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53 条记录 (耗时 0.036 秒)

    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
    45.
    发明授权
    Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效
    用于将流体敏感生长激素递送至牛类动物的渗透系统

    公开(公告)号：US5980509A

    公开(公告)日：1999-11-09

    申请号：US976513

    申请日：1997-11-24

    申请人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    发明人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery ,  James B. Pike ,  Urano A. Robinson ,  Jonathan P. Smith ,  Lyle E. Ziemann

    IPC分类号： A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M31/00

    CPC分类号： A61K9/0004 ,  A61D7/00 ,  A61M31/002

    摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may be adapted for ultrasonic welding to the first wall section and may maintain the beneficial agent in contact with an exit. The compartment comprises a beneficial agent and an expandable driving member. The delivery system comprises an exit for delivering the beneficial agent to the animal. The exit may compensate for slight variations in the efflux rate of the beneficial agent and maintain a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.

    摘要翻译： 公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。 输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。 壁可以进一步包括可适于超声波焊接到第一壁部分的端盖，并且可以使有益剂保持与出口接触。 隔室包括有益剂和可膨胀的驱动构件。 递送系统包括用于将有益药物递送给动物的出口。 出口可以补偿有益剂的流出速率的轻微变化，并将有益药剂从装置向外保持足够的速度或流出速率，同时使流体从外部环境扩散回到装置中。

    Delivery device with a protective sleeve
    47.
    发明授权
    Delivery device with a protective sleeve 失效
    输送装置带有保护套

    公开(公告)号：US5234693A

    公开(公告)日：1993-08-10

    申请号：US939247

    申请日：1992-09-02

    申请人： Judy A. Magruder ,  John R. Peery ,  James B. Eckenhoff

    发明人： Judy A. Magruder ,  John R. Peery ,  James B. Eckenhoff

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluidimpermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections. The protective sleeve is preferably configured to provide substantially no resistance to flow of fluid vapor through the fluid-permeable second wall section.

    摘要翻译： 本发明涉及活性剂递送装置。 更具体地，本发明涉及一种输送装置，其包括用于保护输送装置免受瞬时机械力的套筒。 本发明的输送装置是坚固的并且耐瞬态机械力。 本发明提供一种流体吸收递送装置，其包括封闭内部隔室的壳体，所述壳体具有基本上限制流体进入输送装置的第一壁部分，即基本上不透液体，并且含有有益剂; 允许流体进入输送装置的第二壁部分，即流体可渗透的，并且其包含至少一个可膨胀的驱动构件; 出口手段; 具有从壳体的第一壁部分延伸以覆盖并保护壳体的第二壁部分和第一和第二部分的连接处的保护套筒装置。 保护套管优选地构造成基本上不提供通过流体可渗透的第二壁部分的流体蒸汽的流动阻力。

    Delivery device with a protective sleeve
    48.
    发明授权
    Delivery device with a protective sleeve 失效
    具有保护套的交付装置

    公开(公告)号：US5180591A

    公开(公告)日：1993-01-19

    申请号：US551720

    申请日：1990-07-11

    申请人： Judy A. Magruder ,  John R. Peery ,  James B. Eckenhoff

    发明人： Judy A. Magruder ,  John R. Peery ,  James B. Eckenhoff

    IPC分类号： A61M5/148 ,  A61K20060101 ,  A61K9/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61K9/0004

    摘要： This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections. The protective sleeve is preferably configured to provide substantially no resistance to flow of fluid or fluid vapors through the fluid-permeable second wall section.

    摘要翻译： 本发明涉及活性剂递送装置。 更具体地，本发明涉及一种输送装置，其包括用于保护输送装置免受瞬时机械力的套筒。 本发明的输送装置是坚固的并且耐瞬态机械力。 本发明提供了一种流体吸收递送装置，其包括封闭内部隔室的壳体，所述壳体具有基本上限制流体进入输送装置的第一壁部分，即基本上不流体渗透，并且包含有益剂; 允许流体进入输送装置的第二壁部分，即流体可渗透的，并且其包含至少一个可膨胀的驱动构件; 出口手段; 具有从壳体的第一壁部分延伸以覆盖并保护壳体的第二壁部分和第一和第二部分的连接处的保护套筒装置。 保护套管优选地构造成基本上不提供通过流体可渗透的第二壁部分的流体或流体蒸气的流动阻力。