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    Assessment of pulmonary vascular resistance via pulmonary artery pressure
    2.
    发明授权
    Assessment of pulmonary vascular resistance via pulmonary artery pressure 有权
    通过肺动脉压力评估肺血管阻力

    公开(公告)号：US08632470B2

    公开(公告)日：2014-01-21

    申请号：US12566432

    申请日：2009-09-24

    申请人： Jeffrey E. Stahmann ,  Krzysztof Z. Siejko

    发明人： Jeffrey E. Stahmann ,  Krzysztof Z. Siejko

    IPC分类号： A61B5/02

    CPC分类号： A61B5/0215 ,  A61B5/02007

    摘要： Methods and systems for assessing pulmonary or systemic vascular resistance in a patient using pressure measurements are disclosed. An illustrative method of measuring pulmonary vascular resistance includes electrically inducing a retrograde pressure pulse within the heart, sensing at least one arterial pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a pulmonary artery, and computing a value of the pulmonary vascular resistance using the at least one sensed arterial pressure parameter. Data from multiple pulmonary vascular resistance assessments can be taken over an extended period of time within the patient to aid in detecting an underlying cardiac or pulmonary condition such as cardiogenic pulmonary edema.

    摘要翻译： 公开了使用压力测量来评估患者肺或全身血管阻力的方法和系统。 测量肺血管阻力的示例性方法包括电诱导心脏内的逆行压力脉冲，使用位于肺动脉内的压力传感器响应于逆行压力脉冲感测至少一个动脉压参数，以及计算肺动脉压 使用所述至少一个感测到的动脉压参数的血管阻力。 来自多个肺血管阻力评估的数据可以在患者内延长的时间段内进行，以帮助检测潜在的心脏或肺部疾病如心源性肺水肿。

    METHOD AND APPARATUS FOR THIRD HEART SOUND DETECTION
    4.
    发明申请
    METHOD AND APPARATUS FOR THIRD HEART SOUND DETECTION 有权
    用于第三次心脏检测的方法和装置

    公开(公告)号：US20130085407A1

    公开(公告)日：2013-04-04

    申请号：US13685170

    申请日：2012-11-26

    申请人： Krzysztof Z. Siejko ,  Gerrard M. Carlson

    发明人： Krzysztof Z. Siejko ,  Gerrard M. Carlson

    IPC分类号： A61B7/04

    CPC分类号： A61B7/04

    摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.

    摘要翻译： 心律管理系统包括提供检测第三心音的心音检测器（S3）。 诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。 心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。 然后从S3检测窗口内的声信号检测S3的出现。

    System and method for detection of HF decompensation based on signs and symptoms
    5.
    发明授权
    System and method for detection of HF decompensation based on signs and symptoms 有权
    基于体征和症状检测HF失代偿的系统和方法

    公开(公告)号：US08319648B2

    公开(公告)日：2012-11-27

    申请号：US12563882

    申请日：2009-09-21

    申请人： Krzysztof Z. Siejko ,  Viktoria A. Averina ,  Abhilash Patangay

    发明人： Krzysztof Z. Siejko ,  Viktoria A. Averina ,  Abhilash Patangay

    IPC分类号： G08B23/00

    CPC分类号： A61B5/0205 ,  A61B5/0002 ,  A61B5/7264 ,  G06F19/00

    摘要： In an example, physiologic information about a patient can be obtained and mapped to a first set of fuzzy logic membership functions, and a symptom status can be derived from the mapping of the physiologic information using a first fuzzy logic inference. In an example, the symptom status can be mapped to a second set of fuzzy logic membership functions, and a disease status can be derived from the mapping of the symptom status to the second set of fuzzy logic membership functions using a second fuzzy logic inference.

    摘要翻译： 在一个示例中，可以获得关于患者的生理信息并将其映射到第一组模糊逻辑隶属函数，并且可以使用第一模糊逻辑推断从生理信息的映射导出症状状态。 在一个示例中，症状状态可被映射到第二组模糊逻辑隶属函数，并且可以使用第二模糊逻辑推理从症状状态与第二组模糊逻辑隶属函数的映射导出疾病状态。

    THIRD HEART SOUND ACTIVITY INDEX FOR HEART FAILURE MONITORING
    6.
    发明申请
    THIRD HEART SOUND ACTIVITY INDEX FOR HEART FAILURE MONITORING 有权
    心脏失败监测的第三心音活动指标

