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公开(公告)号：US20120035685A1
公开(公告)日：2012-02-09
申请号：US13198499
申请日：2011-08-04
申请人： Sunipa Saha , Kenneth N. Hayes , Keith L. Herrmann , James Kalgren , Aaron R. McCabe , Holly Rockweiler , Shibaji Shome , Krzysztof Z. Siejko
发明人： Sunipa Saha , Kenneth N. Hayes , Keith L. Herrmann , James Kalgren , Aaron R. McCabe , Holly Rockweiler , Shibaji Shome , Krzysztof Z. Siejko
CPC分类号： A61N1/37247 , A61N1/056 , A61N1/36185 , A61N1/3686 , A61N1/37241
摘要： An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device.
摘要翻译： 可以提供电刺激电极或载体的交互式表示，例如用于配置电刺激电极的组合。 在一个示例中，电极或测试参数可以图形化或在表中呈现。 用户界面可以被配置为接收用户输入的指定电极组合或矢量，用于测试或用于编程可植入或动态医疗设备。 该界面可用于响应于电极的第一选择来指示建议的电极组合或载体。 可以对电极组合和载体进行测试，并且可以使用交互式表示向使用者呈现测试结果。 在一个示例中，测试结果可以由处理器分析，并且可选地用于编程可植入或动态医疗设备。
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公开(公告)号：US09138585B2
公开(公告)日：2015-09-22
申请号：US13198499
申请日：2011-08-04
申请人： Sunipa Saha , Kenneth N. Hayes , Keith L. Herrmann , James Kalgren , Aaron R. McCabe , Holly Rockweiler , Shibaji Shome , Krzysztof Z. Siejko
发明人： Sunipa Saha , Kenneth N. Hayes , Keith L. Herrmann , James Kalgren , Aaron R. McCabe , Holly Rockweiler , Shibaji Shome , Krzysztof Z. Siejko
CPC分类号： A61N1/37247 , A61N1/056 , A61N1/36185 , A61N1/3686 , A61N1/37241
摘要： An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device.
摘要翻译： 可以提供电刺激电极或载体的交互式表示，例如用于配置电刺激电极的组合。 在一个示例中，电极或测试参数可以图形化或在表中呈现。 用户界面可以被配置为接收用户输入的指定电极组合或用于测试或用于编程可植入或动态医疗设备的矢量。 该界面可用于响应于电极的第一选择来指示所建议的电极组合或载体。 可以对电极组合和载体进行测试，并且可以使用交互式表示向使用者呈现测试结果。 在一个示例中，测试结果可以由处理器分析，并且可选地用于编程可植入或动态医疗设备。
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公开(公告)号：US09061158B2
公开(公告)日：2015-06-23
申请号：US13301162
申请日：2011-11-21
CPC分类号： A61N1/3712 , A61N1/056 , A61N1/3702
摘要： Cardiac anodal electrostimulation detection systems and methods are described, such as for distinguishing between cathodal-only capture and at least partially anodal capture (e.g., combined anodal and cathodal capture, or between two anodes of which only one captures nearby cardiac tissue, etc.).
摘要翻译： 描述了心脏阳极电刺激检测系统和方法，例如用于区分仅阴极捕获和至少部分阳极捕获（例如，组合的阳极和阴极捕获，或在仅一个捕获附近的心脏组织的两个阳极之间） 。
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公开(公告)号：US20120130442A1
公开(公告)日：2012-05-24
申请号：US13301162
申请日：2011-11-21
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61N1/056 , A61N1/3702
摘要： Cardiac anodal electrostimulation detection systems and methods are described, such as for distinguishing between cathodal-only capture and at least partially anodal capture (e.g., combined anodal and cathodal capture, or between two anodes of which only one captures nearby cardiac tissue, etc.).
摘要翻译： 描述了心脏阳极电刺激检测系统和方法，例如用于区分仅阴极捕获和至少部分阳极捕获（例如，组合的阳极和阴极捕获，或在仅一个捕获附近的心脏组织的两个阳极之间） 。
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公开(公告)号：US08565879B2
公开(公告)日：2013-10-22
申请号：US13071680
申请日：2011-03-25
申请人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
发明人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/08
CPC分类号： A61N1/36585 , A61N1/3712
摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.
摘要翻译： 一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。 控制器电路包括安全裕度计算电路。 控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。 安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。
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公开(公告)号：US08880160B2
公开(公告)日：2014-11-04
申请号：US13552996
申请日：2012-07-19
申请人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
发明人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
CPC分类号： A61B5/0456 , A61B5/04012 , A61N1/3684 , A61N1/3686 , A61N1/3702 , A61N1/37247 , A61N1/3918
摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.
摘要翻译： 一种系统包括心脏信号感测和处理电路。 心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。 处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。 处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。
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公开(公告)号：US20110245890A1
公开(公告)日：2011-10-06
申请号：US13071680
申请日：2011-03-25
申请人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
发明人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
CPC分类号： A61N1/36585 , A61N1/3712
摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.
摘要翻译： 一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。 控制器电路包括安全裕度计算电路。 控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。 安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。
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公开(公告)号：US20130190636A1
公开(公告)日：2013-07-25
申请号：US13552996
申请日：2012-07-19
申请人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
发明人： Shibaji Shome , Pramodsingh Hirasingh Thakur , Yinghong Yu , Keith L. Herrmann , Aaron R. McCabe , Jiang Ding
IPC分类号： A61B5/0456 , A61B5/04
CPC分类号： A61B5/0456 , A61B5/04012 , A61N1/3684 , A61N1/3686 , A61N1/3702 , A61N1/37247 , A61N1/3918
摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.
摘要翻译： 一种系统包括心脏信号感测和处理电路。 心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。 处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。 处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。
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公开(公告)号：US20110004264A1
公开(公告)日：2011-01-06
申请号：US12822487
申请日：2010-06-24
申请人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
发明人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
IPC分类号： A61N1/08
CPC分类号： A61N1/3704 , A61N1/056 , A61N1/36185 , A61N1/36514 , A61N1/36542 , A61N1/36585 , A61N1/368 , A61N1/3686 , A61N1/371
摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.
摘要翻译： 描述了评估潜在的左心室（LV）起搏向量的方法。 执行早期消除测试以确定LV阴极的可行性。 基于早期消除测试，一些LV阴极被进一步测试消除。 确定为阴极的LV阴极被进一步测试。 测试可行的LV阴极电极的血液动力学效能。 然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。 潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。
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公开(公告)号：US08886313B2
公开(公告)日：2014-11-11
申请号：US12822487
申请日：2010-06-24
申请人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
发明人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
CPC分类号： A61N1/3704 , A61N1/056 , A61N1/36185 , A61N1/36514 , A61N1/36542 , A61N1/36585 , A61N1/368 , A61N1/3686 , A61N1/371
摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.
摘要翻译： 描述了评估潜在的左心室（LV）起搏向量的方法。 执行早期消除测试以确定LV阴极的可行性。 基于早期消除测试，一些LV阴极被进一步测试消除。 确定为阴极的LV阴极被进一步测试。 测试可行的LV阴极电极的血液动力学效能。 然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。 潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。
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