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公开(公告)号：US10605813B2
公开(公告)日：2020-03-31
申请号：US16256582
申请日：2019-01-24
摘要： Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.
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公开(公告)号：US20200002540A1
公开(公告)日：2020-01-02
申请号：US16368513
申请日：2019-03-28
发明人： Glenn Bartholomew , Yongchao Liang , Brian Wall , David Moureau
摘要： Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.
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公开(公告)号：US09719998B2
公开(公告)日：2017-08-01
申请号：US15059190
申请日：2016-03-02
CPC分类号： G01N33/582 , C08G61/02 , C08G2261/124 , C08G2261/1424 , C08G2261/148 , C08G2261/1644 , C08G2261/312 , C08G2261/3142
摘要： Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.
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公开(公告)号：US20160266131A1
公开(公告)日：2016-09-15
申请号：US15059190
申请日：2016-03-02
CPC分类号： G01N33/582 , C08G61/02 , C08G2261/124 , C08G2261/1424 , C08G2261/148 , C08G2261/1644 , C08G2261/312 , C08G2261/3142
摘要： Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.
摘要翻译： 提供了具有紫外吸收最大值的水溶性光收获多重色谱。 在一些实施方案中，多色素包括包含稠合的6-5-6三环共聚单体和UV吸光度改性共聚单体的共轭链段。 多重色素可以包括与能量接收邻近的多重色谱共价连接的受体发色团。 在一些实施方案中，特异性结合成员共价连接到多色素。 还提供了评价样品存在目标分析物的方法和使用包含光收集多色谱的组合物标记靶分子的方法。 还提供了用于实践主题方法的套件和系统。
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