Blood pressure measuring device and method of calibrating thereof
    42.
    发明授权
    Blood pressure measuring device and method of calibrating thereof 有权
    血压测量装置及其校准方法

    公开(公告)号:US09204809B2

    公开(公告)日:2015-12-08

    申请号:US13364297

    申请日:2012-02-01

    IPC分类号: A61B5/021 A61B5/026 A61B5/00

    摘要: The present invention is a blood pressure measuring device comprising an optical sensing unit adapted for detecting optical pulses at a plurality of locations on an external surface of a user. The device also comprises a processing unit coupled to the optical sensing unit for determining an optimal location from the plurality of locations based on the detected optical pulses and a pressure sensing unit adapted for detecting a pressure pulse of the user at a location of measurement. The present invention also discloses a method of measuring a blood pressure of a user using a blood pressure measurement device. The advantage of the present invention is that by using an optical sensing unit to locate the artery of the user, or to compensate the misalignment from the artery, the blood pressure is more accurately determined. With the calibration method, the deficient cuff calibration can be waived in certain circumstances.

    摘要翻译: 本发明是一种血压测量装置,其包括适于检测用户外表面上的多个位置处的光脉冲的光学感测单元。 该装置还包括耦合到光学感测单元的处理单元,用于基于检测到的光脉冲确定来自多个位置的最佳位置;以及压力感测单元,适于在测量位置检测用户的压力脉冲。 本发明还公开了一种使用血压测量装置测量使用者的血压的方法。 本发明的优点在于,通过使用光学感测单元来定位用户的动脉,或者补偿与动脉的不对准,可以更精确地确定血压。 使用校准方法,可以在某些情况下放弃缺陷袖带校准。

    Dynamically adjusting active members in multichassis link bundle
    43.
    发明授权
    Dynamically adjusting active members in multichassis link bundle 有权
    动态调整多机箱链路捆绑中的活动成员

    公开(公告)号:US08902738B2

    公开(公告)日:2014-12-02

    申请号:US13343095

    申请日:2012-01-04

    IPC分类号: H04L12/28 H04L12/26

    摘要: In one embodiment, active links are added to, and removed from, a multichassis link bundle with one side of the multichassis link bundle terminated on multiple devices of a multichassis device. In one embodiment, adding active links includes selecting which particular device to which to add an active link to the multichassis link bundle based on a device priority of each of the multiple devices, with a device priority of a given device being based on a current number of active links associated with the given device.

    摘要翻译: 在一个实施例中,活动链路被添加到多架构链路束并从多架架链路束的一侧被移除,多个机箱链路束的一侧终止于多机架设备的多个设备上。 在一个实施例中,添加活动链路包括基于每个多个设备的设备优先级来选择哪个特定设备向多架设链路束添加活动链路,其中给定设备的设备优先级基于当前号码 与给定设备相关联的活动链路。

    PEGYLATED ANALOGUE PROTEIN OR CANINE URATE OXIDASE, PREPARATION METHOD AND USE THEREOF
    44.
    发明申请
    PEGYLATED ANALOGUE PROTEIN OR CANINE URATE OXIDASE, PREPARATION METHOD AND USE THEREOF 有权
    聚乙二醇化的模拟蛋白或犬尿酸氧化酶,制备方法及其用途

    公开(公告)号:US20140065123A1

    公开(公告)日:2014-03-06

    申请号:US13985273

    申请日:2012-02-14

    IPC分类号: C12N9/96

    摘要: Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.

    摘要翻译: 提供犬尿酸氧化酶的聚乙二醇化类似蛋白,其制备方法和用途。 犬尿酸氧化酶的类似蛋白是犬尿酸氧化酶,或包含犬尿酸氧化酶的部分氨基酸序列和人尿酸氧化酶的部分氨基酸序列的嵌合蛋白或其突变蛋白。 犬尿酸氧化酶的聚乙二醇化类似物蛋白及其药物组合物可用于预防和/或治疗高尿酸血症和慢性痛风。

    Carbon nanotube and nanofiber film-based membrane electrode assemblies
    46.
    发明授权
    Carbon nanotube and nanofiber film-based membrane electrode assemblies 有权
    碳纳米管和纳米纤维膜基膜电极组件

    公开(公告)号:US08415012B2

    公开(公告)日:2013-04-09

    申请号:US12505070

    申请日:2009-07-17

    IPC分类号: H01M8/10 H01M4/88

    摘要: A membrane electrode assembly (MEA) for a fuel cell comprising a catalyst layer and a method of making the same. The catalyst layer can include a plurality of catalyst nanoparticles, e.g., platinum, disposed on buckypaper. The catalyst layer can have 1% or less binder prior to attachment to the membrane electrode assembly. The catalyst layer can include (a) single-wall nanotubes, small diameter multi-wall nanotubes, or both, and (b) large diameter multi-wall nanotubes, carbon nanofibers, or both. The ratio of (a) to (b) can range from 1:2 to 1:20. The catalyst layer can produce a surface area utilization efficiency of at least 60% and the platinum utilization efficiency can be 0.50 gPt/kW or less.

