 ,  B23P25/00

CPC分类号： B21C35/06 ,  B21C43/00 ,  Y10S83/914 ,  Y10T29/4561 ,  Y10T409/501148 ,  Y10T409/50164 ,  Y10T409/50328 ,  Y10T409/503608

摘要： A billet scalper including a die assembly with a scalping die, a pressing mechanism with a stem member in axial alignment with the scalping die for pressing a billet thereinto, and a chip ejector located around the circumference of the scalping die and movable axially back and forth beyond a free end face of the scalping die to remove chips therefrom. The die assembly including the scalping die is movable between a position at the center of the scalper and an outer receded position to permit easy maintenance and service of the die assembly including replacements and cleaning of scalping dies. In a preferred form, the scalper is constructed integrally with an extrusion press to perform the billet scalping operation in timed relation with the extruding operation to shorten the time of press cycle.

摘要翻译： 一种包括具有剥皮模具的模具组件的冲压机，具有与用于将坯料挤压的切割模具轴向对准的杆部件的按压机构，以及位于烫金模具的圆周周围并且可轴向运动的芯片喷射器 超过烫金模具的自由端面，以从中除去芯片。 包括烫伤模具的模具组件可在切割器中心的位置和外部退回位置之间移动，以允许容易地维护和维护模具组件，包括替换和清洁烫伤模具。 在优选形式中，定型机与挤压机一体地构造，以与挤压操作定时关系进行坯料切割操作，以缩短压制周期。

公开(公告)号：US4230661A

公开(公告)日：1980-10-28

申请号：US946331

申请日：1978-09-27

申请人： Akira Asari ,  Masakazu Ueda ,  Takeo Nishimoto

发明人： Akira Asari ,  Masakazu Ueda ,  Takeo Nishimoto

IPC分类号： B21C23/20 ,  B21C23/21 ,  B29D23/00

CPC分类号： B21C23/218

摘要： An indirect extrusion process making use of an apparatus having a main ram and a container which are adapted to be driven independently of each other, the container being moved during the extrusion at a speed equal to or higher than that of the main ram, so as to produce the extrusion force, characterized in that the movement of the container relative to the main ram is prevented so that the power for moving the container may be added to the extrusion force, so as to effect extrusion without causing change in the relative position between the container and the billet during extrusion, and that the main ram and the container are connected at a desired position in accordance with the length of the billet, making use of the frictional force exerted between the container and said billet, such that extrusion may be effected with respect to container and the billet in connected state of operation.

摘要翻译： 使用具有主冲头和容器的装置的间接挤压方法，其适于彼此独立地驱动，容器在挤出期间以等于或高于主冲压件的速度移动，以便 以产生挤出力，其特征在于，防止容器相对于主压头的移动，使得用于移动容器的动力可以被添加到挤出力中，以便实现挤出而不引起相对位置之间的变化 在挤出期间的容器和坯料，并且主冲头和容器根据坯料的长度在期望的位置处连接，利用在容器和所述坯料之间施加的摩擦力，使得挤出可以是 对于集装箱和连接运行状态的钢坯而言。

公开(公告)号：US08314079B2

公开(公告)日：2012-11-20

申请号：US13115435

申请日：2011-05-25

申请人： Akira Asari ,  Hitoshi Kurihara ,  Tomomi Shibata ,  Yuka Miyazaki ,  Hiroko Yamanokuchi ,  Akira Tawada ,  Takahiro Masa ,  Yuji Matsuzaki

发明人： Akira Asari ,  Hitoshi Kurihara ,  Tomomi Shibata ,  Yuka Miyazaki ,  Hiroko Yamanokuchi ,  Akira Tawada ,  Takahiro Masa ,  Yuji Matsuzaki

IPC分类号： A61K31/702

CPC分类号： C08B37/0072 ,  A61K31/702 ,  A61K31/728 ,  C07H7/033

摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.

