摘要:
The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要:
The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要:
The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要:
A piston arrangement includes a piston which is pin-ointed to a sliding block. The sliding block is molded directly onto the piston by injection molding so that no separate process step is required. The piston itself is part of the injection mold, an extremely precise fit can be guaranteed in the hinging area of the sliding block to the piston, which fit permits a reliable connection even when the piston surface is located in the connecting area outside the given tolerance, because by directly molding the sliding blocks onto the piston the tolerances are compensated.
摘要:
What is disclosed is a non-return valve comprising a sealing piston which is biased against a valve seat in the basic position inside a valve housing, and which is manufactured by a plastics injection molding technique.
摘要:
A positioning system is provided for use in a wind tunnel that results in accurate and dynamic orientation for a model while reducing aerodynamic interference. The system includes a pitch-yaw sleeve having a generally cylindrical shape and a torque tube disposed askew within the sleeve and rotatable about its longitudinal axis to drive a shaft. The shaft is generally elongated and crooked. The sting, to which a model is affixed, is rotatably attached to a distal end of the shaft. Rotation of the pitch-yaw tube and/or the pitch-yaw sleeve provides precise pitch and yaw orientation of the model, and rotation of the sting relative to the shaft provides precise roll orientation.
摘要:
A spectral characterization method accurately characterizes an applied signal spectrum that has multiple, spectrally-separated signal peaks. The method detects signal peaks within the spectrum and measures the spectral content of that spectrum using a first measurement bandwidth that is sufficiently wide to encompass each of the signal peaks and accurately measure a signal component of the spectrum. Spectral content of the spectrum measured using a narrow measurement bandwidth that accurately characterizes a noise component of the spectrum. Signal-to-noise ratio for the signal peaks can be calculated based on the measurements performed using the first and second measurement bandwidths. The spectral characterization method is implemented using a spectral measurement instrument having an adjustable measurement bandwidth.
摘要:
A gripping and locking arrangement for an aircraft movable component such as a flap door or undercarriage comprises a piston and a piston rod operative as a means for sensing a closing movement of the flap door or undercarriage, and also operative automatically actively to pull same by means of a closing hook into a position in which it is to be locked. The arrangement includes a locking member displaceable within the piston to move lock elements into a locking position and to hold them in the locking position until the arrangement receives a hydraulic pressure signal for causing lowering of the flap door or undercarriage, and the locking member is then displaced whereby the lock elements move into a release position. The hydraulic oil pressure can then act on the piston to produce displacement thereof into a position in which the closing hook releases the flap door or undercarriage component.