    摘要翻译: 一种用于燃料电池的膜电极组件(MEA),其包括催化剂层及其制造方法。 催化剂层可以包括设置在压缩纸上的多个催化剂纳米颗粒,例如铂。 催化剂层可以在连接到膜电极组件之前具有1%以下的粘合剂。 催化剂层可以包括(a)单壁纳米管,小直径多壁纳米管或两者,和(b)大直径多壁纳米管,碳纳米纤维或两者。 (a)至(b)的比例可以为1:2至1:20。 催化剂层可以产生至少60%的表面积利用效率,铂利用效率可以为0.50gPt / kW以下。

    HOMODIMER OF INSULINOTROPIC PEPTIDE ANALOGUES AND METHOD FOR PREPARATION THEREOF AND USE THEREOF
    48.
    发明申请
    HOMODIMER OF INSULINOTROPIC PEPTIDE ANALOGUES AND METHOD FOR PREPARATION THEREOF AND USE THEREOF 有权
    胰岛素类肽类似物的制备方法及其制备方法及其用途

    公开(公告)号:US20120277154A1

    公开(公告)日:2012-11-01

    申请号:US13391097

    申请日:2010-03-15

    IPC分类号: C07K19/00 A61P3/00 A61K38/26

    摘要: Provided is a homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof, wherein the insulinotropic peptide analogue comprises GLP-1 and Exendin-4. The homodimer of insulinotropic peptide analogues of the invention is made by conjugating two identical insulinotropic peptide analogue molecules at the C-terminal Cys residues via disulfide bond or PEG molecule. The homodimer of insulinotropic peptide analogues of the invention has superior stability and biological activity in vivo, and prolonged half-life in the circulation, and can be used for the preparation of hypoglycemic drugs.

    摘要翻译: 提供促胰岛素肽类似物的同型二聚体及其制备方法及其应用,其中促胰岛素肽类似物包含GLP-1和毒蜥外泌肽-4。 本发明的促胰岛素肽类似物的同型二聚体通过在C末端Cys残基上通过二硫键或PEG分子缀合两个相同的促胰岛素肽类似物分子来制备。 本发明的促胰岛素肽类似物的同型二聚体在体内具有优异的稳定性和生物活性,并且循环中的半衰期延长,并且可用于制备降血糖药物。

    CATALYTIC ELECTRODE WITH GRADIENT POROSITY AND CATALYST DENSITY FOR FUEL CELLS
    50.
    发明申请
    CATALYTIC ELECTRODE WITH GRADIENT POROSITY AND CATALYST DENSITY FOR FUEL CELLS 有权
    具有梯度孔隙度和催化剂密度的燃料电池的催化电极

    公开(公告)号:US20110008705A1

    公开(公告)日:2011-01-13

    申请号:US12839124

    申请日:2010-07-19

    IPC分类号: H01M8/10

    摘要: A membrane electrode assembly (MEA) for a fuel cell comprising a gradient catalyst structure and a method of making the same. The gradient catalyst structure can include a plurality of catalyst nanoparticles, e.g., platinum, disposed on layered buckypaper. The layered buckypaper can include at least a first layer and a second layer and the first layer can have a lower porosity compared to the second layer. The gradient catalyst structure can include single-wall nanotubes, carbon nanofibers, or both in the first layer of the layered buckypaper and can include carbon nanofibers in the second layer of the layered buckypaper. The MEA can have a catalyst utilization efficiency of at least 0.35 gcat/kW or less.

    摘要翻译: 一种用于燃料电池的膜电极组件(MEA),其包括梯度催化剂结构及其制备方法。 梯度催化剂结构可以包括设置在分层压滤纸上的多个催化剂纳米颗粒,例如铂。 所述分层消音器可以包括至少第一层和第二层,并且与第二层相比,第一层可以具有较低的孔隙率。 梯度催化剂结构可以包括单层纳米管,碳纳米纤维或层状降压纸的第一层中的两者,并且可以在层叠的消泡剂的第二层中包括碳纳米纤维。 MEA的催化剂利用效率至少为0.35gcat / kW以下。