摘要翻译： 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。 保存器官的方法

公开(公告)号：US08153614B2

公开(公告)日：2012-04-10

申请号：US12162415

申请日：2006-12-05

申请人： Akira Asari

发明人： Akira Asari

IPC分类号： A61K31/702

CPC分类号： A61K31/702 ,  A61K31/728 ,  C08L5/08

摘要： There is provided a therapeutic agent for treating osteoarthritis, which is a drug comprising hyaluronan as an active ingredient. The hyaluronan is preferably a tetrasaccharide including two units, with a single unit being -D-glucuronic acid-β-1,3-D-N-acetylglucosamine-β-1,4- (HA4).

摘要翻译： 提供了治疗骨关节炎的治疗剂，其为包含透明质酸作为活性成分的药物。 透明质酸优选为包含两个单元的四糖，单个单元为D-葡萄糖醛酸 - 1,3-葡萄糖醛酸-1,3-D-N-乙酰葡糖胺-1b（-1,4-（HA4））。

公开(公告)号：US20110224169A1

公开(公告)日：2011-09-15

申请号：US13115435

申请日：2011-05-25

申请人： Akira Asari ,  Hitoshi Kurihara ,  Tomomi Shibata ,  Yuka Miyazaki ,  Hiroko Yamanokuchi ,  Akira Tawada ,  Takahiro Masa ,  Yuji Matsuzaki

发明人： Akira Asari ,  Hitoshi Kurihara ,  Tomomi Shibata ,  Yuka Miyazaki ,  Hiroko Yamanokuchi ,  Akira Tawada ,  Takahiro Masa ,  Yuji Matsuzaki

IPC分类号： A61K31/702 ,  A61P1/16 ,  A61P1/04

CPC分类号： C08B37/0072 ,  A61K31/702 ,  A61K31/728 ,  C07H7/033

摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.

摘要翻译： 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。 保存器官的方法

公开(公告)号：US20100234322A1

公开(公告)日：2010-09-16

申请号：US12162415

申请日：2006-12-05

申请人： Akira Asari

发明人： Akira Asari

IPC分类号： A61K31/726 ,  A61K31/715 ,  A61P19/02 ,  C07H3/00

CPC分类号： A61K31/702 ,  A61K31/728 ,  C08L5/08

摘要： There is provided a therapeutic agent for treating osteoarthritis, which is a drug comprising hyaluronan as an active ingredient. The hyaluronan is preferably a tetrasaccharide including two units, with a single unit being -D-glucuronic acid-β-1,3-D-N-acetylglucosamine-β-1,4- (HA4).

摘要翻译： 提供了治疗骨关节炎的治疗剂，其为包含透明质酸作为活性成分的药物。 透明质酸优选为包含两个单元的四糖，单个单元为D-葡萄糖醛酸 - 1,3-葡萄糖醛酸-1,3-D-N-乙酰葡糖胺-1b（-1,4-（HA4））。

公开(公告)号：US07511026B2

公开(公告)日：2009-03-31

申请号：US10550998

申请日：2003-03-25

申请人： Tadahiko Kato ,  Akira Asari

发明人： Tadahiko Kato ,  Akira Asari

IPC分类号： A61K31/728 ,  A61K31/715

CPC分类号： A61K31/70 ,  A61K31/726 ,  A61K31/728 ,  C07H5/06 ,  C07H7/033 ,  C08B37/0072

摘要： The present invention provides a therapeutic agent for nerve damages such as those caused by spinal cord injury or nerve trauma, which includes, as an active ingredient, a low-molecular-weight saccharide composed of at least glucuronic acid and/or N-acetylglucosamine or a pharmaceutically acceptable salt thereof. The present invention also provides a therapeutic agent for nerve damages which includes, as an active ingredient, preferably a low-molecular-weight hyaluronic acid, more preferably hyaluronic acid disaccharide to hyaluronic acid 2,500-saccharide, further more preferably hyaluronic acid disaccharide to hyaluronic acid 50-saccharide, much more preferably hyaluronic acid tetrasaccharide, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供神经损伤治疗剂，例如由脊髓损伤或神经创伤引起的神经损伤，其包括由至少由葡糖醛酸和/或N-乙酰葡糖胺组成的低分子量糖类作为活性成分，或 其药学上可接受的盐。 本发明还提供了一种神经损伤治疗剂，其包括作为活性成分优选为低分子量透明质酸，更优选为透明质酸2,500-糖的透明质酸二糖，进一步优选为透明质酸的透明质酸二糖 50糖，更优选透明质酸四糖，或其药学上可接受的盐。

