公开(公告)号：US20220211496A1

公开(公告)日：2022-07-07

申请号：US17705131

申请日：2022-03-25

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.

公开(公告)号：US20220079749A1

公开(公告)日：2022-03-17

申请号：US17456532

申请日：2021-11-24

Applicant: Edwards Lifesciences Corporation

Inventor： Darshin S. Patel ,  Hannah Reed Bettencourt ,  Evan T. Schwartz ,  Sean Chow ,  Jocelyn Chau ,  Tri D. Tran ,  Alyssa Joy Gross ,  Yuanlong Du ,  Jason Seng-Che Lam ,  Alexander H. Cooper ,  Tram Ngoc Nguyen ,  Ngoc Huong Thi Nguyen ,  Kurt Kelly Reed ,  Corey Maurice Marshall

IPC: A61F2/24

Abstract: Systems, assemblies, and methods for treating valve regurgitation and other valve problems are described. Prosthetic valves can have integrated coverings or flanges. Prosthetic valves can have a flange attached to the inflow end of the annular frame and designed to extend outwardly therefrom. Docking devices can be used to repair or reshape native heart valves and to secure prosthetic heart valves at a specific location and position relative to a native heart valve. Delivery systems can be used to deploy a docking device into the heart, including a lubricous sleeve in the delivery system. Packaging and storage systems suitable for the delivery systems are described.

公开(公告)号：US20210001090A1

公开(公告)日：2021-01-07

申请号：US17026644

申请日：2020-09-21

Applicant: Edwards Lifesciences Corporation

Inventor： Tri D. Tran ,  Sean Chow ,  Ronaldo C. Cayabyab

IPC: A61M25/01 ,  A61F2/24 ,  A61M25/00

Abstract: In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion and a distal portion, and first and second pull wires having respective proximal portions and respective distal portions. The proximal portions of the first and second pull wires extend through the proximal portion of the shaft in close proximity to each other. The distal portions of the first and second pull wires extend through the distal portion of the shaft in close proximity to each other over a first distance defining a primary flexing section, diverge away from each other over a second distance, and then extend parallel to each other at angularly spaced locations over a third distance defining a secondary flexing section.

公开(公告)号：US20200368018A1

公开(公告)日：2020-11-26

申请号：US16992332

申请日：2020-08-13

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.

公开(公告)号：US20190192296A1

公开(公告)日：2019-06-27

申请号：US16252890

申请日：2019-01-21

Applicant: Edwards Lifesciences Corporation

Inventor： Evan T. Schwartz ,  Sean Chow ,  Sandip Vasant Pawar ,  Darshin S. Patel ,  Chambory Chhe ,  Arpit Laddha ,  Ngoc Huong Thi Nguyen ,  Waina Michelle Chu ,  Yuanlong Du ,  Michael Bukin ,  Boaz Manash ,  Sara Haivatov ,  Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/2442 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0091 ,  A61F2250/006

Abstract: A prosthetic heart valve includes a frame having an inflow end and an outflow end, and defining a longitudinal axis. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame. The covering includes a first woven portion extending circumferentially around the frame and including a plurality of texturized strands or yarns extending along the longitudinal axis of the frame. The covering further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. The texturized strands extend along the longitudinal axis of the frame from the first woven portion to the second woven portion and form a floating portion between the first woven portion and the second woven portion.

公开(公告)号：US10278819B2

公开(公告)日：2019-05-07

申请号：US15167760

申请日：2016-05-27

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

公开(公告)号：US20140324160A1

公开(公告)日：2014-10-30

申请号：US14326062

申请日：2014-07-08

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2250/0059

Abstract: Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.

Abstract translation: 公开的置换心脏瓣膜可被设计成在被输送到输送导管上时被递送到天然瓣膜部位。 通过例如将框架或支架结构与小叶结构沿着轴向分离，可以使替换阀的卷曲轮廓最小化。 公开的更换阀可以从压接轮廓可以最小化的输送配置转换到操作配置。 替换阀可以在输送和操作配置中完全组装。 在一些实施例中，小叶可以在输送构型中定位在支架的外部，并且在操作构型中定位在支架内腔的内部。 公开的替换阀可以包括将传单联接到支架的柔性套管，并且有助于过渡到操作构型。 还公开了植入所述替换阀的方法。