公开(公告)号：US20090131410A1

公开(公告)日：2009-05-21

申请号：US12089150

申请日：2006-10-05

Applicant: Naresh Kumar ,  Kirandeep Kaur ,  Suman Gupta ,  Anita Chugh ,  Mohammad Salman ,  Raj Kumar Shirumalla ,  Shivani Malhotra

Inventor： Naresh Kumar ,  Kirandeep Kaur ,  Suman Gupta ,  Anita Chugh ,  Mohammad Salman ,  Raj Kumar Shirumalla ,  Shivani Malhotra

IPC: A61K31/55 ,  C07D223/14 ,  A61P3/10

CPC classification number: C07D221/24 ,  C07D405/12 ,  C07D409/12

Abstract: Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 提供毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 还提供了用于制备本文所述的化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090105221A1

公开(公告)日：2009-04-23

申请号：US11576096

申请日：2005-09-28

Applicant: Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Arani Pal ,  Anita Chugh ,  Suman Gupta ,  Venkata P. Palle ,  Naresh Kumar ,  Kirandeep Kaur

Inventor： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Arani Pal ,  Anita Chugh ,  Suman Gupta ,  Venkata P. Palle ,  Naresh Kumar ,  Kirandeep Kaur

IPC: A61K31/55 ,  C07D223/14 ,  C07D405/12 ,  A61P11/00 ,  A61P1/00

CPC classification number: C07D401/12 ,  C07D221/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12

Abstract: This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the prepration of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及所述化合物的制备方法，包含所公开的化合物的药物组合物，以及通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US07378535B2

公开(公告)日：2008-05-27

申请号：US11414552

申请日：2006-05-01

Applicant: Roger Read ,  Naresh Kumar

Inventor： Roger Read ,  Naresh Kumar

IPC: C07D307/58

CPC classification number: C08F20/00 ,  A01N43/08 ,  C07D307/58 ,  C08F24/00

Abstract: The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl chain, especially fimbrolide alcohols, carboxylate and sulfinate and sulfonate esters, ethers, aldehydes, ketones, acids, amides, nitro derivatives, hydrophobic, hydrophilic and fluorophilic alkyl derivatives and polymers.

Abstract translation: 本发明涉及福滨洛尔（卤代3-烷基-5-亚甲基-2（5H） - 呋喃酮）及其合成类似物的侧链官能化，其产生在烷基中被卤素，氧或氮官能团取代的菲莫拉林 链，特别是福美罗瑞醇，羧酸盐和亚磺酸盐和磺酸酯，醚，醛，酮，酸，酰胺，硝基衍生物，疏水性，亲水和氟化烷基衍生物和聚合物。

公开(公告)号：US20070261107A1

公开(公告)日：2007-11-08

申请号：US11418051

申请日：2006-05-03

Applicant: Raymond Ng ,  Ganesh Kirti ,  Thomas Keefe ,  Naresh Kumar

Inventor： Raymond Ng ,  Ganesh Kirti ,  Thomas Keefe ,  Naresh Kumar

IPC: H04L9/32

CPC classification number: H04L63/062

Abstract: One embodiment of the present invention provides a system that facilitates accessing a credential. During operation, the system receives a request at a credentials-storage framework (CSF) to retrieve the credential. If a target credential store containing the credential is not already connected to the CSF, the system looks up a bootstrap credential for the target credential store in a bootstrap credential store, which contains bootstrap credentials for other credential stores. Next, the system uses this bootstrap credential to connect the CSF to the target credential store. Finally, the system retrieves the credential from the target credential store, and returns the credential to the requestor.

Abstract translation: 本发明的一个实施例提供一种便于访问证书的系统。 在操作期间，系统在凭证存储框架（CSF）处接收请求以检索凭证。 如果包含凭据的目标凭据存储库尚未连接到CSF，则系统将在引导凭证存储中查找目标凭据存储的引导凭据，其中包含其他凭据存储的引导凭据。 接下来，系统使用此引导凭据将CSF连接到目标凭据存储。 最后，系统从目标凭证存储中检索凭证，并将凭证返回给请求者。

公开(公告)号：US20070136819A1

公开(公告)日：2007-06-14

申请号：US11296086

申请日：2005-12-06

Applicant: Raymond Ng ,  Ganesh Kirti ,  Thomas Keefe ,  Naresh Kumar

Inventor： Raymond Ng ,  Ganesh Kirti ,  Thomas Keefe ,  Naresh Kumar

IPC: H04L9/32

CPC classification number: H04L63/08

Abstract: Systems, methods, and machine-readable media are disclosed for providing conditional grants of permission in an externally configured security policy. In one embodiment, a method is provided which comprises reading a condition clause from a grant statement defined in the security policy. The grant statement can cause the granting of permission for a user to access a requested resource. One or more constraints on the grant statement can be determined based on the condition clause. Permission can be granted to access the requested resource based on the one or more constraints.

