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41.TNF-alpha variants proteins for the treatment of TNF-alpha related disorders 有权
标题翻译: TNF-α变体蛋白用于治疗TNF-α相关疾病公开(公告)号:US07244823B2
公开(公告)日:2007-07-17
申请号:US10262630
申请日:2002-09-30
申请人: Bassil I. Dahiyat , John R. Desjarlais , Anton Filikov , Umesh Muchhal , Malu Lourdes G. Tansey , Jonathan Zalevsky
发明人: Bassil I. Dahiyat , John R. Desjarlais , Anton Filikov , Umesh Muchhal , Malu Lourdes G. Tansey , Jonathan Zalevsky
CPC分类号: A61K38/191 , C07K14/525
摘要: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
摘要翻译: 本发明涉及具有TNF-α拮抗剂活性的新型蛋白质和编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗TNF-α相关疾病中的用途。
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42.Nucleic acids and protein variants of hG-CSF with granulopoietic activity 失效
标题翻译: 具有粒细胞生成活性的hG-CSF的核酸和蛋白质变体公开(公告)号:US07208473B2
公开(公告)日:2007-04-24
申请号:US10632695
申请日:2003-08-01
申请人: Bassil I. Dahiyat , Peizhi Luo
发明人: Bassil I. Dahiyat , Peizhi Luo
IPC分类号: A61K38/16 , A61K38/18 , C07K14/00 , C07K14/535 , C12N15/27
CPC分类号: C07K14/535 , A61K38/00
摘要: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
摘要翻译: 本发明涉及新型粒细胞生成活性(GPA)蛋白和核酸。 本发明还涉及GPA蛋白在治疗G-CSF相关疾病中的用途。
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公开(公告)号:US06946265B1
公开(公告)日:2005-09-20
申请号:US09571024
申请日:2000-05-12
申请人: Anton Filikov , Bassil I. Dahiyat
发明人: Anton Filikov , Bassil I. Dahiyat
摘要: The invention relates to novel growth hormone activity (GHA) proteins and nucleic acids. The invention further relates to the use of the GHA proteins in the treatment of growth hormone related disorders.
摘要翻译: 本发明涉及新的生长激素活性(GHA)蛋白和核酸。 本发明还涉及GHA蛋白在治疗生长激素相关病症中的用途。
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公开(公告)号:US06804611B2
公开(公告)日:2004-10-12
申请号:US09837886
申请日:2001-04-18
IPC分类号: G01N3100
CPC分类号: C12N15/1089 , C07K1/00 , C07K1/003 , C07K14/001 , C12N15/1034 , G06F19/16 , G06F19/18 , G06F19/22
摘要: The present invention relates to apparatus and methods for quantitative protein design and optimization.
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公开(公告)号:US06801861B2
公开(公告)日:2004-10-05
申请号:US09827960
申请日:2001-04-04
IPC分类号: G01N3100
CPC分类号: C12N15/1089 , C07K1/00 , C07K1/003 , C07K14/001 , C12N15/1034 , G06F19/16 , G06F19/18 , G06F19/22
摘要: The present invention relates to apparatus and methods for quantitative protein design and optimization.
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46.Nucleic acids and protein variants of hG-CSF with granulopoietic activity 失效
标题翻译: 具有粒细胞生成活性的hG-CSF的核酸和蛋白质变体公开(公告)号:US06627186B1
公开(公告)日:2003-09-30
申请号:US09479313
申请日:2000-01-06
申请人: Bassil I. Dahiyat , Peizhi Luo
发明人: Bassil I. Dahiyat , Peizhi Luo
IPC分类号: A61K3819
CPC分类号: C07K14/535 , A61K38/00
摘要: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
摘要翻译: 本发明涉及新型粒细胞生成活性(GPA)蛋白和核酸。 本发明还涉及GPA蛋白在治疗G-CSF相关疾病中的用途。
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公开(公告)号:US06188965B1
公开(公告)日:2001-02-13
申请号:US09058459
申请日:1998-04-10
IPC分类号: G01N3100
CPC分类号: C12N15/1089 , C07K1/00 , C07K1/003 , C07K14/001 , C12N15/1034 , G06F19/16 , G06F19/18 , G06F19/22
摘要: The present invention relates to apparatus and methods for quantitative protein design and optimization.
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