公开(公告)号：US08324290B2

公开(公告)日：2012-12-04

申请号：US12492483

申请日：2009-06-26

申请人： Shrojalkumar Desai ,  Marlene C. Schwarz ,  Mark Boden ,  Mohan Krishnan ,  Michael C. Smith ,  Frederick H. Strickler ,  Daniel J. Cooke

发明人： Shrojalkumar Desai ,  Marlene C. Schwarz ,  Mark Boden ,  Mohan Krishnan ,  Michael C. Smith ,  Frederick H. Strickler ,  Daniel J. Cooke

IPC分类号： A61N1/05

CPC分类号： C08G18/6204 ,  A61L27/18 ,  A61L31/06 ,  C08G18/10 ,  C08G18/12 ,  C08G18/4063 ,  C08G18/4854 ,  C08G18/4858 ,  C08G18/6511 ,  C08G18/7657 ,  C08L75/00 ,  C08G18/3206

摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.

摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

公开(公告)号：US08249720B2

公开(公告)日：2012-08-21

申请号：US12265282

申请日：2008-11-05

申请人： Kevin E. Verzal ,  Adam J. Rivard ,  Mohan Krishnan ,  G. Shantanu Reddy ,  Patsy A. Coppola ,  Edward L. Dickinson ,  Andrew C. Harvey

发明人： Kevin E. Verzal ,  Adam J. Rivard ,  Mohan Krishnan ,  G. Shantanu Reddy ,  Patsy A. Coppola ,  Edward L. Dickinson ,  Andrew C. Harvey

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N2001/0582

摘要： An implantable medical system includes a medical lead including an insulating sheath and a conductor and an anchoring device. The anchoring device defines an inner lumen adapted to coaxially receive the medical lead, where the inner lumen has an effective diameter. The anchoring device includes a sleeve including a substantially elongate body defining an outer surface and an inner bore. The anchoring device also has a compression member including a first end, a second end, and an intermediate portion between the first and second ends. The compression member is at least partially embedded in the sleeve such that compression of the first and second ends of the compression member toward one another causes the effective diameter of at least a portion of the inner lumen of the anchoring device to reversibly increase.

摘要翻译： 可植入医疗系统包括包括绝缘护套和导体的医疗引线和锚定装置。 锚定装置限定适于同轴地接纳医疗引线的内腔，其中内腔具有有效直径。 锚固装置包括套筒，其包括限定外表面和内孔的基本上细长的主体。 锚定装置还具有包括第一端部，第二端部和第一端部和第二端部之间的中间部分的压缩构件。 压缩构件至少部分地嵌入在套筒中，使得压缩构件的第一和第二端部彼此朝向彼此的压缩导致锚定装置的内腔的至少一部分的有效直径可逆地增加。

公开(公告)号：US20110030872A1

公开(公告)日：2011-02-10

申请号：US12903702

申请日：2010-10-13

申请人： Christopher P. Knapp ,  Kyle Hoecke ,  Mohan Krishnan ,  Rebecca Aron

发明人： Christopher P. Knapp ,  Kyle Hoecke ,  Mohan Krishnan ,  Rebecca Aron

IPC分类号： H01B13/08

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： This document discusses, among other things, a lead assembly including a lead body, at least one conductor extending through the lead body, and a covering having varied material properties. In an example, the covering is made by forming pieces of material having varied material properties. In another example, the covering is made by varying parameters such as heat or tension during wrapping of a piece of material onto a lead assembly.

摘要翻译： 该文件尤其涉及一种引线组件，其包括引线本体，延伸穿过引线主体的至少一个导体以及具有不同材料特性的覆盖物。 在一个实例中，覆盖物通过形成具有不同材料性质的材料制成。 在另一个示例中，通过在将一块材料包裹到引线组件上时，通过改变诸如热或张力的参数来进行覆盖。

公开(公告)号：US07835802B2

公开(公告)日：2010-11-16

申请号：US12046407

申请日：2008-03-11

申请人： Christopher P. Knapp ,  Kyle Hoecke ,  Mohan Krishnan ,  Rebecca Aron

发明人： Christopher P. Knapp ,  Kyle Hoecke ,  Mohan Krishnan ,  Rebecca Aron

IPC分类号： A61N1/02

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： This document discusses, among other things, a lead assembly including a lead body, at least one conductor extending through the lead body, and a covering having varied material properties. In an example, the covering is made by forming pieces of material having varied material properties. In another example, the covering is made by varying parameters such as heat or tension during wrapping of a piece of material onto a lead assembly.

摘要翻译： 该文件尤其涉及一种引线组件，其包括引线本体，延伸穿过引线主体的至少一个导体以及具有不同材料特性的覆盖物。 在一个实例中，覆盖物通过形成具有不同材料性质的材料制成。 在另一个示例中，通过在将一块材料包裹到引线组件上时，通过改变诸如热或张力的参数来进行覆盖。

公开(公告)号：US20100241209A1

公开(公告)日：2010-09-23

申请号：US12794186

申请日：2010-06-04

申请人： Mohan Krishnan

发明人： Mohan Krishnan

IPC分类号： A61N1/05

CPC分类号： A61N1/0563

摘要： An implantable lead includes a distal portion carrying a tissue stimulating electrode, at least a portion of its outer surface being adapted to stimulate cardiac tissue, wherein the electrode is covered by a pliable, electrically conductive sheath. The sheath is made of an electrically conductive material that does not rely on porosity for electrical charge transfer. The sheath is constructed and arranged to minimize or eliminate tissue ingrowth while passing sufficient electrical energy to stimulate the tissue.

