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公开(公告)号：US08530505B2
公开(公告)日：2013-09-10
申请号：US13360107
申请日：2012-01-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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42.发明授权Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof 有权取代的4-芳基-1,4-二氢-1,6-萘啶酰胺及其用途公开(公告)号：US08436180B2
公开(公告)日：2013-05-07
申请号：US12526951
申请日：2008-02-19
申请人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
发明人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。
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43.发明授权Aminoacyl prodrug derivatives and medicaments for treatment of thromboembolic disorders 有权氨基酰基前药衍生物和治疗血栓栓塞障碍的药物公开(公告)号：US08362015B2
公开(公告)日：2013-01-29
申请号：US12438097
申请日：2007-08-23
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20130005701A1
公开(公告)日：2013-01-03
申请号：US13360107
申请日：2012-01-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/422 , A61K31/5377 , C07D417/14 , A61K31/541 , C07D495/04 , C12N5/078 , A61K31/428 , A61K31/496 , A61K31/444 , A61K31/454 , A61K31/538 , A61K31/5383 , C07D413/14 , A61K31/4365
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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45.发明授权公开(公告)号：US08129378B2
公开(公告)日：2012-03-06
申请号：US12494879
申请日：2009-06-30
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/5377 , A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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46.发明授权Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权嘧啶酮衍生物作为抗急性和慢性炎性，缺血和重塑过程的治疗剂公开(公告)号：US07687510B2
公开(公告)日：2010-03-30
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： C07D239/22 , C07D401/04 , A61K31/5377
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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公开(公告)号：US20100048548A1
公开(公告)日：2010-02-25
申请号：US11919020
申请日：2006-04-08
IPC分类号： A61K31/422 , C12N5/00 , A61K31/5377 , A61K31/506 , A61K31/445 , A61K31/44 , C07D413/14 , C07D413/10 , A61P7/00 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to novel iminooxazolidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本发明涉及新的亚氨基恶唑烷，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞障碍的药物的用途。
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48.发明申请I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE 失效I-PHENY 1-3,4-二羟基嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US20100022537A1
公开(公告)日：2010-01-28
申请号：US12509936
申请日：2009-07-27
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , C07D239/02 , A61K31/505 , C07D413/02 , A61P29/00 , A61P9/00
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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49.发明授权公开(公告)号：US07576111B2
公开(公告)日：2009-08-18
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US20080090815A1
公开(公告)日：2008-04-17
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/541 , A61K31/421 , A61K31/4453 , A61P9/10 , C07D401/14 , C07D417/14 , C07D413/14 , C07D263/02 , A61P9/00 , A61K31/5355
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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