利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.039 秒)

    Engineered lectin oligomers with antiviral activity
    1.
    发明授权
    Engineered lectin oligomers with antiviral activity 有权
    具有抗病毒活性的工程凝集素寡聚体

    公开(公告)号：US08865876B2

    公开(公告)日：2014-10-21

    申请号：US12476660

    申请日：2009-06-02

    申请人： Stephen L. Mayo ,  Jennifer Keeffe ,  Alex L. Perryman

    发明人： Stephen L. Mayo ,  Jennifer Keeffe ,  Alex L. Perryman

    IPC分类号： C07K1/00 ,  C07K14/47 ,  A61K38/00

    CPC分类号： C07K14/4726 ,  A61K38/00 ,  C07K2319/30

    摘要： Engineered lectins and methods of using such reagents for both preventing and treating a broad array of viral infections are provided. The lectins of the invention are engineered in two ways, first through the enhancement of the natural mode of action of lectins against viruses through linked multimerization, and second through the creation of a new class of reagents, hereinafter referred to as a “lectibody” or “lectibodies”, that engage host immune function in addition to simply binding glycosylated viral proteins via the combination of a lectin and the Fc region of an antibody in order to drive Fc-mediated effector functions including ADCC (antibody-dependent cell-mediated cytotoxicity), increased half-life, complement-dependent cytotoxicity (CDC), and antibody-dependent cell-mediated phagocytosis (ADCP) in response to a lectin-mediated carbohydrate-binding event.

    摘要翻译： 提供了用于预防和治疗广泛病毒感染的这些试剂的工程凝集素和方法。 本发明的凝集素以两种方式设计，首先是通过连接多聚化来增强凝集素对病毒的自然作用模式，其次通过创建新一类试剂（以下称为“介体抗体”）或 除了通过凝集素和抗体的Fc区的组合简单地结合糖基化的病毒蛋白质以驱动Fc介导的效应子功能（包括ADCC（抗体依赖性细胞介导的细胞毒性））之外，它还涉及宿主免疫功能， ，增加的半衰期，补体依赖性细胞毒性（CDC）和抗体依赖性细胞介导的吞噬作用（ADCP）响应凝集素介导的碳水化合物结合事件。

    ENGINEERED LECTINS FOR VIRAL INACTIVATION
    6.
    发明申请
    ENGINEERED LECTINS FOR VIRAL INACTIVATION 有权
    用于病毒灭活的工程师

    公开(公告)号：US20090297516A1

    公开(公告)日：2009-12-03

    申请号：US12476660

    申请日：2009-06-02

    申请人： Stephen L. Mayo ,  Jennifer Keeffe ,  Alex L. Perryman

    发明人： Stephen L. Mayo ,  Jennifer Keeffe ,  Alex L. Perryman

    IPC分类号： A61K38/16 ,  C07K14/42 ,  C07K16/00 ,  A61K39/395 ,  A61P31/12

    CPC分类号： C07K14/4726 ,  A61K38/00 ,  C07K2319/30

    摘要： Engineered lectins and methods of using such reagents for both preventing and treating a broad array of viral infections are provided. The lectins of the invention are engineered in two ways, first through the enhancement of the natural mode of action of lectins against viruses through linked multimerization, and second through the creation of a new class of reagents, hereinafter referred to as a “lectibody” or “lectibodies”, that engage host immune function in addition to simply binding glycosylated viral proteins via the combination of a lectin and the Fc region of an antibody in order to drive Fc-mediated effector functions including ADCC (antibody-dependent cell-mediated cytotoxicity), increased half-life, complement-dependent cytotoxicity (CDC), and antibody-dependent cell-mediated phagocytosis (ADCP) in response to a lectin-mediated carbohydrate-binding event.

    摘要翻译： 提供了用于预防和治疗广泛病毒感染的这些试剂的工程凝集素和方法。 本发明的凝集素以两种方式设计，首先是通过连接多聚化来增强凝集素对病毒的自然作用模式，其次通过创建新一类试剂（以下称为“介体抗体”）或 除了通过凝集素和抗体的Fc区的组合简单地结合糖基化的病毒蛋白质以驱动Fc介导的效应子功能（包括ADCC（抗体依赖性细胞介导的细胞毒性））之外，它还涉及宿主免疫功能， ，增加的半衰期，补体依赖性细胞毒性（CDC）和抗体依赖性细胞介导的吞噬作用（ADCP）响应凝集素介导的碳水化合物结合事件。