    公开(公告)号：US20120271186A1

    公开(公告)日：2012-10-25

    申请号：US13540092

    申请日：2012-07-02

    申请人： Krzysztof Z. Siejko ,  Laura Green ,  Gerrard M. Carlson

    发明人： Krzysztof Z. Siejko ,  Laura Green ,  Gerrard M. Carlson

    IPC分类号： A61B7/00

    CPC分类号： A61B7/006 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02438 ,  A61B5/4836 ,  A61B5/6847 ,  A61B5/7275 ,  A61B7/04 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61N1/36514 ,  A61N1/37 ,  A61N1/3987

    摘要： A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart heats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including S3. An S3 detector detects occurrences of S3 from the acoustic signal. A heart sound processing system trends the S3 index on a periodic basis to allow continuous monitoring of the S3 activity level, which is indicative of conditions related to heart failure.

    摘要翻译： 心律管理系统提供第三心音（S3）指数的趋势。 S3指数是S3搏动次数与所有心脏热量的比率或比率的估计值，其中S3跳动各自是检测到S3的发生的心跳。 诸如加速度计或麦克风的可植入传感器感测到包括S3的指示心音的声信号。 S3检测器从声信号检测出S3的发生。 心脏声音处理系统周期性地推动S3指数，以允许连续监测S3活动水平，这表明与心力衰竭有关的病症。

    METHOD AND APPARATUS FOR DETECTING ATRIAL FILLING PRESSURE
    7.
    发明申请
    METHOD AND APPARATUS FOR DETECTING ATRIAL FILLING PRESSURE 有权
    用于检测心律灌注压的方法和装置

    公开(公告)号：US20120041317A1

    公开(公告)日：2012-02-16

    申请号：US13282143

    申请日：2011-10-26

    申请人： Abhilash Patangay ,  Krzysztof Z. Siejko

    发明人： Abhilash Patangay ,  Krzysztof Z. Siejko

    IPC分类号： A61B5/0205 ,  A61B5/0215 ,  A61B5/02

    CPC分类号： A61B5/02028 ,  A61B7/00 ,  A61N1/36514 ,  A61N1/36528

    摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.

    摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化

    CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION
    8.
    发明申请
    CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 有权
    心脏功能监测器使用信号指示铅运动

    公开(公告)号：US20110319778A1

    公开(公告)日：2011-12-29

    申请号：US13168531

    申请日：2011-06-24

    申请人： Robert J. Sweeney ,  Allan C. Shuros ,  Krzysztof Z. Siejko ,  David C. Olson ,  Frank Ingle

    发明人： Robert J. Sweeney ,  Allan C. Shuros ,  Krzysztof Z. Siejko ,  David C. Olson ,  Frank Ingle

    IPC分类号： A61B5/0245 ,  A61N1/365

    CPC分类号： A61N1/36514 ,  A61B5/02133 ,  A61B5/026 ,  A61N1/08 ,  A61N1/36142 ,  A61N1/36578

    摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.

    摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息来构建模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。

    DUAL-USE SENSOR FOR RATE RESPONSIVE PACING AND HEART SOUND MONITORING
    9.
    发明申请
    DUAL-USE SENSOR FOR RATE RESPONSIVE PACING AND HEART SOUND MONITORING 审中-公开
    用于速率响应的双用途传感器和心脏监听

    公开(公告)号：US20110077707A1

    公开(公告)日：2011-03-31

    申请号：US12955065

    申请日：2010-11-29

    申请人： Keith R. Maile ,  Krzysztof Z. Siejko

    发明人： Keith R. Maile ,  Krzysztof Z. Siejko

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36542 ,  A61N1/36585

    摘要： An implantable medical device includes a dual-use sensor such as a single accelerometer that senses an acceleration signal. A sensor processing circuit processes the acceleration signal to produce an activity level signal and a heart sound signal. The implantable medical device provides for rate responsive pacing in which at least one pacing parameter, such as the pacing interval, is dynamically adjusted based on the physical activity level. The implantable medical device also uses the heart sounds for pacing control purposes or transmits a heart sound signal to an external system for pacing control and/or diagnostic purposes.

    摘要翻译： 可植入医疗装置包括感测加速度信号的诸如单个加速度计的双重用途传感器。 传感器处理电路处理加速度信号以产生活动度信号和心音信号。 可植入医疗装置提供速率响应起搏，其中基于身体活动水平动态地调整至少一个起搏参数，例如起搏间隔。 可植入医疗装置还使用心脏声音用于起搏控制目的，或者将心音信号发送到外部系统用于起搏控制和/或诊断目的。