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公开(公告)号：US20150057356A1
公开(公告)日：2015-02-26
申请号：US14389838
申请日：2013-04-08
Applicant: DOW GLOBAL TECHNOLOGIES LLC
Inventor： Nicholas S. Grasman , True L. Rogers , Oliver Petermann , Meinolf Brackhagen , Roland Adden
IPC: A61K47/38 , B29C47/00 , A61K9/20 , A61K31/192
CPC classification number: A61K47/38 , A61K9/1652 , A61K9/2095 , A61K31/192 , B29C47/004 , B29C47/0066 , B29C2793/009 , B29K2001/08 , B29K2105/0035 , C08B11/193 , C08L1/28 , C08L1/284
Abstract: A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.
Abstract translation: 一种熔融挤出的聚合物组合物，其包含a）至少一种纤维素醚，b）一种或多种活性成分和c）一种或多种任选的添加剂，其中所述至少一种纤维素醚具有0.05至0.55的MS（羟烷基）和羟基 脱水葡萄糖单元的基团被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.32以下，其中s23是脱水葡萄糖单元的摩尔分数，其中只有2位和3位的两个羟基， 脱水葡萄糖单元的位置被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位上的两个羟基仅被甲基取代。
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公开(公告)号：US20220056157A1
公开(公告)日：2022-02-24
申请号：US17394458
申请日：2021-08-05
Applicant: DOW GLOBAL TECHNOLOGIES LLC
Inventor： Oliver Petermann , Matthias Knarr , Meinolf Brackhagen , Matthias Sprehe
Abstract: A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, comprises the steps of a) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid, b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, and c) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.
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公开(公告)号：US11142633B2
公开(公告)日：2021-10-12
申请号：US15764498
申请日：2016-09-29
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Matthias Knarr , Meinolf Brackhagen
IPC: C08L1/32 , A23L33/10 , A61K9/48 , A61K47/38 , A23P10/30 , B29C41/14 , C08B13/00 , C08B1/00 , B29K1/00 , B29L31/00
Abstract: An aqueous composition which is useful for producing coatings and capsule shells comprises a) dispersed particles of an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent hydrocarbon group and A is hydrogen or a cation, and the total degree of ester substitution is more than 0.70, and b) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, II) the total degree of ester substitution is from 0.03 to 0.70, and III) the esterified cellulose ether b) has a solubility in water of at least 2.0 weight percent at 2° C.
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公开(公告)号：US20210102004A1
公开(公告)日：2021-04-08
申请号：US16072744
申请日：2017-10-17
Applicant: Dow Global Technologies LLC
Inventor： Meinolf Brackhagen , Oliver Petermann , Rene Kelling
IPC: C08B13/00
Abstract: An esterified cellulose ether is produced in a highly efficient manner in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride, wherein the process comprises the steps of a) preparing a reaction mixture comprising the cellulose ether, the aliphatic monocarboxylic acid anhydride and the aliphatic carboxylic acid such that the molar ratio of aliphatic carboxylic acid to anhydroglucose units of cellulose ether is up to 9.0:1 and heating the reaction mixture to a temperature of from 60° C. to 110° C. prior to, during or after mixing the components of the reaction mixture, and b) keeping the reaction mixture at least 15 minutes at the temperature of from 60° C. to 110° C. before adding dicarboxylic acid anhydride to the reaction mixture.
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公开(公告)号：US10947322B2
公开(公告)日：2021-03-16
申请号：US16072650
申请日：2017-06-20
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann
Abstract: An esterified cellulose ether is provided wherein the ester groups are phthalyl groups, the degree of substitution of phthalyl groups is from 0.02 to 0.18, the degree of neutralization of phthalyl groups is not more than 0.75, and the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2° C.
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Patent Agency Ranking
公开(公告)号：US10730957B2
公开(公告)日：2020-08-04
申请号：US14420911
申请日：2013-08-15
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Matthias Sprehe , Warren K. Miller
Abstract: In a process for preparing an esterified cellulose ether a cellulose ether is esterified with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an alkali metal carboxylate and an aliphatic carboxylic acid, wherein the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is not more than [1.20/1] and the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is from [3.55/1] to [9.0/1].
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公开(公告)号：US20190119451A1
公开(公告)日：2019-04-25
申请号：US16072673
申请日：2017-05-01
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Jin Zhao
Abstract: An aqueous composition comprising a cellulose ether acetate being at least partially dissolved in an aqueous liquid is produced in a process, wherein an aqueous liquid is mixed with a cellulose ether acetate having a degree of substitution of acetyl groups, DSAc, of from 0.05 to 0.75 and the temperature of the mixture of the cellulose ether acetate and the aqueous liquid is set to less than 10 C to at least partially dissolve the cellulose ether acetate in the aqueous liquid.
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公开(公告)号：US10214594B2
公开(公告)日：2019-02-26
申请号：US15550097
申请日：2016-03-08
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Matthias Knarr , Robert B. Appell
IPC: A61K9/48 , A61K47/38 , C08B11/20 , C08B13/00 , A23L33/125
Abstract: An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C.
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公开(公告)号：US20180319898A1
公开(公告)日：2018-11-08
申请号：US16038327
申请日：2018-07-18
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Meinolf Brackhagen , Matthias Sprehe , Robert B. Appell
CPC classification number: C08B13/00 , A61K9/2866 , A61K9/4816 , A61K47/38
Abstract: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up 19 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. and which have a weight average molecular weight Mw of at least 90,000 Dalton, are useful for preparing solid dispersions comprising drugs.
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公开(公告)号：US20180105607A1
公开(公告)日：2018-04-19
申请号：US15569197
申请日：2016-05-10
Applicant: Dow Global Technologies LLC
Inventor： Oliver Petermann , Meinolf Brackhagen
Abstract: An esterified cellulose ether of increased weight average molecular weight is produced in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride, wherein the process comprises the steps of a) preparing a reaction mixture comprising the cellulose ether, the dicarboxylic acid anhydride and a reaction diluent and heating the reaction mixture to a temperature of from 60 C to 110 C prior to, during or after mixing the components of the reaction mixture, and b) adding continuously or in at least three portions the monocarboxylic acid anhydride to the reaction mixture of step a) and completing the reaction.
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