摘要翻译： 可植入引线包括携带组织刺激电极的远端部分，其外表面的至少一部分适于刺激心脏组织，其中电极被柔韧的导电护套覆盖。 护套由导电材料制成，不依赖孔隙度进行电荷转移。 鞘被构造和布置成最小化或消除组织向内生长，同时通过足够的电能来刺激组织。

公开(公告)号：US20100042175A1

公开(公告)日：2010-02-18

申请号：US12539832

申请日：2009-08-12

申请人： Lili Liu ,  Mohan Krishnan ,  Bruce A. Tockman ,  David R. Wulfman

发明人： Lili Liu ,  Mohan Krishnan ,  Bruce A. Tockman ,  David R. Wulfman

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/36564 ,  A61M25/0041 ,  A61M2025/0002 ,  A61M2205/3344 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36585 ,  A61N2001/0585

摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.

摘要翻译： 心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。 铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。 引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。 压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。 脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

公开(公告)号：US20080046059A1

公开(公告)日：2008-02-21

申请号：US11462479

申请日：2006-08-04

申请人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand ,  Donna Osterkamp ,  Daniel J. Cooke

发明人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand ,  Donna Osterkamp ,  Daniel J. Cooke

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N1/057

摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. In one example, the lead body may comprise a heat-formed bias portion. In another example, an outer insulator is fused to the lead body. In such an example, a lead body fusable plug may be disposed distal to at least one conductor. In another example, the lead comprises an inner boot and an outer boot fused to one another. In another example, the lead includes an atraumatic tip fused to the lead distal end portion. In another example, the lead body is reducable in size using heat shrink tubing. In yet another example, two or more lead sections may be interconnected using an outer insulator fused to the respective lead bodies. In a further example, a stiffener member is fused to the lead body adjacent a lead component.

摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 在一个示例中，引线体可以包括加热成形的偏压部分。 在另一示例中，外绝缘体熔合到引线体。 在这种示例中，引线本体可熔插塞可以设置在至少一个导体的远侧。 在另一个示例中，引线包括彼此融合的内靴和外靴。 在另一示例中，引线包括熔合到引线远端部分的无创尖端。 在另一个例子中，使用热缩管可以使引线体尺寸减小。 在又一示例中，两个或更多个引线部分可以使用融合到相应引线体的外绝缘体互连。 在另一个例子中，加强件与引线部件相邻地被引导体熔合。

公开(公告)号：US20070184197A1

公开(公告)日：2007-08-09

申请号：US11734476

申请日：2007-04-12

申请人： Rebecca Aron ,  Jeffrey Bodner ,  Mohan Krishnan

发明人： Rebecca Aron ,  Jeffrey Bodner ,  Mohan Krishnan

IPC分类号： B05D3/00

CPC分类号： A61N1/056 ,  A61B5/042 ,  A61B2562/125

摘要： An implantable cardiac lead, and/or subassembly includes an elongate sheath of insulative material including an insulative first layer and a protective second layer. The insulative first layer has at least one activated surface to which the protective second layer is coupled.

摘要翻译： 可植入心脏引线和/或子组件包括绝缘材料的细长护套，包括绝缘第一层和保护性第二层。 绝缘第一层具有至少一个活化表面，保护性第二层被耦合到其上。

公开(公告)号：US20060015164A1

公开(公告)日：2006-01-19

申请号：US11031971

申请日：2005-01-07

申请人： Scott Partridge ,  Jeffrey Bartig ,  Bruce KenKnight ,  Peter Kelley ,  Mohan Krishnan

发明人： Scott Partridge ,  Jeffrey Bartig ,  Bruce KenKnight ,  Peter Kelley ,  Mohan Krishnan

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0573 ,  A61N2001/0585

摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.

公开(公告)号：US20060009829A1

公开(公告)日：2006-01-12

申请号：US10889504

申请日：2004-07-12

申请人： Rebecca Aron ,  Jeffrey Bodner ,  Mohan Krishnan

发明人： Rebecca Aron ,  Jeffrey Bodner ,  Mohan Krishnan

IPC分类号： A61B5/04

CPC分类号： A61N1/056 ,  A61B5/042 ,  A61B2562/125

摘要： An implantable cardiac lead, and/or subassembly includes an elongate sheath of insulative material including an insulative first layer and a protective second layer. The insulative first layer has at least one adhesive enhancing activated surface.

摘要翻译： 可植入心脏引线和/或子组件包括绝缘材料的细长护套，包括绝缘第一层和保护性第二层。 绝缘第一层具有至少一种增强粘合剂的活化表面。