公开(公告)号：US20200376173A1

公开(公告)日：2020-12-03

申请号：US16996229

申请日：2020-08-18

Applicant: Battelle Memorial Institute

Inventor： Gaurav Sharma ,  Ramanathan S. Lalgudi ,  Chad E. Bouton

IPC: A61L31/10 ,  A61N1/05

Abstract: A chronically implanted medical device is disclosed that has an outermost layer formed from a conjugate of a polymer with lipoic acid, the conjugate having free 1,2-dithiolane groups. It is contemplated that this layer scavenges reactive oxygen species, i.e. acts as an antioxidant, and thus reduces inflammation and other adverse effects around the implant itself.

公开(公告)号：US10285934B1

公开(公告)日：2019-05-14

申请号：US15340923

申请日：2016-11-01

Applicant: Battelle Memorial Institute

Inventor： Gaurav Sharma ,  Chad Bouton

IPC: A61K9/00 ,  A61K47/02 ,  A61N1/32 ,  A61N2/00 ,  A61N2/02

Abstract: A method of administering a drug into the brain of a mammal (human or nonhuman) is described. In this method, a magneto-electric nanoparticle (MENP) and a drug are injected into the blood stream of a mammal. The MENP attaches to the blood-brain barrier (BBB) and a non-alternating electric or magnetic field is applied. In an alternative, the non-alternating field could be replaced by a slowly alternating field so as to avoid localized heating. The step of applying an electric or magnetic field causes an increase in the permeability of the BBB to the drug so that the drug passes into the brain while the MENP remains attached to the BBB.

公开(公告)号：US20180078681A1

公开(公告)日：2018-03-22

申请号：US15807979

申请日：2017-11-09

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Gaurav Sharma ,  Ramanathan S. Lalgudi ,  Chad E. Bouton

IPC: A61L31/10 ,  A61N1/05 ,  C08L33/08

CPC classification number: A61L31/10 ,  A61L2400/18 ,  A61N1/0536 ,  C08L33/08

Abstract: A chronically implanted medical device is disclosed that has an outermost layer formed from a conjugate of a polymer with lipoic acid, the conjugate having free 1,2-dithiolane groups. It is contemplated that this layer scavenges reactive oxygen species, i.e. acts as an antioxidant, and thus reduces inflammation and other adverse effects around the implant itself.

公开(公告)号：US20150306373A1

公开(公告)日：2015-10-29

申请号：US14728512

申请日：2015-06-02

Applicant: Battelle Memorial Institute

Inventor： Chad E. Bouton ,  Jeffrey Friend ,  Gaurav Sharma ,  Andrew Sweeney ,  Amy M. Heintz ,  Stephanie Kute ,  Nicholas Annetta ,  Thomas D. Haubert ,  Steven M. Risser

IPC: A61N1/04 ,  G06F3/01 ,  A61N1/36

CPC classification number: A61N1/0484 ,  A61N1/0456 ,  A61N1/36003 ,  G06F3/015 ,  G06F3/017

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Abstract translation: 本公开涉及神经肌肉刺激和感测袖口。 神经肌肉刺激袖口具有至少两个手指和设置在每个手指上的多个电极。 更一般地，神经肌肉刺激套囊包括外部可重复使用的部件和内部的一次性部件。 一个或多个电极容纳在可重复使用的部件内。 神经肌肉刺激袖带可以通过提供绝缘基底层来形成，在基底层上形成导电电路以形成导电电路层，将覆盖层粘附到导电电路层上以形成柔性电路，并且切割至少一个柔性电缆 手指从柔性电路。 神经肌肉刺激袖口使用灵活的多电极设计，其允许对患者中的复杂肌肉运动进行再动作，包括单独的手指运动。