公开(公告)号：US6159954A

公开(公告)日：2000-12-12

申请号：US317380

申请日：1999-05-24

申请人： Hiroshi Maruyama ,  Kiyoshi Morikawa ,  Akira Tawada ,  Satoshi Miyauchi ,  Keiichi Yoshida ,  Akira Asari

发明人： Hiroshi Maruyama ,  Kiyoshi Morikawa ,  Akira Tawada ,  Satoshi Miyauchi ,  Keiichi Yoshida ,  Akira Asari

IPC分类号： A61K31/737 ,  C07H11/00 ,  C07H13/04 ,  C08B37/00 ,  C12P19/26 ,  A61K31/70

CPC分类号： A61K31/7024 ,  A61K31/702 ,  A61K31/737 ,  C07H11/00 ,  C07H13/04 ,  C08B37/0063 ,  C12P19/26 ,  Y10S514/885

摘要： A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.

摘要翻译： 硫酸角质素寡糖，其包含2至5个糖单元，并且在还原端具有硫酸化的N-乙酰葡糖胺，并且其至少两个羟基被硫酸化的分子中，优选至少含有由式Gal（6S）表示的至少二糖 ）-GlcNAc（6S）（在式中，Gal，GlcN，Ac和6S分别代表半乳糖，葡糖胺，乙酰基和6-O-硫酸酯）作为构成成分，和/或药学上 其可接受的盐用作抗炎剂，抗过敏剂，免疫调节剂，细胞分化诱导剂和凋亡诱导剂的活性成分。

公开(公告)号：US4977774A

公开(公告)日：1990-12-18

申请号：US443493

申请日：1989-11-30

申请人： Akira Asari ,  Kuniaki Kanda ,  Hiroshi Okamoto ,  Masakazu Ueda

发明人： Akira Asari ,  Kuniaki Kanda ,  Hiroshi Okamoto ,  Masakazu Ueda

IPC分类号： B21D22/06

CPC分类号： B21D22/06

摘要： A press device which is reduced in overall height thereof and in deformation of a press frame and can sufficiently support an eccentric load thereto. The press device comprises a press force generating unit disposed in a press frame and including a lid member secured to the press frame, a cross head having a cylinder chamber in which the lid member is fitted for axial sliding movement and having a blank holder at an end face thereof remote from the lid member, and a pressurizing member fitted for axial sliding movement in a portion of the cylinder chamber remote from the lid member. A shaping element is disposed in the press frame in an opposing relationship to the press force generating unit and has a shaping portion in which the pressurizing member is fitted. A guide element is connected to the cross head for guiding the cross head for axial sliding movement, and a cross head actuating device is connected to the cross head for axially moving the cross head under the guidance of the guide element independently of the pressurizing member.

公开(公告)号：US4708627A

公开(公告)日：1987-11-24

申请号：US946643

申请日：1986-12-29

申请人： Akira Asari ,  Youichi Inoue

发明人： Akira Asari ,  Youichi Inoue

IPC分类号： B22F3/14 ,  B22F3/15 ,  B30B11/00 ,  C04B35/64 ,  F27B17/00

CPC分类号： B30B11/002 ,  B22F2003/153

摘要： A high pressure apparatus in which a support frame which undergoes axial tension includes a divided body composed of first and second support frames, the first and second support frames being brought into engagement with each other at an outward area in a diametrical direction of upper and lower covers and being freely changed in position between the engaging position and a position separated from each other. Either one or both of the upper and lower covers are provided with a member which extends outwardly in an axial direction so that products may be removed from a cylindrical high pressure container.

摘要翻译： 其中承受轴向张力的支撑框架的高压装置包括由第一和第二支撑框架构成的分隔体，第一和第二支撑框架在上下方向上的外部区域彼此接合 覆盖并且在接合位置和彼此分离的位置之间的位置自由地改变。 上盖和下盖中的一个或两个设置有沿轴向方向向外延伸的构件，使得产品可以从圆柱形高压容器移除。