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    Closed Loop Cardiac Resynchronization Therapy Using Cardiac Activation Sequence Information
    41.
    发明申请
    Closed Loop Cardiac Resynchronization Therapy Using Cardiac Activation Sequence Information 有权
    闭环心脏再同步治疗使用心脏激活序列信息

    公开(公告)号：US20090076557A1

    公开(公告)日：2009-03-19

    申请号：US12276070

    申请日：2008-11-21

    申请人： Yi Zhang ,  Yinghong Yu ,  Aaron R. McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Scott A. Meyer

    发明人： Yi Zhang ,  Yinghong Yu ,  Aaron R. McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Scott A. Meyer

    IPC分类号： A61N1/39 ,  A61N1/368

    CPC分类号： A61N1/3712 ,  A61N1/3627 ,  A61N1/365 ,  G06F19/00

    摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.

    摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。 设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。 使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。 在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

    User interface system for use with multipolar pacing leads
    42.
    发明授权
    User interface system for use with multipolar pacing leads 有权
    用于多极起搏线的用户界面系统

    公开(公告)号：US09138585B2

    公开(公告)日：2015-09-22

    申请号：US13198499

    申请日：2011-08-04

    申请人： Sunipa Saha ,  Kenneth N. Hayes ,  Keith L. Herrmann ,  James Kalgren ,  Aaron R. McCabe ,  Holly Rockweiler ,  Shibaji Shome ,  Krzysztof Z. Siejko

    发明人： Sunipa Saha ,  Kenneth N. Hayes ,  Keith L. Herrmann ,  James Kalgren ,  Aaron R. McCabe ,  Holly Rockweiler ,  Shibaji Shome ,  Krzysztof Z. Siejko

    IPC分类号： A61N1/372 ,  A61N1/368 ,  A61N1/36

    CPC分类号： A61N1/37247 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/3686 ,  A61N1/37241

    摘要： An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device.

    摘要翻译： 可以提供电刺激电极或载体的交互式表示，例如用于配置电刺激电极的组合。 在一个示例中，电极或测试参数可以图形化或在表中呈现。 用户界面可以被配置为接收用户输入的指定电极组合或用于测试或用于编程可植入或动态医疗设备的矢量。 该界面可用于响应于电极的第一选择来指示所建议的电极组合或载体。 可以对电极组合和载体进行测试，并且可以使用交互式表示向使用者呈现测试结果。 在一个示例中，测试结果可以由处理器分析，并且可选地用于编程可植入或动态医疗设备。

    Self-diagnostic method and system for implantable cardiac device
    44.
    发明授权
    Self-diagnostic method and system for implantable cardiac device 有权
    可植入心脏装置的自我诊断方法和系统

    公开(公告)号：US08712524B2

    公开(公告)日：2014-04-29

    申请号：US12829887

    申请日：2010-07-02

    申请人： Aaron R. McCabe ,  David J. Yonce

    发明人： Aaron R. McCabe ,  David J. Yonce

    IPC分类号： A61N1/00 ,  A61B5/04

    CPC分类号： A61N1/3706 ,  A61N1/0504 ,  A61N1/3756

    摘要： A self-diagnostic system for an implantable cardiac device such as a pacemaker, cardioverter, or resynchronization device which utilizes a subcutaneous ECG channel is described. The subcutaneous ECG channel allows the device to, in real time and independent of the standard pacing and sensing circuitry, verify the presence of pacing spikes, chamber senses, and other device outputs and hence establish and verify device integrity.

    摘要翻译： 描述了一种用于可植入心脏装置的自我诊断系统，例如采用皮下ECG通道的起搏器，心律转复器或再同步装置。 皮下ECG通道允许器件实时且独立于标准起搏和感测电路，验证起搏尖峰，腔室感测和其他器件输出的存在，从而建立和验证器件的完整性。

    Method and apparatus for pacing safety margin
    45.
    发明授权
    Method and apparatus for pacing safety margin 有权
    起搏安全幅度的方法和装置

    公开(公告)号：US08565879B2

    公开(公告)日：2013-10-22

    申请号：US13071680

    申请日：2011-03-25

    申请人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

    发明人： Amy Jean Brisben ,  Shibaji Shome ,  Kenneth N. Hayes ,  Yanting Dong ,  Aaron R. McCabe ,  Scott A. Meyer ,  Kevin John Stalsberg

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36585 ,  A61N1/3712

    摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.

    摘要翻译： 一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。 控制器电路包括安全裕度计算电路。 控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。 安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。

    Arrhythmia Discrimination using ECG's Sensed from Multiple Implanted Electrodes
    48.
    发明申请
    Arrhythmia Discrimination using ECG's Sensed from Multiple Implanted Electrodes 有权
    使用从多个植入电极感应的ECG的心律失常鉴别

    公开(公告)号：US20110137192A1

    公开(公告)日：2011-06-09

    申请号：US13027608

    申请日：2011-02-15

    申请人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

    发明人： Yi Zhang ,  Carlos Alberto Ricci ,  Jeffrey E. Stahmann ,  Aaron R. McCabe ,  Scott A. Meyer ,  Yinghong Yu

    IPC分类号： A61B5/0402

    CPC分类号： A61B5/04011 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。