Abstract translation: 公开了用于在外部配置的安全策略中提供有限许可的系统，方法和机器可读介质。 在一个实施例中，提供了一种方法，其包括从安全策略中定义的授权语句读取条件子句。 授权语句可能导致授予用户访问所请求资源的权限。 授权语句的一个或多个约束可以基于条件子句来确定。 可以授予权限以基于一个或多个约束来访问所请求的资源。

公开(公告)号：US07148355B2

公开(公告)日：2006-12-12

申请号：US10490275

申请日：2002-09-24

Applicant: Purna Chandra Ray ,  Jayachandra Suresh Babu ,  Mohammad Salman ,  Naresh Kumar

Inventor： Purna Chandra Ray ,  Jayachandra Suresh Babu ,  Mohammad Salman ,  Naresh Kumar

IPC: C07D211/32

CPC classification number: C07D295/135

Abstract: The present invention relates to a cost effective and industrially advantageous process for the preparation of repaglinide.

Abstract translation: 本发明涉及用于制备瑞格列奈的成本效益和工业上有利的方法。

公开(公告)号：US07064220B1

公开(公告)日：2006-06-20

申请号：US09673305

申请日：1999-04-16

Applicant: Roger Read ,  Naresh Kumar

Inventor： Roger Read ,  Naresh Kumar

IPC: C07D307/58 ,  A01N43/08

CPC classification number: C08F20/00 ,  A01N43/08 ,  C07D307/58 ,  C08F24/00

Abstract: The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl chain, especially fimbrolide alcohols, carboxylate and sulfinate and sulfonate esters, ethers, aldehydes, ketones, acids, amides, nitro derivatives, hydrophobic, hydrophilic and fluorophilic alkyl derivatives and a polymers.

Abstract translation: 本发明涉及福滨洛尔（卤代3-烷基-5-亚甲基-2（5H） - 呋喃酮）及其合成类似物的侧链官能化，其产生在烷基中被卤素，氧或氮官能团取代的菲莫拉林 链，特别是福美罗瑞醇，羧酸酯和亚磺酸盐和磺酸酯，醚，醛，酮，酸，酰胺，硝基衍生物，疏水性，亲水和氟化烷基衍生物和聚合物。

公开(公告)号：US07052910B2

公开(公告)日：2006-05-30

申请号：US09984018

申请日：2001-10-26

Applicant: Naresh Kumar ,  Chinmoy Sankar Dey

Inventor： Naresh Kumar ,  Chinmoy Sankar Dey

IPC: C12N5/06 ,  C12N5/00 ,  C12N5/02

CPC classification number: C07K16/18 ,  C07K16/26 ,  C07K16/2869 ,  G01N33/5061 ,  G01N2800/042

Abstract: The present invention relates to the development of insulin resistant skeletal muscle cell culture model useful for the screening of compounds that enhance insulin receptor (IR) and insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation required against type II diabetes.

公开(公告)号：US06677485B2

公开(公告)日：2004-01-13

申请号：US10149624

申请日：2002-08-09

Applicant: Naresh Kumar ,  Bakthavathsalan Vijayaraghavan ,  Kinali Venkata Ramana ,  Swargam Sathyanarayana

Inventor： Naresh Kumar ,  Bakthavathsalan Vijayaraghavan ,  Kinali Venkata Ramana ,  Swargam Sathyanarayana

IPC: C07C21702

CPC classification number: C07C213/06 ,  C07C217/48

Abstract: An improved and industrially advantageous process for the preparation of the antidepressant fluoxetine and its pharmaceutically acceptable salts, preferably hydrochloride.

Abstract translation: 一种用于制备抗抑郁药氟西汀及其药学上可接受的盐，优选盐酸盐的改进和工业上有利的方法。

公开(公告)号：US5070195A

公开(公告)日：1991-12-03

申请号：US490151

申请日：1990-03-07

Applicant: Jag M. Khanna ,  Naresh Kumar ,  Kiran Bala ,  Yatendra Kumar

Inventor： Jag M. Khanna ,  Naresh Kumar ,  Kiran Bala ,  Yatendra Kumar

IPC: C07D205/095 ,  C07D501/00

CPC classification number: C07D501/00 ,  C07D205/095

Abstract: An improved method for preparing 2-chlorosulfinyl azetidine-4-one comprises heating a penicillin sulfoxide ester with an N-chlorohalogenating agent at a temperature of about 75.degree. C. to about 140.degree. in an inert organic solvent, and in the presence of an organic solvent insoluble, strongly basic ion exchange resin. Desirably, the ion exchange resin comprises a styrene-divinyl benzane copolymer which is about 2 to 16% cross-linked and incorporates a quaternary ammonium functionality. Such ion exchange resins are commercially available. The 2-chlorosulfinyl azetidine-4-one which is produced by this method can be cyclized in the presence of a Friedel-Crafts catalysts to afford the 3-exomethylene cepham sulfoxide ester in yields of 80-90%.

Abstract translation: 制备2-氯亚磺酰基氮杂环丁烷-4-酮的改进方法包括在惰性有机溶剂中，在约75℃至约140℃的温度下，用N-氯代卤化剂加热青霉素亚砜酯，并在 有机溶剂不溶，强碱性离子交换树脂。 期望地，离子交换树脂包含交联的约2至16％的苯乙烯 - 二乙烯基苯基共聚物并结合季铵官能团。 这样的离子交换树脂是可商购的。 通过该方法制备的2-氯亚磺酰基氮杂环丁烷-4-酮可以在Friedel-Crafts催化剂存在下环化，得到3-异亚甲基头孢烯亚砜酯，产率为80-90％。